TY  - JOUR
AU  - Tesić, Vesna
AU  - Perović, Milka
AU  - Lazić, Divna
AU  - Kojić, Snežana
AU  - Smiljanić, Kosara
AU  - Ruzdijić, Sabera
AU  - Rakić, Ljubisav
AU  - Kanazir, Selma
PY  - 2015
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/880
AB  - Diminished glucocorticoid signaling is associated with an age-related decline in hippocampal functioning. In this study we demonstrate the effect of intermittent, every other day (EOD) feeding on the glucocorticoid hormone/glucocorticoid receptor (GR) system in the hippocampus of middle-aged (18-month-old) and aged (24-month-old) Wistar rats. In aged ad libitum-fed rats, a decrease in the level of total GR and GR phosphorylated at Ser(232) (pGR) was detected. Conversely, aged rats subjected to EOD feeding, starting from 6 months of age, showed an increase in GR and pGR levels and a higher content of hippocampal corticosterone. Furthermore, prominent nuclear staining of pGR was observed in CM pyramidal and DG granule neurons of aged EOD-fed rats. These changes were accompanied by increased Sglc-1 and decreased GFAP transcription, pointing to upregulated transcriptional activity of GR. EOD feeding also induced an increase in the expression of the mineralocorticoid receptor. Our results reveal that intermittent feeding restores impaired GR signaling in the hippocampus of aged animals by inducing rather than by stabilizing GR signaling during aging.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Steroid Biochemistry and Molecular Biology
T1  - Long-term intermittent feeding restores impaired GR signaling in the hippocampus of aged rat
EP  - 52
SP  - 43
VL  - 149
DO  - 10.1016/j.jsbmb.2015.01.013
ER  - 

@article{
author = "Tesić, Vesna and Perović, Milka and Lazić, Divna and Kojić, Snežana and Smiljanić, Kosara and Ruzdijić, Sabera and Rakić, Ljubisav and Kanazir, Selma",
year = "2015",
abstract = "Diminished glucocorticoid signaling is associated with an age-related decline in hippocampal functioning. In this study we demonstrate the effect of intermittent, every other day (EOD) feeding on the glucocorticoid hormone/glucocorticoid receptor (GR) system in the hippocampus of middle-aged (18-month-old) and aged (24-month-old) Wistar rats. In aged ad libitum-fed rats, a decrease in the level of total GR and GR phosphorylated at Ser(232) (pGR) was detected. Conversely, aged rats subjected to EOD feeding, starting from 6 months of age, showed an increase in GR and pGR levels and a higher content of hippocampal corticosterone. Furthermore, prominent nuclear staining of pGR was observed in CM pyramidal and DG granule neurons of aged EOD-fed rats. These changes were accompanied by increased Sglc-1 and decreased GFAP transcription, pointing to upregulated transcriptional activity of GR. EOD feeding also induced an increase in the expression of the mineralocorticoid receptor. Our results reveal that intermittent feeding restores impaired GR signaling in the hippocampus of aged animals by inducing rather than by stabilizing GR signaling during aging.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
title = "Long-term intermittent feeding restores impaired GR signaling in the hippocampus of aged rat",
pages = "52-43",
volume = "149",
doi = "10.1016/j.jsbmb.2015.01.013"
}

Tesić, V., Perović, M., Lazić, D., Kojić, S., Smiljanić, K., Ruzdijić, S., Rakić, L.,& Kanazir, S.. (2015). Long-term intermittent feeding restores impaired GR signaling in the hippocampus of aged rat. in Journal of Steroid Biochemistry and Molecular Biology
Pergamon-Elsevier Science Ltd, Oxford., 149, 43-52.
https://doi.org/10.1016/j.jsbmb.2015.01.013

Tesić V, Perović M, Lazić D, Kojić S, Smiljanić K, Ruzdijić S, Rakić L, Kanazir S. Long-term intermittent feeding restores impaired GR signaling in the hippocampus of aged rat. in Journal of Steroid Biochemistry and Molecular Biology. 2015;149:43-52.
doi:10.1016/j.jsbmb.2015.01.013 .

Tesić, Vesna, Perović, Milka, Lazić, Divna, Kojić, Snežana, Smiljanić, Kosara, Ruzdijić, Sabera, Rakić, Ljubisav, Kanazir, Selma, "Long-term intermittent feeding restores impaired GR signaling in the hippocampus of aged rat" in Journal of Steroid Biochemistry and Molecular Biology, 149 (2015):43-52,
https://doi.org/10.1016/j.jsbmb.2015.01.013 . .