TY  - JOUR
AU  - Đorđević, Valentina
AU  - Stanković, Marija
AU  - Branković-Srecković, Vesna
AU  - Rakićević, Ljiljana
AU  - Damnjanović, Tatjana
AU  - Antonijević, Nebojša
AU  - Radojković, Dragica
PY  - 2012
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/596
AB  - The role of thrombophilia in the pathogenesis of stroke is still controversial, especially in the pediatric stroke. In order to examine the role of common thrombophilic mutations in children and adults with stroke, a case-control study was carried out in a group of 80 children and 73 younger adult patients. The control groups encompassed 100 healthy children and 120 healthy blood donors. Our results showed no significant differences in the frequency of factor V (FV) Leiden, FII G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T variants between patient groups and corresponding controls. According to our results, carriers of 677CT genotype have 3.62 higher risks to develop stroke in children than in adults (P  lt  .001). The obtained data indicate that heterozygosity for MTHFR C677T variant represents a possible important risk factor for pediatric stroke and suggest a different role of this gene variant in etiology of stroke in pediatric and adult patients.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Clinical and Applied Thrombosis-Hemostasis
T1  - Prothrombotic Genetic Risk Factors in Stroke: A Possible Different Role in Pediatric and Adult Patients
EP  - 661
IS  - 6
SP  - 658
VL  - 18
DO  - 10.1177/1076029611432136
ER  - 

@article{
author = "Đorđević, Valentina and Stanković, Marija and Branković-Srecković, Vesna and Rakićević, Ljiljana and Damnjanović, Tatjana and Antonijević, Nebojša and Radojković, Dragica",
year = "2012",
abstract = "The role of thrombophilia in the pathogenesis of stroke is still controversial, especially in the pediatric stroke. In order to examine the role of common thrombophilic mutations in children and adults with stroke, a case-control study was carried out in a group of 80 children and 73 younger adult patients. The control groups encompassed 100 healthy children and 120 healthy blood donors. Our results showed no significant differences in the frequency of factor V (FV) Leiden, FII G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T variants between patient groups and corresponding controls. According to our results, carriers of 677CT genotype have 3.62 higher risks to develop stroke in children than in adults (P  lt  .001). The obtained data indicate that heterozygosity for MTHFR C677T variant represents a possible important risk factor for pediatric stroke and suggest a different role of this gene variant in etiology of stroke in pediatric and adult patients.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Clinical and Applied Thrombosis-Hemostasis",
title = "Prothrombotic Genetic Risk Factors in Stroke: A Possible Different Role in Pediatric and Adult Patients",
pages = "661-658",
number = "6",
volume = "18",
doi = "10.1177/1076029611432136"
}

Đorđević, V., Stanković, M., Branković-Srecković, V., Rakićević, L., Damnjanović, T., Antonijević, N.,& Radojković, D.. (2012). Prothrombotic Genetic Risk Factors in Stroke: A Possible Different Role in Pediatric and Adult Patients. in Clinical and Applied Thrombosis-Hemostasis
Sage Publications Inc, Thousand Oaks., 18(6), 658-661.
https://doi.org/10.1177/1076029611432136

Đorđević V, Stanković M, Branković-Srecković V, Rakićević L, Damnjanović T, Antonijević N, Radojković D. Prothrombotic Genetic Risk Factors in Stroke: A Possible Different Role in Pediatric and Adult Patients. in Clinical and Applied Thrombosis-Hemostasis. 2012;18(6):658-661.
doi:10.1177/1076029611432136 .

Đorđević, Valentina, Stanković, Marija, Branković-Srecković, Vesna, Rakićević, Ljiljana, Damnjanović, Tatjana, Antonijević, Nebojša, Radojković, Dragica, "Prothrombotic Genetic Risk Factors in Stroke: A Possible Different Role in Pediatric and Adult Patients" in Clinical and Applied Thrombosis-Hemostasis, 18, no. 6 (2012):658-661,
https://doi.org/10.1177/1076029611432136 . .