Müller, Jonas I.

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Synthesis, Stereochemical Determination, and Antimicrobial Evaluation of Myxocoumarin A

Hertrampf, Gesa; Vojnović, Sandra; Müller, Jonas I.; Merten, Christian; Nikodinović-Runić, Jasmina; Gulder, Tobias A. M.

(2023) 

TY  - JOUR
AU  - Hertrampf, Gesa
AU  - Vojnović, Sandra
AU  - Müller, Jonas I.
AU  - Merten, Christian
AU  - Nikodinović-Runić, Jasmina
AU  - Gulder, Tobias A. M.
PY  - 2023
UR  - https://doi.org/10.1021/acs.joc.3c01285
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2153
AB  - The myxobacterial natural product myxocoumarin A from Stigmatella aurantiaca MYX-030 has remarkable antifungal activity against agriculturally relevant pathogens. To broaden the initial evaluation of its biological potential, we herein completed the first total synthesis of myxocoumarin A. This synthetic access facilitated stereochemical investigations on the natural product structure, revealing its (R)-configuration. Biological activity profiling showed a lack of activity against Candida spp. and Gram-negative bacteria but revealed strong antibiotic activities against Bacillus subtilis and Staphylococcus aureus, including MRSA.
T2  - The Journal of Organic Chemistry
T1  - Synthesis, Stereochemical Determination, and Antimicrobial Evaluation of Myxocoumarin A
EP  - 14188
IS  - 19
SP  - 14184
VL  - 88
DO  - 10.1021/acs.joc.3c01285
ER  - 
@article{
author = "Hertrampf, Gesa and Vojnović, Sandra and Müller, Jonas I. and Merten, Christian and Nikodinović-Runić, Jasmina and Gulder, Tobias A. M.",
year = "2023",
abstract = "The myxobacterial natural product myxocoumarin A from Stigmatella aurantiaca MYX-030 has remarkable antifungal activity against agriculturally relevant pathogens. To broaden the initial evaluation of its biological potential, we herein completed the first total synthesis of myxocoumarin A. This synthetic access facilitated stereochemical investigations on the natural product structure, revealing its (R)-configuration. Biological activity profiling showed a lack of activity against Candida spp. and Gram-negative bacteria but revealed strong antibiotic activities against Bacillus subtilis and Staphylococcus aureus, including MRSA.",
journal = "The Journal of Organic Chemistry",
title = "Synthesis, Stereochemical Determination, and Antimicrobial Evaluation of Myxocoumarin A",
pages = "14188-14184",
number = "19",
volume = "88",
doi = "10.1021/acs.joc.3c01285"
}
Hertrampf, G., Vojnović, S., Müller, J. I., Merten, C., Nikodinović-Runić, J.,& Gulder, T. A. M.. (2023). Synthesis, Stereochemical Determination, and Antimicrobial Evaluation of Myxocoumarin A. in The Journal of Organic Chemistry, 88(19), 14184-14188.
https://doi.org/10.1021/acs.joc.3c01285
Hertrampf G, Vojnović S, Müller JI, Merten C, Nikodinović-Runić J, Gulder TAM. Synthesis, Stereochemical Determination, and Antimicrobial Evaluation of Myxocoumarin A. in The Journal of Organic Chemistry. 2023;88(19):14184-14188.
doi:10.1021/acs.joc.3c01285 .
Hertrampf, Gesa, Vojnović, Sandra, Müller, Jonas I., Merten, Christian, Nikodinović-Runić, Jasmina, Gulder, Tobias A. M., "Synthesis, Stereochemical Determination, and Antimicrobial Evaluation of Myxocoumarin A" in The Journal of Organic Chemistry, 88, no. 19 (2023):14184-14188,
https://doi.org/10.1021/acs.joc.3c01285 . .
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