TY  - JOUR
AU  - Babić, Mirjana
AU  - Veljović, Katarina
AU  - Popović, Nikola
AU  - Golić, Nataša
AU  - Radojković, Dragica
AU  - Stanković, Marija
PY  - 2023
UR  - https://doi.org/10.1093/jambio/lxad257
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2204
AB  - Chronic lung diseases are a major and increasing global health problem, commonly caused by cigarette smoke. We aimed to explore the antioxidant effects of lactic acid bacteria (LAB) against cigarette smoke in bronchial epithelial cells.The antioxidant effects of 21 heat-killed (HK) LAB strains were tested in cigarette smoke stimulated BEAS-2B cells and 3-D bronchospheres organoids. We showed that HK Lactiplantibacillus plantarum BGPKM22 possesses antioxidant activity against cigarette smoke, resistance to hydrogen peroxide, and free radical neutralizing activity. We demonstrated that HK BGPKM22 inhibited cigarette smoke induced expression of the Aryl hydrocarbon receptor (AhR) and Nuclear factor erythroid 2 related factor 2 (Nrf2) genes. The cell-free supernatant (SN) of BGPKM22 fully confirmed the effects of HK BGPKM22.For the first time, we revealed that HK and SN of L. plantarum BGPKM22 possess antioxidant activity and modulate AhR and Nrf2 gene expression in bronchial epithelial cells exposed to cigarette smoke.
T2  - Journal of Applied Microbiology
T1  - Antioxidant effect of lactic acid bacteria in human bronchial epithelial cells exposed to cigarette smoke
SP  - lxad257
VL  - n/a
DO  - 10.1093/jambio/lxad257
ER  - 

@article{
author = "Babić, Mirjana and Veljović, Katarina and Popović, Nikola and Golić, Nataša and Radojković, Dragica and Stanković, Marija",
year = "2023",
abstract = "Chronic lung diseases are a major and increasing global health problem, commonly caused by cigarette smoke. We aimed to explore the antioxidant effects of lactic acid bacteria (LAB) against cigarette smoke in bronchial epithelial cells.The antioxidant effects of 21 heat-killed (HK) LAB strains were tested in cigarette smoke stimulated BEAS-2B cells and 3-D bronchospheres organoids. We showed that HK Lactiplantibacillus plantarum BGPKM22 possesses antioxidant activity against cigarette smoke, resistance to hydrogen peroxide, and free radical neutralizing activity. We demonstrated that HK BGPKM22 inhibited cigarette smoke induced expression of the Aryl hydrocarbon receptor (AhR) and Nuclear factor erythroid 2 related factor 2 (Nrf2) genes. The cell-free supernatant (SN) of BGPKM22 fully confirmed the effects of HK BGPKM22.For the first time, we revealed that HK and SN of L. plantarum BGPKM22 possess antioxidant activity and modulate AhR and Nrf2 gene expression in bronchial epithelial cells exposed to cigarette smoke.",
journal = "Journal of Applied Microbiology",
title = "Antioxidant effect of lactic acid bacteria in human bronchial epithelial cells exposed to cigarette smoke",
pages = "lxad257",
volume = "n/a",
doi = "10.1093/jambio/lxad257"
}

Babić, M., Veljović, K., Popović, N., Golić, N., Radojković, D.,& Stanković, M.. (2023). Antioxidant effect of lactic acid bacteria in human bronchial epithelial cells exposed to cigarette smoke. in Journal of Applied Microbiology, n/a, lxad257.
https://doi.org/10.1093/jambio/lxad257

Babić M, Veljović K, Popović N, Golić N, Radojković D, Stanković M. Antioxidant effect of lactic acid bacteria in human bronchial epithelial cells exposed to cigarette smoke. in Journal of Applied Microbiology. 2023;n/a:lxad257.
doi:10.1093/jambio/lxad257 .

Babić, Mirjana, Veljović, Katarina, Popović, Nikola, Golić, Nataša, Radojković, Dragica, Stanković, Marija, "Antioxidant effect of lactic acid bacteria in human bronchial epithelial cells exposed to cigarette smoke" in Journal of Applied Microbiology, n/a (2023):lxad257,
https://doi.org/10.1093/jambio/lxad257 . .