TY  - JOUR
AU  - Joncić Savić, Katarina
AU  - Đokic, Lidija
AU  - Stanković, Nada
AU  - Morić, Ivana
AU  - Pavlović, Bojan
AU  - Šenerović, Lidija
AU  - Aydogan, Cem
AU  - Pavić, Aleksandar
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S1756464623002177
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1982
AB  - Candidiasis caused by Candida albicans is one of the most common fungal infections in modern society. The limited arsenal of clinical drugs, their side effects and emerging resistance, largely contribute to the low efficacy of current antifungal therapies. The morphogenetic yeast-to-hyphae transition is the key virulence feature for the establishment of local and systemic C. albicans infections. We show that a delfinidin-rich fruit extract from Aristotelia chilensis ([Molina], Stuntz) (maqui berry) inhibits filamentation of C. albicans, in both laboratory and clinical strains. The extract acts synergistically with nystatin, with filament formation completely prevented by the combination of ¼×MIC of nystatin and 0.125 mg/ml of the extract. The combination treatment results in increased survival of C. albicans-infected zebrafish embryos compared to treatment with nystatin. Neither the extract nor its combination with nystatin was toxic at effective doses. These results warrant further investigation of maqui berry extract as adjuvant antifungal treatment.
T2  - Journal of Functional Foods
T1  - Maqui berry extract inhibits filamentation of Candidaalbicans and improves the antifungal efficacy of nystatin
SP  - 105617
VL  - 106
DO  - 10.1016/j.jff.2023.105617
ER  - 

@article{
author = "Joncić Savić, Katarina and Đokic, Lidija and Stanković, Nada and Morić, Ivana and Pavlović, Bojan and Šenerović, Lidija and Aydogan, Cem and Pavić, Aleksandar",
year = "2023",
abstract = "Candidiasis caused by Candida albicans is one of the most common fungal infections in modern society. The limited arsenal of clinical drugs, their side effects and emerging resistance, largely contribute to the low efficacy of current antifungal therapies. The morphogenetic yeast-to-hyphae transition is the key virulence feature for the establishment of local and systemic C. albicans infections. We show that a delfinidin-rich fruit extract from Aristotelia chilensis ([Molina], Stuntz) (maqui berry) inhibits filamentation of C. albicans, in both laboratory and clinical strains. The extract acts synergistically with nystatin, with filament formation completely prevented by the combination of ¼×MIC of nystatin and 0.125 mg/ml of the extract. The combination treatment results in increased survival of C. albicans-infected zebrafish embryos compared to treatment with nystatin. Neither the extract nor its combination with nystatin was toxic at effective doses. These results warrant further investigation of maqui berry extract as adjuvant antifungal treatment.",
journal = "Journal of Functional Foods",
title = "Maqui berry extract inhibits filamentation of Candidaalbicans and improves the antifungal efficacy of nystatin",
pages = "105617",
volume = "106",
doi = "10.1016/j.jff.2023.105617"
}

Joncić Savić, K., Đokic, L., Stanković, N., Morić, I., Pavlović, B., Šenerović, L., Aydogan, C.,& Pavić, A.. (2023). Maqui berry extract inhibits filamentation of Candidaalbicans and improves the antifungal efficacy of nystatin. in Journal of Functional Foods, 106, 105617.
https://doi.org/10.1016/j.jff.2023.105617

Joncić Savić K, Đokic L, Stanković N, Morić I, Pavlović B, Šenerović L, Aydogan C, Pavić A. Maqui berry extract inhibits filamentation of Candidaalbicans and improves the antifungal efficacy of nystatin. in Journal of Functional Foods. 2023;106:105617.
doi:10.1016/j.jff.2023.105617 .

Joncić Savić, Katarina, Đokic, Lidija, Stanković, Nada, Morić, Ivana, Pavlović, Bojan, Šenerović, Lidija, Aydogan, Cem, Pavić, Aleksandar, "Maqui berry extract inhibits filamentation of Candidaalbicans and improves the antifungal efficacy of nystatin" in Journal of Functional Foods, 106 (2023):105617,
https://doi.org/10.1016/j.jff.2023.105617 . .