TY  - JOUR
AU  - Lukić, Jovanka
AU  - Jancić, I.
AU  - Mirković, N.
AU  - Bufan, B.
AU  - Đokić, Jelena
AU  - Milenković, M.
AU  - Begović, Jelena
AU  - Strahinić, Ivana
AU  - Lozo, Jelena
PY  - 2017
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1003
AB  - In the light of the increasing resistance of bacterial pathogens to antibiotics, one of the main global strategies in applied science is development of alternative treatments, which would be safe both for the host and from the environmental perspective. Accordingly, the aim of this study was to test whether two lactic acid bacteria (LAB) strains, Lactococcus lactis BGBU1-4 and Lactobacillus salivarius BGHO1, could be applied as safe supplements for Listeria infection. Two major research objectives were set: to compare the effects of BGBU1-4 and BGHO1 on early immune response in gut tissue of Wistar rats co-administered with Listeria monocytogenes ATCC19111 and next, to test how this applies to their usage as therapeutics in acute ATCC19111 infection. Intestinal villi (IV), Peyer's patches (PP) and mesenteric lymph nodes (MLN) were used for the analysis. The results showed that BGHO1 increased the mRNA expression of innate immune markers CD14, interleukin (IL)-1 beta and tumour necrosis factor (TNF)-alpha in PP and IV, and, in parallel, caused a decrease of listeriolysin O (LLO) mRNA expression in same tissues. In MLN of BGHO1 treated rats, LLO expression was increased, along with an increase of the expression of OX-62 mRNA and CD69, pointing to the activation of adaptive immunity. On the other hand, in BGBU1-4 treated rats, there was no reduction of LLO mRNA expression and no induction of innate immunity markers in intestinal tissue. Additionally, CD14 and IL-1 beta, as well as LLO, but not OX-62 mRNA and CD69 expression, were elevated in MLN of BGBU1-4 treated rats. However, when applied therapeutically, both, BGBU1-4 and BGHO1, lowered Listeria count in spleens of infected rats. Our results not only reveal the potential of LAB to ameliorate Listeria infections, but suggest different immunological effects of two different LAB strains, both of which could be effective in Listeria elimination.
PB  - Wageningen Academic Publishers, Wageningen
T2  - Beneficial Microbes
T1  - Lactococcus lactis and Lactobacillus salivarius differently modulate early immunological response of Wistar rats co-administered with Listeria monocytogenes
EP  - 822
IS  - 5
SP  - 809
VL  - 8
DO  - 10.3920/BM2017.0007
ER  - 

@article{
author = "Lukić, Jovanka and Jancić, I. and Mirković, N. and Bufan, B. and Đokić, Jelena and Milenković, M. and Begović, Jelena and Strahinić, Ivana and Lozo, Jelena",
year = "2017",
abstract = "In the light of the increasing resistance of bacterial pathogens to antibiotics, one of the main global strategies in applied science is development of alternative treatments, which would be safe both for the host and from the environmental perspective. Accordingly, the aim of this study was to test whether two lactic acid bacteria (LAB) strains, Lactococcus lactis BGBU1-4 and Lactobacillus salivarius BGHO1, could be applied as safe supplements for Listeria infection. Two major research objectives were set: to compare the effects of BGBU1-4 and BGHO1 on early immune response in gut tissue of Wistar rats co-administered with Listeria monocytogenes ATCC19111 and next, to test how this applies to their usage as therapeutics in acute ATCC19111 infection. Intestinal villi (IV), Peyer's patches (PP) and mesenteric lymph nodes (MLN) were used for the analysis. The results showed that BGHO1 increased the mRNA expression of innate immune markers CD14, interleukin (IL)-1 beta and tumour necrosis factor (TNF)-alpha in PP and IV, and, in parallel, caused a decrease of listeriolysin O (LLO) mRNA expression in same tissues. In MLN of BGHO1 treated rats, LLO expression was increased, along with an increase of the expression of OX-62 mRNA and CD69, pointing to the activation of adaptive immunity. On the other hand, in BGBU1-4 treated rats, there was no reduction of LLO mRNA expression and no induction of innate immunity markers in intestinal tissue. Additionally, CD14 and IL-1 beta, as well as LLO, but not OX-62 mRNA and CD69 expression, were elevated in MLN of BGBU1-4 treated rats. However, when applied therapeutically, both, BGBU1-4 and BGHO1, lowered Listeria count in spleens of infected rats. Our results not only reveal the potential of LAB to ameliorate Listeria infections, but suggest different immunological effects of two different LAB strains, both of which could be effective in Listeria elimination.",
publisher = "Wageningen Academic Publishers, Wageningen",
journal = "Beneficial Microbes",
title = "Lactococcus lactis and Lactobacillus salivarius differently modulate early immunological response of Wistar rats co-administered with Listeria monocytogenes",
pages = "822-809",
number = "5",
volume = "8",
doi = "10.3920/BM2017.0007"
}

Lukić, J., Jancić, I., Mirković, N., Bufan, B., Đokić, J., Milenković, M., Begović, J., Strahinić, I.,& Lozo, J.. (2017). Lactococcus lactis and Lactobacillus salivarius differently modulate early immunological response of Wistar rats co-administered with Listeria monocytogenes. in Beneficial Microbes
Wageningen Academic Publishers, Wageningen., 8(5), 809-822.
https://doi.org/10.3920/BM2017.0007

Lukić J, Jancić I, Mirković N, Bufan B, Đokić J, Milenković M, Begović J, Strahinić I, Lozo J. Lactococcus lactis and Lactobacillus salivarius differently modulate early immunological response of Wistar rats co-administered with Listeria monocytogenes. in Beneficial Microbes. 2017;8(5):809-822.
doi:10.3920/BM2017.0007 .

Lukić, Jovanka, Jancić, I., Mirković, N., Bufan, B., Đokić, Jelena, Milenković, M., Begović, Jelena, Strahinić, Ivana, Lozo, Jelena, "Lactococcus lactis and Lactobacillus salivarius differently modulate early immunological response of Wistar rats co-administered with Listeria monocytogenes" in Beneficial Microbes, 8, no. 5 (2017):809-822,
https://doi.org/10.3920/BM2017.0007 . .

TY  - CONF
AU  - Arsenović-Ranin, Nevena
AU  - Jancić, I.
AU  - Sefik-Bukilica, M.
AU  - Zivojinović, S.
AU  - Damjanov, N.
AU  - Spasovski, Vesna
AU  - Srzentić Dražilov, Sanja
AU  - Stanković, Biljana
AU  - Pavlović, Sonja
PY  - 2012
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/549
PB  - Wiley-Blackwell, Hoboken
C3  - Immunology
T1  - Polymorphism at position-174 of the interleukin-6 gene influences outcome of etanercept therapy in rheumatoid arthritis
EP  - 24
SP  - 24
VL  - 137
UR  - https://hdl.handle.net/21.15107/rcub_imagine_549
ER  - 

@conference{
author = "Arsenović-Ranin, Nevena and Jancić, I. and Sefik-Bukilica, M. and Zivojinović, S. and Damjanov, N. and Spasovski, Vesna and Srzentić Dražilov, Sanja and Stanković, Biljana and Pavlović, Sonja",
year = "2012",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Immunology",
title = "Polymorphism at position-174 of the interleukin-6 gene influences outcome of etanercept therapy in rheumatoid arthritis",
pages = "24-24",
volume = "137",
url = "https://hdl.handle.net/21.15107/rcub_imagine_549"
}

Arsenović-Ranin, N., Jancić, I., Sefik-Bukilica, M., Zivojinović, S., Damjanov, N., Spasovski, V., Srzentić Dražilov, S., Stanković, B.,& Pavlović, S.. (2012). Polymorphism at position-174 of the interleukin-6 gene influences outcome of etanercept therapy in rheumatoid arthritis. in Immunology
Wiley-Blackwell, Hoboken., 137, 24-24.
https://hdl.handle.net/21.15107/rcub_imagine_549

Arsenović-Ranin N, Jancić I, Sefik-Bukilica M, Zivojinović S, Damjanov N, Spasovski V, Srzentić Dražilov S, Stanković B, Pavlović S. Polymorphism at position-174 of the interleukin-6 gene influences outcome of etanercept therapy in rheumatoid arthritis. in Immunology. 2012;137:24-24.
https://hdl.handle.net/21.15107/rcub_imagine_549 .

Arsenović-Ranin, Nevena, Jancić, I., Sefik-Bukilica, M., Zivojinović, S., Damjanov, N., Spasovski, Vesna, Srzentić Dražilov, Sanja, Stanković, Biljana, Pavlović, Sonja, "Polymorphism at position-174 of the interleukin-6 gene influences outcome of etanercept therapy in rheumatoid arthritis" in Immunology, 137 (2012):24-24,
https://hdl.handle.net/21.15107/rcub_imagine_549 .