TY  - JOUR
AU  - Pavić, Aleksandar
AU  - Mitić-Culafić, Dragana
AU  - Nebojša, Jasnic
AU  - Nikolić, Biljana
AU  - Simin, Nataša
AU  - Vasiljević, Branka
AU  - Knežević-Vukčević, Jelena
PY  - 2019
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1240
AB  - The objective of this study was to evaluate potential of two chemically characterized edible wild onion species, Allium flavum and Allium carinatum, to reduce side effects of cytostatic doxorubicin (Dox). Since Dox application is mainly limited due to its high cardiotoxicity, while there are no approved cardioprotective agents for the prevention of Dox adverse effects, new co-treatments are urgently needed. Here, we showed that methanol extracts expressed high antioxidant activity and synergistically increased Dox anticancer activity against human hepatoma (HepG2) and lung carcinoma (A549) cells, while protected normal human fibroblasts (MRC-5) from Dox cytotoxicity. Analysis of the antioxidative enzymes level (catalase and superoxide dismutases) showed that the catalase level was differently altered in cancer cells compared to normal cells upon applied treatments. In vivo toxicity evaluation in the zebrafish model revealed significantly lower toxicity of extracts compared to Dox, and no teratogenic effects at applied doses. We found that extracts successfully rescued the Dox-treated embryos of life-threating cardiomyopathy, while at the same time reduced developmental toxicity and neutropenia. Further analysis demonstrated that extracts had higher anti-angiogenic activity than sunitinib or auranofin, clinically used anti-angiogenic drugs. In addition, angiogenesis was markedly more suppressed in Dox-extract cotreatments than upon single treatments.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - Biomedicine & Pharmacotherapy
T1  - Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin
EP  - 2491
SP  - 2482
VL  - 109
DO  - 10.1016/j.biopha.2018.11.106
ER  - 

@article{
author = "Pavić, Aleksandar and Mitić-Culafić, Dragana and Nebojša, Jasnic and Nikolić, Biljana and Simin, Nataša and Vasiljević, Branka and Knežević-Vukčević, Jelena",
year = "2019",
abstract = "The objective of this study was to evaluate potential of two chemically characterized edible wild onion species, Allium flavum and Allium carinatum, to reduce side effects of cytostatic doxorubicin (Dox). Since Dox application is mainly limited due to its high cardiotoxicity, while there are no approved cardioprotective agents for the prevention of Dox adverse effects, new co-treatments are urgently needed. Here, we showed that methanol extracts expressed high antioxidant activity and synergistically increased Dox anticancer activity against human hepatoma (HepG2) and lung carcinoma (A549) cells, while protected normal human fibroblasts (MRC-5) from Dox cytotoxicity. Analysis of the antioxidative enzymes level (catalase and superoxide dismutases) showed that the catalase level was differently altered in cancer cells compared to normal cells upon applied treatments. In vivo toxicity evaluation in the zebrafish model revealed significantly lower toxicity of extracts compared to Dox, and no teratogenic effects at applied doses. We found that extracts successfully rescued the Dox-treated embryos of life-threating cardiomyopathy, while at the same time reduced developmental toxicity and neutropenia. Further analysis demonstrated that extracts had higher anti-angiogenic activity than sunitinib or auranofin, clinically used anti-angiogenic drugs. In addition, angiogenesis was markedly more suppressed in Dox-extract cotreatments than upon single treatments.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "Biomedicine & Pharmacotherapy",
title = "Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin",
pages = "2491-2482",
volume = "109",
doi = "10.1016/j.biopha.2018.11.106"
}

Pavić, A., Mitić-Culafić, D., Nebojša, J., Nikolić, B., Simin, N., Vasiljević, B.,& Knežević-Vukčević, J.. (2019). Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin. in Biomedicine & Pharmacotherapy
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 109, 2482-2491.
https://doi.org/10.1016/j.biopha.2018.11.106

Pavić A, Mitić-Culafić D, Nebojša J, Nikolić B, Simin N, Vasiljević B, Knežević-Vukčević J. Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin. in Biomedicine & Pharmacotherapy. 2019;109:2482-2491.
doi:10.1016/j.biopha.2018.11.106 .

Pavić, Aleksandar, Mitić-Culafić, Dragana, Nebojša, Jasnic, Nikolić, Biljana, Simin, Nataša, Vasiljević, Branka, Knežević-Vukčević, Jelena, "Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin" in Biomedicine & Pharmacotherapy, 109 (2019):2482-2491,
https://doi.org/10.1016/j.biopha.2018.11.106 . .