TY  - JOUR
AU  - Radović, J.
AU  - Maksimović-Ivanić, Danijela
AU  - Timotijević, Gordana
AU  - Popadić, S.
AU  - Ramić, Z.
AU  - Trajković, V.
AU  - Miljković, D.
AU  - Stošić-Grujičić, Stanislava
AU  - Mijatović, S.
PY  - 2012
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/550
AB  - Intrinsic characteristics of melanoma cells such as expression of inducible nitric oxide synthase (iNOS), redox status, and activity of signaling pathways involved in proliferation, differentiation and cell death define the response of the cells to the diverse treatments. In this context we compared the effectiveness of herbal antaquinone aloe emodin (AE) against mouse B16 melanoma and human A375, different in initial activity of ERK1/2, constitutive iNOS expression and basal level of reactive oxygen species (ROS). Both cell lines are sensitive to AE treatment. However, while the agent induces differentiation of B16 cells toward melanocytes, in A375 cells promoted massive apoptosis. Differentiation of B16 cells, characterized by enhanced melanin production and tyrosinase activity, was mediated by H2O2 production synchronized with rapid p53 accumulation and enhanced expression of cyclins D1 and D3. Caspase mediated apoptosis triggered in A375 cells was accompanied with Bcl-2 but not iNOS down-regulation. In addition, opposite regulation of Akt-ERK1/2 axis in AE treated B16 and A375 cells correlated with different outcome of the treatment. However, AE in a dose-dependent manner rescued both B16 and A375 cells from doxorubicin- or paclitaxel-induced killing. These data indicate that caution is warranted when AE is administrated to the patients with conventional chemotherapy.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Cell-type dependent response of melanoma cells to aloe emodin
EP  - 3189
IS  - 9
SP  - 3181
VL  - 50
DO  - 10.1016/j.fct.2012.05.047
ER  - 

@article{
author = "Radović, J. and Maksimović-Ivanić, Danijela and Timotijević, Gordana and Popadić, S. and Ramić, Z. and Trajković, V. and Miljković, D. and Stošić-Grujičić, Stanislava and Mijatović, S.",
year = "2012",
abstract = "Intrinsic characteristics of melanoma cells such as expression of inducible nitric oxide synthase (iNOS), redox status, and activity of signaling pathways involved in proliferation, differentiation and cell death define the response of the cells to the diverse treatments. In this context we compared the effectiveness of herbal antaquinone aloe emodin (AE) against mouse B16 melanoma and human A375, different in initial activity of ERK1/2, constitutive iNOS expression and basal level of reactive oxygen species (ROS). Both cell lines are sensitive to AE treatment. However, while the agent induces differentiation of B16 cells toward melanocytes, in A375 cells promoted massive apoptosis. Differentiation of B16 cells, characterized by enhanced melanin production and tyrosinase activity, was mediated by H2O2 production synchronized with rapid p53 accumulation and enhanced expression of cyclins D1 and D3. Caspase mediated apoptosis triggered in A375 cells was accompanied with Bcl-2 but not iNOS down-regulation. In addition, opposite regulation of Akt-ERK1/2 axis in AE treated B16 and A375 cells correlated with different outcome of the treatment. However, AE in a dose-dependent manner rescued both B16 and A375 cells from doxorubicin- or paclitaxel-induced killing. These data indicate that caution is warranted when AE is administrated to the patients with conventional chemotherapy.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Cell-type dependent response of melanoma cells to aloe emodin",
pages = "3189-3181",
number = "9",
volume = "50",
doi = "10.1016/j.fct.2012.05.047"
}

Radović, J., Maksimović-Ivanić, D., Timotijević, G., Popadić, S., Ramić, Z., Trajković, V., Miljković, D., Stošić-Grujičić, S.,& Mijatović, S.. (2012). Cell-type dependent response of melanoma cells to aloe emodin. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 50(9), 3181-3189.
https://doi.org/10.1016/j.fct.2012.05.047

Radović J, Maksimović-Ivanić D, Timotijević G, Popadić S, Ramić Z, Trajković V, Miljković D, Stošić-Grujičić S, Mijatović S. Cell-type dependent response of melanoma cells to aloe emodin. in Food and Chemical Toxicology. 2012;50(9):3181-3189.
doi:10.1016/j.fct.2012.05.047 .

Radović, J., Maksimović-Ivanić, Danijela, Timotijević, Gordana, Popadić, S., Ramić, Z., Trajković, V., Miljković, D., Stošić-Grujičić, Stanislava, Mijatović, S., "Cell-type dependent response of melanoma cells to aloe emodin" in Food and Chemical Toxicology, 50, no. 9 (2012):3181-3189,
https://doi.org/10.1016/j.fct.2012.05.047 . .

TY  - CONF
AU  - Mijatović, S.
AU  - Radović, J.
AU  - Timotijević, Gordana
AU  - Mojić, M.
AU  - Miljković, D.
AU  - Dekanski, D.
AU  - Stošić-Grujičić, Stanislava
PY  - 2009
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/349
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway
EP  - 903
IS  - 9
SP  - 903
VL  - 75
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1443
ER  - 

@conference{
author = "Mijatović, S. and Radović, J. and Timotijević, Gordana and Mojić, M. and Miljković, D. and Dekanski, D. and Stošić-Grujičić, Stanislava",
year = "2009",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway",
pages = "903-903",
number = "9",
volume = "75",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1443"
}

Mijatović, S., Radović, J., Timotijević, G., Mojić, M., Miljković, D., Dekanski, D.,& Stošić-Grujičić, S.. (2009). Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 75(9), 903-903.
https://hdl.handle.net/21.15107/rcub_ibiss_1443

Mijatović S, Radović J, Timotijević G, Mojić M, Miljković D, Dekanski D, Stošić-Grujičić S. Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway. in Planta Medica. 2009;75(9):903-903.
https://hdl.handle.net/21.15107/rcub_ibiss_1443 .

Mijatović, S., Radović, J., Timotijević, Gordana, Mojić, M., Miljković, D., Dekanski, D., Stošić-Grujičić, Stanislava, "Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway" in Planta Medica, 75, no. 9 (2009):903-903,
https://hdl.handle.net/21.15107/rcub_ibiss_1443 .