TY  - JOUR
AU  - Popović, Dušanka
AU  - Kulas, Jelena
AU  - Tucovic, Dina
AU  - Popov Aleksandrov, Aleksandra
AU  - Glamoclija, Jasmina
AU  - Sokovic Bajic, Svetlana
AU  - Tolinački, Maja
AU  - Golić, Nataša
AU  - Mirkov, Ivana
PY  - 2023
UR  - https://www.sciencedirect.com/science/article/pii/S1286457923000898
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2094
AB  - Since the realization that the lungs are not sterile but are normally inhabited by various bacterial species, studies have been conducted to define healthy lung microbiota and to investigate whether it changes during lung diseases, infections, and inflammation. Using next-generation sequencing, we investigated bacterial microbiota from whole lungs in two rat strains (previously shown to differ in gut microbiota composition) in a healthy state and during pulmonary infection caused by the opportunistic fungus Aspergillus fumigatus. No differences in alpha diversity indices and microbial composition between DA and AO rats before infection were noted. Fungal infection caused dysbiosis in both rat strains, characterized by increased alpha diversity indices and unchanged beta diversity. The relative abundance of genera and species was increased in DA but decreased in AO rats during infection. Changes in lung microbiota coincided with inflammation (in both rat strains) and oxidative stress (in DA rats). Disparate response of lung microbiota in DA and AO rats to pulmonary fungal infection might render these two rat strains differentially susceptible to a subsequent inflammatory insult.
T2  - Microbes and Infection
T2  - Microbes and InfectionMicrobes and Infection
T1  - Lung microbiota changes during pulmonary Aspergillus fumigatus infection in rats
SP  - 105186
DO  - 10.1016/j.micinf.2023.105186
ER  - 

@article{
author = "Popović, Dušanka and Kulas, Jelena and Tucovic, Dina and Popov Aleksandrov, Aleksandra and Glamoclija, Jasmina and Sokovic Bajic, Svetlana and Tolinački, Maja and Golić, Nataša and Mirkov, Ivana",
year = "2023",
abstract = "Since the realization that the lungs are not sterile but are normally inhabited by various bacterial species, studies have been conducted to define healthy lung microbiota and to investigate whether it changes during lung diseases, infections, and inflammation. Using next-generation sequencing, we investigated bacterial microbiota from whole lungs in two rat strains (previously shown to differ in gut microbiota composition) in a healthy state and during pulmonary infection caused by the opportunistic fungus Aspergillus fumigatus. No differences in alpha diversity indices and microbial composition between DA and AO rats before infection were noted. Fungal infection caused dysbiosis in both rat strains, characterized by increased alpha diversity indices and unchanged beta diversity. The relative abundance of genera and species was increased in DA but decreased in AO rats during infection. Changes in lung microbiota coincided with inflammation (in both rat strains) and oxidative stress (in DA rats). Disparate response of lung microbiota in DA and AO rats to pulmonary fungal infection might render these two rat strains differentially susceptible to a subsequent inflammatory insult.",
journal = "Microbes and Infection, Microbes and InfectionMicrobes and Infection",
title = "Lung microbiota changes during pulmonary Aspergillus fumigatus infection in rats",
pages = "105186",
doi = "10.1016/j.micinf.2023.105186"
}

Popović, D., Kulas, J., Tucovic, D., Popov Aleksandrov, A., Glamoclija, J., Sokovic Bajic, S., Tolinački, M., Golić, N.,& Mirkov, I.. (2023). Lung microbiota changes during pulmonary Aspergillus fumigatus infection in rats. in Microbes and Infection, 105186.
https://doi.org/10.1016/j.micinf.2023.105186

Popović D, Kulas J, Tucovic D, Popov Aleksandrov A, Glamoclija J, Sokovic Bajic S, Tolinački M, Golić N, Mirkov I. Lung microbiota changes during pulmonary Aspergillus fumigatus infection in rats. in Microbes and Infection. 2023;:105186.
doi:10.1016/j.micinf.2023.105186 .

Popović, Dušanka, Kulas, Jelena, Tucovic, Dina, Popov Aleksandrov, Aleksandra, Glamoclija, Jasmina, Sokovic Bajic, Svetlana, Tolinački, Maja, Golić, Nataša, Mirkov, Ivana, "Lung microbiota changes during pulmonary Aspergillus fumigatus infection in rats" in Microbes and Infection (2023):105186,
https://doi.org/10.1016/j.micinf.2023.105186 . .