@article{
author = "Milošević, Katarina and Rsovac, Snežana and Nestorović, Branimir and Nikolić, Aleksandra",
year = "2018",
abstract = "INTRODUCTION: Several studies have identified neuromuscular blocking agents as the most common cause of
anaphylaxis during general anesthesia. The reported data vary considerably between countries.
AIM: In this study we have investigated anaphylactic reactions to neuromuscular blocking agents, general
anaesthetics and latex in children from Serbia.
METHODS: This case series study has encompassed hypersensitivity testing in 78 children over a period of twelve
consecutive months. The diagnostic protocol consisted of a case history, immunoglobulin E (IgE) testing and skin
tests for hypersensitivity to neuromuscular blocking agents, general anesthetics and latex.
RESULTS: Of 78 children, 63% were hypersensitive to neuromuscular blocking agents, 28% to latex, 13% to
hypnotics, 10% to opioids and 15% to coloids. Sixty cases (77%) of anaphylaxis were IgE-mediated. Among
children who underwent more than one intervention, the presence of cross-sensibilisation for neuromuscular
blocking agents commercially available in Serbia was identified in 77% of cases.
CONCLUSION: Neuromuscular blocking agents were the most frequent causal agents of anaphylaxis in Serbian
children, as verified by skin tests and specific IgE tests. High frequencies of allergies to neuromuscular blocking
agents and latex obtained in this study underscore the importance of carrying out an allergy study to detect an
allergic cause in perioperative reactions, UVOD: Nekoliko studija je identifikovalo neuromuskularne blokatore kao najčešći uzrok anafilakse tokom opšte
anestezije, ali prijavljeni podaci znatno variraju između zemalja.
CILJ: U ovoj studiji ispitivane su anafilaktičke reakcije na neuromuskularne blokatore, opšte anestetike i lateks
kod dece iz Srbije.
METODE: Ova studija serije slučajeva obuhvatila je testiranje preosetljivosti kod 78 dece tokom perioda od
dvanaest uzastopnih meseci. Dijagnostički protokol se sastojao od istorije slučajeva, testiranja imunoglobulina E
(IgE) i kožnih testova za preosetljivost na neuromuskularne blokatore, opšte anestetike i lateks.
REZULTATI: Od 78 ispitivane dece, 63% je preosetljivo na neuromuskularne blokatore, 28% na lateks, 13% na
hipnotike, 10% na opioide i 15% na koloide. U 60 slučajeva (77%) anafilaksija je posredovana IgE-om. Među
decom koja su prošla više od jedne intervencije, prisustvo unakrsne senzibilizacije za neuromuskularne bokatore
komercijalno dostupne u Srbiji identifikovano je u 77% slučajeva.
ZAKLJUČAK: Neuromuskularni blokatori najčešći su uzročni agensi anafilaksije kod srpske dece, što je potvrđeno
testovima kože i specifičnim IgE testovima. Visoke učestalosti alergija na neuromuskularne blokatore i lateks
dobijene u ovoj studiji naglašavaju važnost sprovođenja studija alergije kako bi se otkrili alergijski uzroci u
perioperativnim reakcijama.",
publisher = "Novi Sad : Udruženje Medicina danas"",
journal = "Medicina danas",
title = "Serbian study of perioperative anaphylaxis in children, Perioperativna anafilaksa kod dece u Srbiji",
pages = "180-175",
number = "10-12",
volume = "17",
url = "https://hdl.handle.net/21.15107/rcub_imagine_2319"
}