TY  - JOUR
AU  - Marković, Zoran M.
AU  - Labudova, Martina
AU  - Danko, Martin
AU  - Matijašević, Danka
AU  - Micusik, Matej
AU  - Nadazdy, Vojtech
AU  - Kovacova, Maria
AU  - Kleinova, Angela
AU  - Spitalsky, Zdeno
AU  - Pavlović, Vladimir
AU  - Milivojević, Dusan D.
AU  - Medić, Mina
AU  - Marković, Biljana M. Todorovic
PY  - 2020
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1336
AB  - The addition of heteroatoms to pristine carbon quantum dots (CQDs) change their structure and optical properties. In this study, fluorine (F)- and chlorine (Cl)-doped CQDs are prepared by the one-step green hydrothermal route from sodium fluoride, sodium chloride, urea, and citric acid as the starting precursors. Microscopy analysis reveals that the average size of these quantum dots is 5 +/- 2 nm, whereas the chemical study shows the existence of C-F and C-Cl bonds. The produced F- and Cl-doped CQDs have fluorescence quantum yields of 0.151 and 0.284, respectively, at an excitation wavelength of 450 nm. Charge transfer resistance of F- and Cl-doped CQDs films is 2 orders of magnitude higher than in the pristine CQD films. Transport band gap of the doped CQDs is 2 eV bigger than that of pristine CQDs. Radical scavenging activity shows very good antioxidant activity of doped CQDs. Antibacterial testing reveals poor antibacterial activity against Staphylococcus aureus and Escherichia coli. The F- and Cl-doped CQDs are successfully used as fluorescent probes for cell imaging as shown by confocal microscopy.
PB  - Amer Chemical Soc, Washington
T2  - Acs Sustainable Chemistry & Engineering
T1  - Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging
EP  - 16338
IS  - 43
SP  - 16327
VL  - 8
DO  - 10.1021/acssuschemeng.0c06260
ER  - 

@article{
author = "Marković, Zoran M. and Labudova, Martina and Danko, Martin and Matijašević, Danka and Micusik, Matej and Nadazdy, Vojtech and Kovacova, Maria and Kleinova, Angela and Spitalsky, Zdeno and Pavlović, Vladimir and Milivojević, Dusan D. and Medić, Mina and Marković, Biljana M. Todorovic",
year = "2020",
abstract = "The addition of heteroatoms to pristine carbon quantum dots (CQDs) change their structure and optical properties. In this study, fluorine (F)- and chlorine (Cl)-doped CQDs are prepared by the one-step green hydrothermal route from sodium fluoride, sodium chloride, urea, and citric acid as the starting precursors. Microscopy analysis reveals that the average size of these quantum dots is 5 +/- 2 nm, whereas the chemical study shows the existence of C-F and C-Cl bonds. The produced F- and Cl-doped CQDs have fluorescence quantum yields of 0.151 and 0.284, respectively, at an excitation wavelength of 450 nm. Charge transfer resistance of F- and Cl-doped CQDs films is 2 orders of magnitude higher than in the pristine CQD films. Transport band gap of the doped CQDs is 2 eV bigger than that of pristine CQDs. Radical scavenging activity shows very good antioxidant activity of doped CQDs. Antibacterial testing reveals poor antibacterial activity against Staphylococcus aureus and Escherichia coli. The F- and Cl-doped CQDs are successfully used as fluorescent probes for cell imaging as shown by confocal microscopy.",
publisher = "Amer Chemical Soc, Washington",
journal = "Acs Sustainable Chemistry & Engineering",
title = "Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging",
pages = "16338-16327",
number = "43",
volume = "8",
doi = "10.1021/acssuschemeng.0c06260"
}

Marković, Z. M., Labudova, M., Danko, M., Matijašević, D., Micusik, M., Nadazdy, V., Kovacova, M., Kleinova, A., Spitalsky, Z., Pavlović, V., Milivojević, D. D., Medić, M.,& Marković, B. M. T.. (2020). Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging. in Acs Sustainable Chemistry & Engineering
Amer Chemical Soc, Washington., 8(43), 16327-16338.
https://doi.org/10.1021/acssuschemeng.0c06260

Marković ZM, Labudova M, Danko M, Matijašević D, Micusik M, Nadazdy V, Kovacova M, Kleinova A, Spitalsky Z, Pavlović V, Milivojević DD, Medić M, Marković BMT. Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging. in Acs Sustainable Chemistry & Engineering. 2020;8(43):16327-16338.
doi:10.1021/acssuschemeng.0c06260 .

Marković, Zoran M., Labudova, Martina, Danko, Martin, Matijašević, Danka, Micusik, Matej, Nadazdy, Vojtech, Kovacova, Maria, Kleinova, Angela, Spitalsky, Zdeno, Pavlović, Vladimir, Milivojević, Dusan D., Medić, Mina, Marković, Biljana M. Todorovic, "Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging" in Acs Sustainable Chemistry & Engineering, 8, no. 43 (2020):16327-16338,
https://doi.org/10.1021/acssuschemeng.0c06260 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Jovanović, Svetlana P.
AU  - Masković, Pavle Z.
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Danko, Martin
AU  - Micusik, Matej
AU  - Jovanović, Dragana J.
AU  - Kleinova, Angela
AU  - Spitalsky, Zdeno
AU  - Pavlović, Vladimir B.
AU  - Marković, Biljana M. Todorovic
PY  - 2019
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1221
AB  - Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Photochemistry and Photobiology B-Biology
T1  - Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines
VL  - 200
DO  - 10.1016/j.jphotobiol.2019.111647
ER  - 

@article{
author = "Marković, Zoran M. and Jovanović, Svetlana P. and Masković, Pavle Z. and Mojsin, Marija and Stevanović, Milena and Danko, Martin and Micusik, Matej and Jovanović, Dragana J. and Kleinova, Angela and Spitalsky, Zdeno and Pavlović, Vladimir B. and Marković, Biljana M. Todorovic",
year = "2019",
abstract = "Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Photochemistry and Photobiology B-Biology",
title = "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines",
volume = "200",
doi = "10.1016/j.jphotobiol.2019.111647"
}

Marković, Z. M., Jovanović, S. P., Masković, P. Z., Mojsin, M., Stevanović, M., Danko, M., Micusik, M., Jovanović, D. J., Kleinova, A., Spitalsky, Z., Pavlović, V. B.,& Marković, B. M. T.. (2019). Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B-Biology
Elsevier Science Sa, Lausanne., 200.
https://doi.org/10.1016/j.jphotobiol.2019.111647

Marković ZM, Jovanović SP, Masković PZ, Mojsin M, Stevanović M, Danko M, Micusik M, Jovanović DJ, Kleinova A, Spitalsky Z, Pavlović VB, Marković BMT. Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B-Biology. 2019;200.
doi:10.1016/j.jphotobiol.2019.111647 .

Marković, Zoran M., Jovanović, Svetlana P., Masković, Pavle Z., Mojsin, Marija, Stevanović, Milena, Danko, Martin, Micusik, Matej, Jovanović, Dragana J., Kleinova, Angela, Spitalsky, Zdeno, Pavlović, Vladimir B., Marković, Biljana M. Todorovic, "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines" in Journal of Photochemistry and Photobiology B-Biology, 200 (2019),
https://doi.org/10.1016/j.jphotobiol.2019.111647 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Matijašević, Danka
AU  - Pavlović, Vladimir B.
AU  - Jovanović, Svetlana P.
AU  - Holclajtner-Antunović, Ivanka D.
AU  - Spitalsky, Zdenko
AU  - Micusik, Matej
AU  - Dramicanin, Miroslav D.
AU  - Milivojević, Dusan D.
AU  - Nikšić, Miomir
AU  - Marković, Biljana M. Todorovic
PY  - 2017
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1090
AB  - Electrochemically exfoliated graphene is functionalized graphene with potential application in biomedicine. Two most relevant biological features of this material are its electrical conductivity and excellent water dispersibility. In this study we have tried to establish the correlation between graphene structure and its antibacterial properties. The exfoliation process was performed in a two electrode-highly oriented pyrolytic graphite electrochemical cell. Solution of ammonium persulfate was used as an electrolyte. Exfoliated graphene sheets were dispersed in aqueous media and characterized by atomic force microscopy, scanning electron microscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, X photoelectron spectroscopy, X-ray diffraction, electron paramagnetic resonance, zeta potential, contact angle measurements and surface energy. Antibacterial assays have shown lack of the significant antibacterial activity. Major effect on bacteria was slight change of bacteria morphology. Membrane remained intact despite significant change of chemical content of membrane components.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Journal of Colloid and Interface Science
T1  - Antibacterial potential of electrochemically exfoliated graphene sheets
EP  - 43
SP  - 30
VL  - 500
DO  - 10.1016/j.jcis.2017.03.110
ER  - 

@article{
author = "Marković, Zoran M. and Matijašević, Danka and Pavlović, Vladimir B. and Jovanović, Svetlana P. and Holclajtner-Antunović, Ivanka D. and Spitalsky, Zdenko and Micusik, Matej and Dramicanin, Miroslav D. and Milivojević, Dusan D. and Nikšić, Miomir and Marković, Biljana M. Todorovic",
year = "2017",
abstract = "Electrochemically exfoliated graphene is functionalized graphene with potential application in biomedicine. Two most relevant biological features of this material are its electrical conductivity and excellent water dispersibility. In this study we have tried to establish the correlation between graphene structure and its antibacterial properties. The exfoliation process was performed in a two electrode-highly oriented pyrolytic graphite electrochemical cell. Solution of ammonium persulfate was used as an electrolyte. Exfoliated graphene sheets were dispersed in aqueous media and characterized by atomic force microscopy, scanning electron microscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, X photoelectron spectroscopy, X-ray diffraction, electron paramagnetic resonance, zeta potential, contact angle measurements and surface energy. Antibacterial assays have shown lack of the significant antibacterial activity. Major effect on bacteria was slight change of bacteria morphology. Membrane remained intact despite significant change of chemical content of membrane components.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Colloid and Interface Science",
title = "Antibacterial potential of electrochemically exfoliated graphene sheets",
pages = "43-30",
volume = "500",
doi = "10.1016/j.jcis.2017.03.110"
}

Marković, Z. M., Matijašević, D., Pavlović, V. B., Jovanović, S. P., Holclajtner-Antunović, I. D., Spitalsky, Z., Micusik, M., Dramicanin, M. D., Milivojević, D. D., Nikšić, M.,& Marković, B. M. T.. (2017). Antibacterial potential of electrochemically exfoliated graphene sheets. in Journal of Colloid and Interface Science
Academic Press Inc Elsevier Science, San Diego., 500, 30-43.
https://doi.org/10.1016/j.jcis.2017.03.110

Marković ZM, Matijašević D, Pavlović VB, Jovanović SP, Holclajtner-Antunović ID, Spitalsky Z, Micusik M, Dramicanin MD, Milivojević DD, Nikšić M, Marković BMT. Antibacterial potential of electrochemically exfoliated graphene sheets. in Journal of Colloid and Interface Science. 2017;500:30-43.
doi:10.1016/j.jcis.2017.03.110 .

Marković, Zoran M., Matijašević, Danka, Pavlović, Vladimir B., Jovanović, Svetlana P., Holclajtner-Antunović, Ivanka D., Spitalsky, Zdenko, Micusik, Matej, Dramicanin, Miroslav D., Milivojević, Dusan D., Nikšić, Miomir, Marković, Biljana M. Todorovic, "Antibacterial potential of electrochemically exfoliated graphene sheets" in Journal of Colloid and Interface Science, 500 (2017):30-43,
https://doi.org/10.1016/j.jcis.2017.03.110 . .