TY  - JOUR
AU  - Kojić, Milorad
AU  - Yang, HJ
AU  - Kostrub, CF
AU  - Pavletich, NP
AU  - Holloman, WK
PY  - 2003
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/186
AB  - DSS1 encodes a small acidic protein shown in recent structural studies to interact with the DNA binding domain of BRCA2. Here we report that an ortholog of DSS1 is present in Ustilago maydis and associates with Brh2, the BRCA2-related protein, thus recapitulating the protein partnership in this genetically amenable fungus. Mutants of U. maydis deleted of DSS1 are extremely radiation sensitive, deficient in recombination, defective in meiosis, and disturbed in genome stability; these phenotypes mirror previous observations of U. maydis mutants deficient in Brh2 or Rad51. These findings conclusively show that Dss1 constitutes a protein with a significant role in the recombinational repair pathway in U. maydis, and imply that it plays a similar key role in the recombination systems of organisms in which recombinational repair is BRCA2 dependent.
PB  - Cell Press, Cambridge
T2  - Molecular Cell
T1  - The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis
EP  - 1049
IS  - 4
SP  - 1043
VL  - 12
DO  - 10.1016/S1097-2765(03)00367-8
ER  - 

@article{
author = "Kojić, Milorad and Yang, HJ and Kostrub, CF and Pavletich, NP and Holloman, WK",
year = "2003",
abstract = "DSS1 encodes a small acidic protein shown in recent structural studies to interact with the DNA binding domain of BRCA2. Here we report that an ortholog of DSS1 is present in Ustilago maydis and associates with Brh2, the BRCA2-related protein, thus recapitulating the protein partnership in this genetically amenable fungus. Mutants of U. maydis deleted of DSS1 are extremely radiation sensitive, deficient in recombination, defective in meiosis, and disturbed in genome stability; these phenotypes mirror previous observations of U. maydis mutants deficient in Brh2 or Rad51. These findings conclusively show that Dss1 constitutes a protein with a significant role in the recombinational repair pathway in U. maydis, and imply that it plays a similar key role in the recombination systems of organisms in which recombinational repair is BRCA2 dependent.",
publisher = "Cell Press, Cambridge",
journal = "Molecular Cell",
title = "The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis",
pages = "1049-1043",
number = "4",
volume = "12",
doi = "10.1016/S1097-2765(03)00367-8"
}

Kojić, M., Yang, H., Kostrub, C., Pavletich, N.,& Holloman, W.. (2003). The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis. in Molecular Cell
Cell Press, Cambridge., 12(4), 1043-1049.
https://doi.org/10.1016/S1097-2765(03)00367-8

Kojić M, Yang H, Kostrub C, Pavletich N, Holloman W. The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis. in Molecular Cell. 2003;12(4):1043-1049.
doi:10.1016/S1097-2765(03)00367-8 .

Kojić, Milorad, Yang, HJ, Kostrub, CF, Pavletich, NP, Holloman, WK, "The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis" in Molecular Cell, 12, no. 4 (2003):1043-1049,
https://doi.org/10.1016/S1097-2765(03)00367-8 . .

TY  - JOUR
AU  - Kojić, Milorad
AU  - Kostrub, CF
AU  - Buchman, AR
AU  - Holloman, WK
PY  - 2002
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/163
AB  - In a screen for DNA repair-defective mutants in the fungus Ustilago maydis, a gene encoding a BRCA2 family member, designated here as Brh2, was identified. A brh2 null allele was found to be defective in allelic recombination, meiosis, and repair of gaps and ionizing radiation damage to the same extent as rad51. Frequent marker loss in meiosis and diploid formation suggested that genomic instability was associated with brh2. This notion was confirmed by molecular karyotype analysis, which revealed gross chromosomal alterations associated with brh2. Yeast two-hybrid analysis indicated interaction between Brh2 and Rad51. Recapitulation in U. maydis of defects in DNA repair and genome stability associated with brh2 means that the BRCA2 gene family is more widespread than previously thought.
PB  - Cell Press, Cambridge
T2  - Molecular Cell
T1  - BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis
EP  - 691
IS  - 3
SP  - 683
VL  - 10
DO  - 10.1016/S1097-2765(02)00632-9
ER  - 

@article{
author = "Kojić, Milorad and Kostrub, CF and Buchman, AR and Holloman, WK",
year = "2002",
abstract = "In a screen for DNA repair-defective mutants in the fungus Ustilago maydis, a gene encoding a BRCA2 family member, designated here as Brh2, was identified. A brh2 null allele was found to be defective in allelic recombination, meiosis, and repair of gaps and ionizing radiation damage to the same extent as rad51. Frequent marker loss in meiosis and diploid formation suggested that genomic instability was associated with brh2. This notion was confirmed by molecular karyotype analysis, which revealed gross chromosomal alterations associated with brh2. Yeast two-hybrid analysis indicated interaction between Brh2 and Rad51. Recapitulation in U. maydis of defects in DNA repair and genome stability associated with brh2 means that the BRCA2 gene family is more widespread than previously thought.",
publisher = "Cell Press, Cambridge",
journal = "Molecular Cell",
title = "BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis",
pages = "691-683",
number = "3",
volume = "10",
doi = "10.1016/S1097-2765(02)00632-9"
}

Kojić, M., Kostrub, C., Buchman, A.,& Holloman, W.. (2002). BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis. in Molecular Cell
Cell Press, Cambridge., 10(3), 683-691.
https://doi.org/10.1016/S1097-2765(02)00632-9

Kojić M, Kostrub C, Buchman A, Holloman W. BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis. in Molecular Cell. 2002;10(3):683-691.
doi:10.1016/S1097-2765(02)00632-9 .

Kojić, Milorad, Kostrub, CF, Buchman, AR, Holloman, WK, "BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis" in Molecular Cell, 10, no. 3 (2002):683-691,
https://doi.org/10.1016/S1097-2765(02)00632-9 . .