TY  - CONF
AU  - Ašanin P., Darko
AU  - Vojnović, Sandra
AU  - Andrejević P., Tina
AU  - Marković R., Violeta
AU  - Perdih, Franc
AU  - Turel, Iztok
AU  - Djuran I., Miloš
AU  - Nikodinović-Runić, Jasmina
AU  - Glišić Đ., Biljana
PY  - 2023
UR  - https://isabc2023.com/
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1925
AB  - Cisplatin is one of the most used anticancer agents, and along with carboplatin and
oxaliplatin, is a part of more than 50% of clinically applied anticancer regimens [1]. However,
the side effects of cisplatin are severe and include dose-limiting toxicity, such as neurotoxicity,
nephrotoxicity and ototoxicity. Platinum(II) complexes with different structure from cisplatin
provide many opportunities for design of novel antitumor drugs with improved
pharmacological properties. Considering this, in the present study, new platinum(II) complexes
with phenothiazine (phtz) and N-methylphenothiazine (N-Mephtz), [PtCl2(phtz)(CH3CN)] (1)
and [PtCl2(N-Mephtz)(CH3CN)] (2), were synthesized. These complexes were characterized by
elemental microanalysis, NMR (1H and 13C) and IR spectroscopic measurements, while the
structure of complex 1 was determined by single-crystal X-ray diffraction analysis. The
antitumor activity of the platinum(II) complexes was tested in vitro against a panel of human
cancer cell lines, including A549 (lung cancer), A375 (melanoma, skin cancer), MDA-MB-231
(breast cancer), and HCT116 (colon cancer). To check the selectivity of the synthesized
complexes 1 and 2, a healthy MRC-5 cell line (lung fibroblasts) was also included in this study.
PB  - Greece : University of Ioannina
C3  - 16th International Symposium on Applied Bioinorganic Chemistry
T1  - Structural characterization and antitumor activity of platinum(II) complexes with phenothiazine and N-methylphenothiazine
SP  - 195
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1925
ER  - 

@conference{
author = "Ašanin P., Darko and Vojnović, Sandra and Andrejević P., Tina and Marković R., Violeta and Perdih, Franc and Turel, Iztok and Djuran I., Miloš and Nikodinović-Runić, Jasmina and Glišić Đ., Biljana",
year = "2023",
abstract = "Cisplatin is one of the most used anticancer agents, and along with carboplatin and
oxaliplatin, is a part of more than 50% of clinically applied anticancer regimens [1]. However,
the side effects of cisplatin are severe and include dose-limiting toxicity, such as neurotoxicity,
nephrotoxicity and ototoxicity. Platinum(II) complexes with different structure from cisplatin
provide many opportunities for design of novel antitumor drugs with improved
pharmacological properties. Considering this, in the present study, new platinum(II) complexes
with phenothiazine (phtz) and N-methylphenothiazine (N-Mephtz), [PtCl2(phtz)(CH3CN)] (1)
and [PtCl2(N-Mephtz)(CH3CN)] (2), were synthesized. These complexes were characterized by
elemental microanalysis, NMR (1H and 13C) and IR spectroscopic measurements, while the
structure of complex 1 was determined by single-crystal X-ray diffraction analysis. The
antitumor activity of the platinum(II) complexes was tested in vitro against a panel of human
cancer cell lines, including A549 (lung cancer), A375 (melanoma, skin cancer), MDA-MB-231
(breast cancer), and HCT116 (colon cancer). To check the selectivity of the synthesized
complexes 1 and 2, a healthy MRC-5 cell line (lung fibroblasts) was also included in this study.",
publisher = "Greece : University of Ioannina",
journal = "16th International Symposium on Applied Bioinorganic Chemistry",
title = "Structural characterization and antitumor activity of platinum(II) complexes with phenothiazine and N-methylphenothiazine",
pages = "195",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1925"
}

Ašanin P., D., Vojnović, S., Andrejević P., T., Marković R., V., Perdih, F., Turel, I., Djuran I., M., Nikodinović-Runić, J.,& Glišić Đ., B.. (2023). Structural characterization and antitumor activity of platinum(II) complexes with phenothiazine and N-methylphenothiazine. in 16th International Symposium on Applied Bioinorganic Chemistry
Greece : University of Ioannina., 195.
https://hdl.handle.net/21.15107/rcub_imagine_1925

Ašanin P. D, Vojnović S, Andrejević P. T, Marković R. V, Perdih F, Turel I, Djuran I. M, Nikodinović-Runić J, Glišić Đ. B. Structural characterization and antitumor activity of platinum(II) complexes with phenothiazine and N-methylphenothiazine. in 16th International Symposium on Applied Bioinorganic Chemistry. 2023;:195.
https://hdl.handle.net/21.15107/rcub_imagine_1925 .

Ašanin P., Darko, Vojnović, Sandra, Andrejević P., Tina, Marković R., Violeta, Perdih, Franc, Turel, Iztok, Djuran I., Miloš, Nikodinović-Runić, Jasmina, Glišić Đ., Biljana, "Structural characterization and antitumor activity of platinum(II) complexes with phenothiazine and N-methylphenothiazine" in 16th International Symposium on Applied Bioinorganic Chemistry (2023):195,
https://hdl.handle.net/21.15107/rcub_imagine_1925 .