TY  - JOUR
AU  - Jaković, Ljubomir
AU  - Fekete, Marija Dencic
AU  - Virijević, Marijana
AU  - Kraguljac Kurtović, Nada
AU  - Todorić-Zivanović, Biljana
AU  - Stamatović, Dragana
AU  - Karan-Đurašević, Teodora
AU  - Pavlović, Sonja
AU  - Leković, Danijela
AU  - Bogdanović, Andrija
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1592
AB  - De novo AMLs with typical nonrandom chromosomal abnormalities are often associated with specific morphology subtypes. The t(8;21) is one of the most prominent recurrent cytogenetic aberrations (RCA) in AML, frequently associated with AML with maturation, and is characterized as a good prognostic marker. On the contrary, BCR::ABL1 rearrangement is rarely observed in AMLs, without specific morphology, carrying poor prognosis. Its distinction from blastic transformation of chronic myeloid leukemia has been a matter of long debate. The revised WHO classification (2016) recognized AML with BCR::ABL1(+) as a provisional entity. The occurrence of additional cytogenetic aberrations in AML RCA within the same leukemic clone has been detected, albeit rare cases of BCR::ABL1(+) were reported, mainly as subclones. Those additional cytogenetic and molecular findings seem to significantly affect patient prognosis. Conventional cytogenetic analysis, fluorescent in situ hybridization (FISH), and polymerase chain reaction (PCR) were applied at presentation and during the follow-up of the patient. We present a 34-year-old male patient with de novo AML harboring concomitant t(8;21) and t(9;22) in a single clone. The presence of both t(8;21) and Philadelphia chromosome (Ph+) in the same metaphases but in less than 100% of the analyzed cells, the p190 BCR::ABL transcript type, and absence of splenomegaly support that additional BCR::ABL1(+) is a part of the main leukemic clone. These findings, accompanied with an encouraging outcome of continuous cytogenetic and molecular remission after induction therapy, support BCR::ABL1 being a secondary genetic event in AML with t(8;21).
PB  - Heidelberg : Springer
T2  - Journal of Hematopathology
T1  - De novo acute myeloid leukemia harboring concomitant t(8;21)(q22;q22);RUNX1::RUNX1T1 and BCR::ABL1 (p190 minor transcript)
EP  - 195
IS  - 3
SP  - 191
VL  - 15
DO  - 10.1007/s12308-022-00509-4
ER  - 

@article{
author = "Jaković, Ljubomir and Fekete, Marija Dencic and Virijević, Marijana and Kraguljac Kurtović, Nada and Todorić-Zivanović, Biljana and Stamatović, Dragana and Karan-Đurašević, Teodora and Pavlović, Sonja and Leković, Danijela and Bogdanović, Andrija",
year = "2022",
abstract = "De novo AMLs with typical nonrandom chromosomal abnormalities are often associated with specific morphology subtypes. The t(8;21) is one of the most prominent recurrent cytogenetic aberrations (RCA) in AML, frequently associated with AML with maturation, and is characterized as a good prognostic marker. On the contrary, BCR::ABL1 rearrangement is rarely observed in AMLs, without specific morphology, carrying poor prognosis. Its distinction from blastic transformation of chronic myeloid leukemia has been a matter of long debate. The revised WHO classification (2016) recognized AML with BCR::ABL1(+) as a provisional entity. The occurrence of additional cytogenetic aberrations in AML RCA within the same leukemic clone has been detected, albeit rare cases of BCR::ABL1(+) were reported, mainly as subclones. Those additional cytogenetic and molecular findings seem to significantly affect patient prognosis. Conventional cytogenetic analysis, fluorescent in situ hybridization (FISH), and polymerase chain reaction (PCR) were applied at presentation and during the follow-up of the patient. We present a 34-year-old male patient with de novo AML harboring concomitant t(8;21) and t(9;22) in a single clone. The presence of both t(8;21) and Philadelphia chromosome (Ph+) in the same metaphases but in less than 100% of the analyzed cells, the p190 BCR::ABL transcript type, and absence of splenomegaly support that additional BCR::ABL1(+) is a part of the main leukemic clone. These findings, accompanied with an encouraging outcome of continuous cytogenetic and molecular remission after induction therapy, support BCR::ABL1 being a secondary genetic event in AML with t(8;21).",
publisher = "Heidelberg : Springer",
journal = "Journal of Hematopathology",
title = "De novo acute myeloid leukemia harboring concomitant t(8;21)(q22;q22);RUNX1::RUNX1T1 and BCR::ABL1 (p190 minor transcript)",
pages = "195-191",
number = "3",
volume = "15",
doi = "10.1007/s12308-022-00509-4"
}

Jaković, L., Fekete, M. D., Virijević, M., Kraguljac Kurtović, N., Todorić-Zivanović, B., Stamatović, D., Karan-Đurašević, T., Pavlović, S., Leković, D.,& Bogdanović, A.. (2022). De novo acute myeloid leukemia harboring concomitant t(8;21)(q22;q22);RUNX1::RUNX1T1 and BCR::ABL1 (p190 minor transcript). in Journal of Hematopathology
Heidelberg : Springer., 15(3), 191-195.
https://doi.org/10.1007/s12308-022-00509-4

Jaković L, Fekete MD, Virijević M, Kraguljac Kurtović N, Todorić-Zivanović B, Stamatović D, Karan-Đurašević T, Pavlović S, Leković D, Bogdanović A. De novo acute myeloid leukemia harboring concomitant t(8;21)(q22;q22);RUNX1::RUNX1T1 and BCR::ABL1 (p190 minor transcript). in Journal of Hematopathology. 2022;15(3):191-195.
doi:10.1007/s12308-022-00509-4 .

Jaković, Ljubomir, Fekete, Marija Dencic, Virijević, Marijana, Kraguljac Kurtović, Nada, Todorić-Zivanović, Biljana, Stamatović, Dragana, Karan-Đurašević, Teodora, Pavlović, Sonja, Leković, Danijela, Bogdanović, Andrija, "De novo acute myeloid leukemia harboring concomitant t(8;21)(q22;q22);RUNX1::RUNX1T1 and BCR::ABL1 (p190 minor transcript)" in Journal of Hematopathology, 15, no. 3 (2022):191-195,
https://doi.org/10.1007/s12308-022-00509-4 . .

TY  - CONF
AU  - Fekete, Marija Dencic
AU  - Jaković, Ljubomir
AU  - Virijević, Marijana
AU  - Jovanović, Jelica
AU  - Todorić-Zivanović, Biljana
AU  - Karan-Đurašević, Teodora
AU  - Kraguljac-Kurtović, Nada
AU  - Pavlović, Sonja
AU  - Bogdanović, Andrija
PY  - 2019
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1249
PB  - BMC, London
C3  - Molecular Cytogenetics
T1  - P1143-De novo acute myeloid leukemia with BCR ABL1 accompanied by t(8;21)(q22;q22.1) RUNX1 RUNX1T1 a rare association
VL  - 12
UR  - https://hdl.handle.net/21.15107/rcub_imagine_1249
ER  - 

@conference{
author = "Fekete, Marija Dencic and Jaković, Ljubomir and Virijević, Marijana and Jovanović, Jelica and Todorić-Zivanović, Biljana and Karan-Đurašević, Teodora and Kraguljac-Kurtović, Nada and Pavlović, Sonja and Bogdanović, Andrija",
year = "2019",
publisher = "BMC, London",
journal = "Molecular Cytogenetics",
title = "P1143-De novo acute myeloid leukemia with BCR ABL1 accompanied by t(8;21)(q22;q22.1) RUNX1 RUNX1T1 a rare association",
volume = "12",
url = "https://hdl.handle.net/21.15107/rcub_imagine_1249"
}

Fekete, M. D., Jaković, L., Virijević, M., Jovanović, J., Todorić-Zivanović, B., Karan-Đurašević, T., Kraguljac-Kurtović, N., Pavlović, S.,& Bogdanović, A.. (2019). P1143-De novo acute myeloid leukemia with BCR ABL1 accompanied by t(8;21)(q22;q22.1) RUNX1 RUNX1T1 a rare association. in Molecular Cytogenetics
BMC, London., 12.
https://hdl.handle.net/21.15107/rcub_imagine_1249

Fekete MD, Jaković L, Virijević M, Jovanović J, Todorić-Zivanović B, Karan-Đurašević T, Kraguljac-Kurtović N, Pavlović S, Bogdanović A. P1143-De novo acute myeloid leukemia with BCR ABL1 accompanied by t(8;21)(q22;q22.1) RUNX1 RUNX1T1 a rare association. in Molecular Cytogenetics. 2019;12.
https://hdl.handle.net/21.15107/rcub_imagine_1249 .

Fekete, Marija Dencic, Jaković, Ljubomir, Virijević, Marijana, Jovanović, Jelica, Todorić-Zivanović, Biljana, Karan-Đurašević, Teodora, Kraguljac-Kurtović, Nada, Pavlović, Sonja, Bogdanović, Andrija, "P1143-De novo acute myeloid leukemia with BCR ABL1 accompanied by t(8;21)(q22;q22.1) RUNX1 RUNX1T1 a rare association" in Molecular Cytogenetics, 12 (2019),
https://hdl.handle.net/21.15107/rcub_imagine_1249 .