TY  - JOUR
AU  - Belij, Sandra
AU  - Miljković, Djordje
AU  - Popov, Aleksandra
AU  - Subota, Vesna
AU  - Timotijević, Gordana
AU  - Slavić, Marija
AU  - Mirkov, Ivana
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2012
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/545
AB  - Warfarin affects mainly vitamin K dependent (VKD) processes, but the effects on some non-VKD-related activities such as tumor growth inhibition and mononuclear cell-mediated immune reactions were shown as well. In this study, the effect of subchronic (30 days) oral warfarin (0.35 mg/l and 3.5 mg/l) intake on peripheral blood granulocytes in rats was investigated. Increase in prothrombin and partial thromboplastin time at high warfarin dose reflected its basic activity. Priming effect for respiratory burst was noted at both warfarin doses, while only high warfarin dose resulted in priming for adhesion, the rise in intracellular myeloperoxidase content/release and stimulation of nitric oxide production. Differential effects of high warfarin dose were noted on granulocyte cytokines IL-6 (lack of the effect), TNF-alpha (decreased release and mRNA expression) and IL-12 (increase in mRNA for IL-12 subunits p35 and p40). Changes in granulocytes seems not to rely on mitogen activated kinases p38 and ERK. Warfarin intake was associated with an increase in circulating IL-6, fibrinogen and haptoglobin and with changes in the activity of erythrocyte antioxidant enzymes superoxide dismutase and catalase. The effects of oral warfarin intake on peripheral blood granulocytes demonstrated in this study might be relevant for oral anticoagulant therapy strategies in humans.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats
EP  - 1507
IS  - 5
SP  - 1499
VL  - 50
DO  - 10.1016/j.fct.2012.01.049
ER  - 

@article{
author = "Belij, Sandra and Miljković, Djordje and Popov, Aleksandra and Subota, Vesna and Timotijević, Gordana and Slavić, Marija and Mirkov, Ivana and Kataranovski, Dragan and Kataranovski, Milena",
year = "2012",
abstract = "Warfarin affects mainly vitamin K dependent (VKD) processes, but the effects on some non-VKD-related activities such as tumor growth inhibition and mononuclear cell-mediated immune reactions were shown as well. In this study, the effect of subchronic (30 days) oral warfarin (0.35 mg/l and 3.5 mg/l) intake on peripheral blood granulocytes in rats was investigated. Increase in prothrombin and partial thromboplastin time at high warfarin dose reflected its basic activity. Priming effect for respiratory burst was noted at both warfarin doses, while only high warfarin dose resulted in priming for adhesion, the rise in intracellular myeloperoxidase content/release and stimulation of nitric oxide production. Differential effects of high warfarin dose were noted on granulocyte cytokines IL-6 (lack of the effect), TNF-alpha (decreased release and mRNA expression) and IL-12 (increase in mRNA for IL-12 subunits p35 and p40). Changes in granulocytes seems not to rely on mitogen activated kinases p38 and ERK. Warfarin intake was associated with an increase in circulating IL-6, fibrinogen and haptoglobin and with changes in the activity of erythrocyte antioxidant enzymes superoxide dismutase and catalase. The effects of oral warfarin intake on peripheral blood granulocytes demonstrated in this study might be relevant for oral anticoagulant therapy strategies in humans.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats",
pages = "1507-1499",
number = "5",
volume = "50",
doi = "10.1016/j.fct.2012.01.049"
}

Belij, S., Miljković, D., Popov, A., Subota, V., Timotijević, G., Slavić, M., Mirkov, I., Kataranovski, D.,& Kataranovski, M.. (2012). Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 50(5), 1499-1507.
https://doi.org/10.1016/j.fct.2012.01.049

Belij S, Miljković D, Popov A, Subota V, Timotijević G, Slavić M, Mirkov I, Kataranovski D, Kataranovski M. Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats. in Food and Chemical Toxicology. 2012;50(5):1499-1507.
doi:10.1016/j.fct.2012.01.049 .

Belij, Sandra, Miljković, Djordje, Popov, Aleksandra, Subota, Vesna, Timotijević, Gordana, Slavić, Marija, Mirkov, Ivana, Kataranovski, Dragan, Kataranovski, Milena, "Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats" in Food and Chemical Toxicology, 50, no. 5 (2012):1499-1507,
https://doi.org/10.1016/j.fct.2012.01.049 . .