TY  - JOUR
AU  - Mijatović, Sanja A.
AU  - Timotijević, Gordana
AU  - Miljković, Djordje M.
AU  - Radović, Julijana M.
AU  - Maksimović-Ivanić, Danijela
AU  - Dekanski, Dragana P.
AU  - Stošić-Grujičić, Stanislava
PY  - 2011
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/486
AB  - Various constituents of the olive tree (Olea europaea) have been traditionally used in the treatment of infection, inflammation, prevention of chronic diseases, cardiovascular disorders and cancer. The anticancer potential of dry olive leaf extract (DOLE) represents the net effect of multilevel interactions between different biologically active compounds from the extract, cancer cells and conventional therapy. In this context, it was of primary interest to evaluate the influence of DOLE on progression of the highly malignant, immuno-and chemoresistant type of skin cancer-melanoma. DOLE significantly inhibited proliferation and subsequently restricted clonogenicity of the B16 mouse melanoma cell line in vitro. Moreover, late phase tumor treatment with DOLE significantly reduced tumor volume in a syngeneic strain of mice. DOLE-treated B16 cells were blocked in the G(0)/G(1) phase of the cell cycle, underwent early apoptosis and died by late necrosis. At the molecular level, the dying process started as caspase dependent, but finalized as caspase independent. In concordance, overexpression of antiapoptotic members of the Bcl-2 family, Bcl-2 and Bcl-XL, and diminished expression of their natural antagonists, Bim and p53, were observed. Despite molecular suppression of the proapoptotic process, DOLE successfully promoted cell death mainly through disruption of cell membrane integrity and late caspase-independent fragmentation of genetic material. Taken together, the results of this study indicate that DOLE possesses strong antimelanoma potential. When DOLE was applied in combination with different chemotherapeutics, various outcomes, including synergy and antagonism, were observed. This requires caution in the use of the extract as a supplementary antitumor therapeutic.
PB  - Wiley, Hoboken
T2  - International Journal of Cancer
T1  - Multiple antimelanoma potential of dry olive leaf extract
EP  - 1965
IS  - 8
SP  - 1955
VL  - 128
DO  - 10.1002/ijc.25526
ER  - 

@article{
author = "Mijatović, Sanja A. and Timotijević, Gordana and Miljković, Djordje M. and Radović, Julijana M. and Maksimović-Ivanić, Danijela and Dekanski, Dragana P. and Stošić-Grujičić, Stanislava",
year = "2011",
abstract = "Various constituents of the olive tree (Olea europaea) have been traditionally used in the treatment of infection, inflammation, prevention of chronic diseases, cardiovascular disorders and cancer. The anticancer potential of dry olive leaf extract (DOLE) represents the net effect of multilevel interactions between different biologically active compounds from the extract, cancer cells and conventional therapy. In this context, it was of primary interest to evaluate the influence of DOLE on progression of the highly malignant, immuno-and chemoresistant type of skin cancer-melanoma. DOLE significantly inhibited proliferation and subsequently restricted clonogenicity of the B16 mouse melanoma cell line in vitro. Moreover, late phase tumor treatment with DOLE significantly reduced tumor volume in a syngeneic strain of mice. DOLE-treated B16 cells were blocked in the G(0)/G(1) phase of the cell cycle, underwent early apoptosis and died by late necrosis. At the molecular level, the dying process started as caspase dependent, but finalized as caspase independent. In concordance, overexpression of antiapoptotic members of the Bcl-2 family, Bcl-2 and Bcl-XL, and diminished expression of their natural antagonists, Bim and p53, were observed. Despite molecular suppression of the proapoptotic process, DOLE successfully promoted cell death mainly through disruption of cell membrane integrity and late caspase-independent fragmentation of genetic material. Taken together, the results of this study indicate that DOLE possesses strong antimelanoma potential. When DOLE was applied in combination with different chemotherapeutics, various outcomes, including synergy and antagonism, were observed. This requires caution in the use of the extract as a supplementary antitumor therapeutic.",
publisher = "Wiley, Hoboken",
journal = "International Journal of Cancer",
title = "Multiple antimelanoma potential of dry olive leaf extract",
pages = "1965-1955",
number = "8",
volume = "128",
doi = "10.1002/ijc.25526"
}

Mijatović, S. A., Timotijević, G., Miljković, D. M., Radović, J. M., Maksimović-Ivanić, D., Dekanski, D. P.,& Stošić-Grujičić, S.. (2011). Multiple antimelanoma potential of dry olive leaf extract. in International Journal of Cancer
Wiley, Hoboken., 128(8), 1955-1965.
https://doi.org/10.1002/ijc.25526

Mijatović SA, Timotijević G, Miljković DM, Radović JM, Maksimović-Ivanić D, Dekanski DP, Stošić-Grujičić S. Multiple antimelanoma potential of dry olive leaf extract. in International Journal of Cancer. 2011;128(8):1955-1965.
doi:10.1002/ijc.25526 .

Mijatović, Sanja A., Timotijević, Gordana, Miljković, Djordje M., Radović, Julijana M., Maksimović-Ivanić, Danijela, Dekanski, Dragana P., Stošić-Grujičić, Stanislava, "Multiple antimelanoma potential of dry olive leaf extract" in International Journal of Cancer, 128, no. 8 (2011):1955-1965,
https://doi.org/10.1002/ijc.25526 . .

TY  - CONF
AU  - Mijatović, S.
AU  - Radović, J.
AU  - Timotijević, Gordana
AU  - Mojić, M.
AU  - Miljković, D.
AU  - Dekanski, D.
AU  - Stošić-Grujičić, Stanislava
PY  - 2009
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/349
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway
EP  - 903
IS  - 9
SP  - 903
VL  - 75
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1443
ER  - 

@conference{
author = "Mijatović, S. and Radović, J. and Timotijević, Gordana and Mojić, M. and Miljković, D. and Dekanski, D. and Stošić-Grujičić, Stanislava",
year = "2009",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway",
pages = "903-903",
number = "9",
volume = "75",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1443"
}

Mijatović, S., Radović, J., Timotijević, G., Mojić, M., Miljković, D., Dekanski, D.,& Stošić-Grujičić, S.. (2009). Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 75(9), 903-903.
https://hdl.handle.net/21.15107/rcub_ibiss_1443

Mijatović S, Radović J, Timotijević G, Mojić M, Miljković D, Dekanski D, Stošić-Grujičić S. Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway. in Planta Medica. 2009;75(9):903-903.
https://hdl.handle.net/21.15107/rcub_ibiss_1443 .

Mijatović, S., Radović, J., Timotijević, Gordana, Mojić, M., Miljković, D., Dekanski, D., Stošić-Grujičić, Stanislava, "Dry olive leaf extract promotes avant-garde apoptosis in melanoma cells; switch from caspase- dependent to caspase- independent pathway" in Planta Medica, 75, no. 9 (2009):903-903,
https://hdl.handle.net/21.15107/rcub_ibiss_1443 .