TY  - JOUR
AU  - Nikčević, Gordana
AU  - Kovačević Grujičić, Nataša
AU  - Mojsin, Marija
AU  - Krstić, A.
AU  - Savić, T.
AU  - Stevanović, Milena
PY  - 2011
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/485
AB  - Sox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates. Despite the mounting evidence that Sox3/SOX3 is one of the key players in the development of the nervous system, limited data are available regarding the transcriptional regulation of its expression. This review is focused on the retinoic acid induced regulation of SOX3 gene expression, with particular emphasis on the involvement of retinoid receptors. Experiments with human embryonal carcinoma cells identified two response elements involved in retinoic acid/retinoid X receptor-dependent activation of the SOX3 gene expression: distal atypical retinoic acid-response element, consisting of two unique G-rich boxes separated by 49 bp, and proximal element comprising DR-3-like motif, composed of two imperfect hexameric half-sites. Importantly, the retinoic acid-induced SOX3 gene expression could be significantly down-regulated by a synthetic antagonist of retinoid receptors. This cell model provides a solid base for further studies on mechanism(s) underlying regulation of expression of SOX3 gene, which could improve the understanding of molecular signals that induce neurogenesis in the stem/progenitor cells both during development and in adulthood.
PB  - Acad Sciences Czech Republic, Inst Physiology, Prague 4
T2  - Physiological Research
T1  - Regulation of the SOX3 Gene Expression by Retinoid Receptors
EP  - S91
SP  - S83
VL  - 60
DO  - 10.33549/physiolres.932184
ER  - 

@article{
author = "Nikčević, Gordana and Kovačević Grujičić, Nataša and Mojsin, Marija and Krstić, A. and Savić, T. and Stevanović, Milena",
year = "2011",
abstract = "Sox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates. Despite the mounting evidence that Sox3/SOX3 is one of the key players in the development of the nervous system, limited data are available regarding the transcriptional regulation of its expression. This review is focused on the retinoic acid induced regulation of SOX3 gene expression, with particular emphasis on the involvement of retinoid receptors. Experiments with human embryonal carcinoma cells identified two response elements involved in retinoic acid/retinoid X receptor-dependent activation of the SOX3 gene expression: distal atypical retinoic acid-response element, consisting of two unique G-rich boxes separated by 49 bp, and proximal element comprising DR-3-like motif, composed of two imperfect hexameric half-sites. Importantly, the retinoic acid-induced SOX3 gene expression could be significantly down-regulated by a synthetic antagonist of retinoid receptors. This cell model provides a solid base for further studies on mechanism(s) underlying regulation of expression of SOX3 gene, which could improve the understanding of molecular signals that induce neurogenesis in the stem/progenitor cells both during development and in adulthood.",
publisher = "Acad Sciences Czech Republic, Inst Physiology, Prague 4",
journal = "Physiological Research",
title = "Regulation of the SOX3 Gene Expression by Retinoid Receptors",
pages = "S91-S83",
volume = "60",
doi = "10.33549/physiolres.932184"
}

Nikčević, G., Kovačević Grujičić, N., Mojsin, M., Krstić, A., Savić, T.,& Stevanović, M.. (2011). Regulation of the SOX3 Gene Expression by Retinoid Receptors. in Physiological Research
Acad Sciences Czech Republic, Inst Physiology, Prague 4., 60, S83-S91.
https://doi.org/10.33549/physiolres.932184

Nikčević G, Kovačević Grujičić N, Mojsin M, Krstić A, Savić T, Stevanović M. Regulation of the SOX3 Gene Expression by Retinoid Receptors. in Physiological Research. 2011;60:S83-S91.
doi:10.33549/physiolres.932184 .

Nikčević, Gordana, Kovačević Grujičić, Nataša, Mojsin, Marija, Krstić, A., Savić, T., Stevanović, Milena, "Regulation of the SOX3 Gene Expression by Retinoid Receptors" in Physiological Research, 60 (2011):S83-S91,
https://doi.org/10.33549/physiolres.932184 . .

TY  - CONF
AU  - Nikčević, Gordana
AU  - Mojsin, Marija
AU  - Kovačević Grujičić, Nataša
AU  - Krstić, A.
AU  - Savić, T.
AU  - Stevanović, Milena
PY  - 2008
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/300
PB  - Wiley-Blackwell, Malden
C3  - FEBS Journal
T1  - Delineation of the RXR response element(s) involved in retinoic acid induced transcriptional activation of the human SOX3 gene expression
EP  - 71
SP  - 71
VL  - 275
UR  - https://hdl.handle.net/21.15107/rcub_imagine_300
ER  - 

@conference{
author = "Nikčević, Gordana and Mojsin, Marija and Kovačević Grujičić, Nataša and Krstić, A. and Savić, T. and Stevanović, Milena",
year = "2008",
publisher = "Wiley-Blackwell, Malden",
journal = "FEBS Journal",
title = "Delineation of the RXR response element(s) involved in retinoic acid induced transcriptional activation of the human SOX3 gene expression",
pages = "71-71",
volume = "275",
url = "https://hdl.handle.net/21.15107/rcub_imagine_300"
}

Nikčević, G., Mojsin, M., Kovačević Grujičić, N., Krstić, A., Savić, T.,& Stevanović, M.. (2008). Delineation of the RXR response element(s) involved in retinoic acid induced transcriptional activation of the human SOX3 gene expression. in FEBS Journal
Wiley-Blackwell, Malden., 275, 71-71.
https://hdl.handle.net/21.15107/rcub_imagine_300

Nikčević G, Mojsin M, Kovačević Grujičić N, Krstić A, Savić T, Stevanović M. Delineation of the RXR response element(s) involved in retinoic acid induced transcriptional activation of the human SOX3 gene expression. in FEBS Journal. 2008;275:71-71.
https://hdl.handle.net/21.15107/rcub_imagine_300 .

Nikčević, Gordana, Mojsin, Marija, Kovačević Grujičić, Nataša, Krstić, A., Savić, T., Stevanović, Milena, "Delineation of the RXR response element(s) involved in retinoic acid induced transcriptional activation of the human SOX3 gene expression" in FEBS Journal, 275 (2008):71-71,
https://hdl.handle.net/21.15107/rcub_imagine_300 .