TY  - JOUR
AU  - Jovicić, N.
AU  - Babić, Tamara
AU  - Dragičević, Sandra
AU  - Nestorović, B.
AU  - Nikolić, Aleksandra
PY  - 2018
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1152
AB  - Inhaled beta 2 adrenergic receptor (beta 2-AR) agonists are the mainstay of asthma therapy. The beta 2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children's Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A gt G (Arg16Gly, rs1042713) and +79C gt G (G1n27G1u, rs1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +460 was found to be associated with a better response to inhaled salbutamol (p  lt 0.05) and with mild form of asthma (p  lt 0.05). Polymorphism ADRB2 +46A gt G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C gt G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.
PB  - Macedonian Acad Sciences Arts, Skopje
T2  - Balkan Journal of Medical Genetics
T1  - ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma
EP  - 38
IS  - 1
SP  - 33
VL  - 21
DO  - 10.2478/bjmg-2018-0007
ER  - 

@article{
author = "Jovicić, N. and Babić, Tamara and Dragičević, Sandra and Nestorović, B. and Nikolić, Aleksandra",
year = "2018",
abstract = "Inhaled beta 2 adrenergic receptor (beta 2-AR) agonists are the mainstay of asthma therapy. The beta 2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children's Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A gt G (Arg16Gly, rs1042713) and +79C gt G (G1n27G1u, rs1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +460 was found to be associated with a better response to inhaled salbutamol (p  lt 0.05) and with mild form of asthma (p  lt 0.05). Polymorphism ADRB2 +46A gt G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C gt G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.",
publisher = "Macedonian Acad Sciences Arts, Skopje",
journal = "Balkan Journal of Medical Genetics",
title = "ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma",
pages = "38-33",
number = "1",
volume = "21",
doi = "10.2478/bjmg-2018-0007"
}

Jovicić, N., Babić, T., Dragičević, S., Nestorović, B.,& Nikolić, A.. (2018). ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma. in Balkan Journal of Medical Genetics
Macedonian Acad Sciences Arts, Skopje., 21(1), 33-38.
https://doi.org/10.2478/bjmg-2018-0007

Jovicić N, Babić T, Dragičević S, Nestorović B, Nikolić A. ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma. in Balkan Journal of Medical Genetics. 2018;21(1):33-38.
doi:10.2478/bjmg-2018-0007 .

Jovicić, N., Babić, Tamara, Dragičević, Sandra, Nestorović, B., Nikolić, Aleksandra, "ADRB2 Gene Polymorphisms and Salbutamol Responsiveness in Serbian Children with Asthma" in Balkan Journal of Medical Genetics, 21, no. 1 (2018):33-38,
https://doi.org/10.2478/bjmg-2018-0007 . .