TY  - JOUR
AU  - Smederevac, Snežana
AU  - Delgado-Cruzata, Lissette
AU  - Mitrović, Dušanka
AU  - Dinić, Bojana M.
AU  - Bravo, Toni-Ann T.
AU  - Delgado, Maria
AU  - Bugarski Ignjatović, Vojislava
AU  - Sadiković, Selka
AU  - Milovanović, Ilija
AU  - Vučinić, Nataša
AU  - Branovački, Bojan
AU  - Prinz, Mechthild
AU  - Budimlija, Zoran
AU  - Kušić‐Tišma, Jelena
AU  - Nikolašević, Željka
PY  - 2023
UR  - https://www.frontiersin.org/articles/10.3389/fgene.2022.1067276
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1765
AB  - Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used pyrosequencing to determine DNAm of the regulatory region of membrane bound catechol-O-methyltransferase in saliva DNA. Results of intrapair differences in the percentage of membrane bound catechol-O-methyltransferase DNAm at each of five CpG sites show that there are associations between phenotypic indicators of lack of control and membrane bound catechol-O-methyltransferase DNAm differences on CpG1, CpG2 and CpG4, suggesting the common epigenetic patterns for personality traits, cognitive functions, and risk behaviors.
T2  - Frontiers in Genetics
T2  - Frontiers in Genetics
T1  - Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity
VL  - 13
DO  - 10.3389/fgene.2022.1067276
ER  - 

@article{
author = "Smederevac, Snežana and Delgado-Cruzata, Lissette and Mitrović, Dušanka and Dinić, Bojana M. and Bravo, Toni-Ann T. and Delgado, Maria and Bugarski Ignjatović, Vojislava and Sadiković, Selka and Milovanović, Ilija and Vučinić, Nataša and Branovački, Bojan and Prinz, Mechthild and Budimlija, Zoran and Kušić‐Tišma, Jelena and Nikolašević, Željka",
year = "2023",
abstract = "Epigenetic modifications of the membrane bound catechol-O-methyltransferase (MB-COMT) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used pyrosequencing to determine DNAm of the regulatory region of membrane bound catechol-O-methyltransferase in saliva DNA. Results of intrapair differences in the percentage of membrane bound catechol-O-methyltransferase DNAm at each of five CpG sites show that there are associations between phenotypic indicators of lack of control and membrane bound catechol-O-methyltransferase DNAm differences on CpG1, CpG2 and CpG4, suggesting the common epigenetic patterns for personality traits, cognitive functions, and risk behaviors.",
journal = "Frontiers in Genetics, Frontiers in Genetics",
title = "Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity",
volume = "13",
doi = "10.3389/fgene.2022.1067276"
}

Smederevac, S., Delgado-Cruzata, L., Mitrović, D., Dinić, B. M., Bravo, T. T., Delgado, M., Bugarski Ignjatović, V., Sadiković, S., Milovanović, I., Vučinić, N., Branovački, B., Prinz, M., Budimlija, Z., Kušić‐Tišma, J.,& Nikolašević, Ž.. (2023). Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity. in Frontiers in Genetics, 13.
https://doi.org/10.3389/fgene.2022.1067276

Smederevac S, Delgado-Cruzata L, Mitrović D, Dinić BM, Bravo TT, Delgado M, Bugarski Ignjatović V, Sadiković S, Milovanović I, Vučinić N, Branovački B, Prinz M, Budimlija Z, Kušić‐Tišma J, Nikolašević Ž. Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity. in Frontiers in Genetics. 2023;13.
doi:10.3389/fgene.2022.1067276 .

Smederevac, Snežana, Delgado-Cruzata, Lissette, Mitrović, Dušanka, Dinić, Bojana M., Bravo, Toni-Ann T., Delgado, Maria, Bugarski Ignjatović, Vojislava, Sadiković, Selka, Milovanović, Ilija, Vučinić, Nataša, Branovački, Bojan, Prinz, Mechthild, Budimlija, Zoran, Kušić‐Tišma, Jelena, Nikolašević, Željka, "Differences in MB-COMT DNA methylation in monozygotic twins on phenotypic indicators of impulsivity" in Frontiers in Genetics, 13 (2023),
https://doi.org/10.3389/fgene.2022.1067276 . .