TY  - JOUR
AU  - Jovicić, Dubravka
AU  - Milacić, Snežana
AU  - Vukov, Tanja D.
AU  - Rakić, Boban
AU  - Stevanović, Milena
AU  - Drakulić, Danijela
AU  - Rakić, Rada
AU  - Bukvić, Nenad
PY  - 2010
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/406
AB  - We have analyzed the frequency of premature centromeric division (PCD) in medical personnel professionally exposed to low doses of radiation. They had chromosome aberrations (CAs) involving dicentric chromosomes, ring chromosomes, acentric fragments, chromosome breaks, and chromatid breaks. The study included 30 exposed subjects and 23 controls who were each analyzed by a conventional cytogenetics procedure and subsequently by fluorescent in situ hybridization ( FISH). The latter was applied particularly in order to verify PCD in a specific chromosome ( chromosome 18) in both metaphases and interphase nuclei. The results revealed a significant difference (p  lt  0.001) in frequencies between the two groups ( exposed and controls) for all the observed variables ( CAs), metaphases with PCD (MPCD), total number of chromosomes with PCD (TPCD), number of PCD metaphases in acrocentric chromosomes (MAPCD), and the total number of acrocentric chromosomes with PCD (TAPCD). The doses of ionizing radiation absorbed by the subjects' bodies were measured with thermoluminescent dosimeters once a month during the duration of occupational exposure. They were expressed in mSv, as mean annual effective doses for the period of exposure. The Spearman rank test showed a high positive correlation between total life effective dose and frequency of CAs and PCD. Based on the results obtained in this study, we suggest that PCD, as a phenomenon manifesting chromosomal instability (CIN), should be considered as a suitable cytogenetic biomarker for individuals occupationally exposed to ionizing radiation. Health Phys. 98(5):717-726; 2010
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Health Physics
T1  - Detection of premature segregation of centromeres in persons exposed to ionizing radiation
EP  - 726
IS  - 5
SP  - 717
VL  - 98
DO  - 10.1097/HP.0b013e3181d26da1
ER  - 

@article{
author = "Jovicić, Dubravka and Milacić, Snežana and Vukov, Tanja D. and Rakić, Boban and Stevanović, Milena and Drakulić, Danijela and Rakić, Rada and Bukvić, Nenad",
year = "2010",
abstract = "We have analyzed the frequency of premature centromeric division (PCD) in medical personnel professionally exposed to low doses of radiation. They had chromosome aberrations (CAs) involving dicentric chromosomes, ring chromosomes, acentric fragments, chromosome breaks, and chromatid breaks. The study included 30 exposed subjects and 23 controls who were each analyzed by a conventional cytogenetics procedure and subsequently by fluorescent in situ hybridization ( FISH). The latter was applied particularly in order to verify PCD in a specific chromosome ( chromosome 18) in both metaphases and interphase nuclei. The results revealed a significant difference (p  lt  0.001) in frequencies between the two groups ( exposed and controls) for all the observed variables ( CAs), metaphases with PCD (MPCD), total number of chromosomes with PCD (TPCD), number of PCD metaphases in acrocentric chromosomes (MAPCD), and the total number of acrocentric chromosomes with PCD (TAPCD). The doses of ionizing radiation absorbed by the subjects' bodies were measured with thermoluminescent dosimeters once a month during the duration of occupational exposure. They were expressed in mSv, as mean annual effective doses for the period of exposure. The Spearman rank test showed a high positive correlation between total life effective dose and frequency of CAs and PCD. Based on the results obtained in this study, we suggest that PCD, as a phenomenon manifesting chromosomal instability (CIN), should be considered as a suitable cytogenetic biomarker for individuals occupationally exposed to ionizing radiation. Health Phys. 98(5):717-726; 2010",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Health Physics",
title = "Detection of premature segregation of centromeres in persons exposed to ionizing radiation",
pages = "726-717",
number = "5",
volume = "98",
doi = "10.1097/HP.0b013e3181d26da1"
}

Jovicić, D., Milacić, S., Vukov, T. D., Rakić, B., Stevanović, M., Drakulić, D., Rakić, R.,& Bukvić, N.. (2010). Detection of premature segregation of centromeres in persons exposed to ionizing radiation. in Health Physics
Lippincott Williams & Wilkins, Philadelphia., 98(5), 717-726.
https://doi.org/10.1097/HP.0b013e3181d26da1

Jovicić D, Milacić S, Vukov TD, Rakić B, Stevanović M, Drakulić D, Rakić R, Bukvić N. Detection of premature segregation of centromeres in persons exposed to ionizing radiation. in Health Physics. 2010;98(5):717-726.
doi:10.1097/HP.0b013e3181d26da1 .

Jovicić, Dubravka, Milacić, Snežana, Vukov, Tanja D., Rakić, Boban, Stevanović, Milena, Drakulić, Danijela, Rakić, Rada, Bukvić, Nenad, "Detection of premature segregation of centromeres in persons exposed to ionizing radiation" in Health Physics, 98, no. 5 (2010):717-726,
https://doi.org/10.1097/HP.0b013e3181d26da1 . .