TY  - JOUR
AU  - Ponjavić, Marijana
AU  - Nikolić, Marija S.
AU  - Jevtić, Sanja
AU  - Jeremić, Sanja
AU  - Đokić, Lidija
AU  - Donlagić, Jasna
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1580
AB  - The present study reports the potential application of star-shaped poly(epsilon-caprolactones) with different number of arms as new drug delivery matrix. Linear and star-shaped PCL ibuprofen loaded microspheres were prepared using oil-in-water (o/w) solvent evaporation technique and characterized with FTIR, DSC, XRD and SEM analysis. High yield, encapsulation efficiency and drug loadings were obtained for all microspheres. FTIR analysis revealed the existence of interactions between polymer matrix and drug, while the DSC analysis suggested that drug was encapsulated in an amorphous form. SEM analysis confirmed that regular, spherical in shape star-shaped microspheres, with diameter between 80 and 90 mu n, were obtained, while quite larger microspheres, 110 mu m, were prepared from linear PCL. The advantage of using starshaped PCL microspheres instead of linear PCL was seen from drug release profiles which demonstrated higher amount of drug released from star-shaped polymer matrix as a consequence of their branched, flexible structure. Microspheres prepared from the polymers with the most branched structure showed the highest amount of the released drug after 24 h. Finally, cytotoxicity tests, performed using normal human fibroblasts (MRCS), indicated the absence of cytotoxicity at lower concentrations of microspheres proving the great potential of star-shaped PCL systems in comparison to linear ones.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers
DO  - 10.2298/JSC220202032P
ER  - 

@article{
author = "Ponjavić, Marijana and Nikolić, Marija S. and Jevtić, Sanja and Jeremić, Sanja and Đokić, Lidija and Donlagić, Jasna",
year = "2022",
abstract = "The present study reports the potential application of star-shaped poly(epsilon-caprolactones) with different number of arms as new drug delivery matrix. Linear and star-shaped PCL ibuprofen loaded microspheres were prepared using oil-in-water (o/w) solvent evaporation technique and characterized with FTIR, DSC, XRD and SEM analysis. High yield, encapsulation efficiency and drug loadings were obtained for all microspheres. FTIR analysis revealed the existence of interactions between polymer matrix and drug, while the DSC analysis suggested that drug was encapsulated in an amorphous form. SEM analysis confirmed that regular, spherical in shape star-shaped microspheres, with diameter between 80 and 90 mu n, were obtained, while quite larger microspheres, 110 mu m, were prepared from linear PCL. The advantage of using starshaped PCL microspheres instead of linear PCL was seen from drug release profiles which demonstrated higher amount of drug released from star-shaped polymer matrix as a consequence of their branched, flexible structure. Microspheres prepared from the polymers with the most branched structure showed the highest amount of the released drug after 24 h. Finally, cytotoxicity tests, performed using normal human fibroblasts (MRCS), indicated the absence of cytotoxicity at lower concentrations of microspheres proving the great potential of star-shaped PCL systems in comparison to linear ones.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers",
doi = "10.2298/JSC220202032P"
}

Ponjavić, M., Nikolić, M. S., Jevtić, S., Jeremić, S., Đokić, L.,& Donlagić, J.. (2022). Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd..
https://doi.org/10.2298/JSC220202032P

Ponjavić M, Nikolić MS, Jevtić S, Jeremić S, Đokić L, Donlagić J. Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers. in Journal of the Serbian Chemical Society. 2022;.
doi:10.2298/JSC220202032P .

Ponjavić, Marijana, Nikolić, Marija S., Jevtić, Sanja, Jeremić, Sanja, Đokić, Lidija, Donlagić, Jasna, "Star-shaped poly(epsilon-caprolactones) with well-defined architecture as potential drug carriers" in Journal of the Serbian Chemical Society (2022),
https://doi.org/10.2298/JSC220202032P . .