TY  - JOUR
AU  - Kovac, Mirjana
AU  - Balint, Milena Todorovic
AU  - Milenković, Marija
AU  - Basaric, Dušica
AU  - Tomić, Branko
AU  - Balint, Bela
AU  - Ignjatović, Vera
PY  - 2024
UR  - http://www.thieme-connect.de/DOI/DOI?10.1055/a-2238-4744
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2329
AB  - Changes in the hemostatic system during COVID infection lead to hypercoagulability. Numerous studies have evaluated hemostatic abnormalities in COVID patients during acute infection, in the period of hospitalization. However, the hemostatic status following hospital discharge has not been sufficiently assessed. Considering the importance of FVIII and D-dimer levels as markers for the assessment of thrombosis, our study aimed to evaluate changes in these markers, as well as the influence of patient's age and clinical presentation of COVID infection on those hemostatic markers in the post-COVID phase. This prospective study (July 2020 to December 2022) included 115 COVID patients, 68 (59%) with asymptomatic/mild and 47 (41%) with moderate/severe clinical presentation. Patient follow-up included laboratory evaluation of FVIII and D-dimer levels at 1, 3, and 6 months following the COVID infection. Three months after the COVID infection, elevated FVIII was recorded in 44% of younger versus 65% of older individuals, p = 0.05, respectively, and 30 versus 57% (p = 0.008) 6 months post–COVID infection. With a focus on clinical presentation, a higher number of patients with moderate/severe COVID had elevated FVIII activity, but a statistically significant difference was observed only for the 6 months (32% mild vs. 53% moderate/severe, p = 0.041) post-infection time point. Following a COVID infection, an increase in FVIII activity suggests a continued hypercoagulable state in the post-COVID period and correlates with elevated D-dimer levels. This increase in FVIII is more pronounced in patients with moderate/severe clinical picture and those patients older than 50 years.
PB  - Georg Thieme Verlag KG
T2  - Hämostaseologie
T1  - Assessment of Factor VIII Activity and D-Dimer Levels in the Post-COVID Period
DO  - 10.1055/a-2238-4744
ER  - 

@article{
author = "Kovac, Mirjana and Balint, Milena Todorovic and Milenković, Marija and Basaric, Dušica and Tomić, Branko and Balint, Bela and Ignjatović, Vera",
year = "2024",
abstract = "Changes in the hemostatic system during COVID infection lead to hypercoagulability. Numerous studies have evaluated hemostatic abnormalities in COVID patients during acute infection, in the period of hospitalization. However, the hemostatic status following hospital discharge has not been sufficiently assessed. Considering the importance of FVIII and D-dimer levels as markers for the assessment of thrombosis, our study aimed to evaluate changes in these markers, as well as the influence of patient's age and clinical presentation of COVID infection on those hemostatic markers in the post-COVID phase. This prospective study (July 2020 to December 2022) included 115 COVID patients, 68 (59%) with asymptomatic/mild and 47 (41%) with moderate/severe clinical presentation. Patient follow-up included laboratory evaluation of FVIII and D-dimer levels at 1, 3, and 6 months following the COVID infection. Three months after the COVID infection, elevated FVIII was recorded in 44% of younger versus 65% of older individuals, p = 0.05, respectively, and 30 versus 57% (p = 0.008) 6 months post–COVID infection. With a focus on clinical presentation, a higher number of patients with moderate/severe COVID had elevated FVIII activity, but a statistically significant difference was observed only for the 6 months (32% mild vs. 53% moderate/severe, p = 0.041) post-infection time point. Following a COVID infection, an increase in FVIII activity suggests a continued hypercoagulable state in the post-COVID period and correlates with elevated D-dimer levels. This increase in FVIII is more pronounced in patients with moderate/severe clinical picture and those patients older than 50 years.",
publisher = "Georg Thieme Verlag KG",
journal = "Hämostaseologie",
title = "Assessment of Factor VIII Activity and D-Dimer Levels in the Post-COVID Period",
doi = "10.1055/a-2238-4744"
}

Kovac, M., Balint, M. T., Milenković, M., Basaric, D., Tomić, B., Balint, B.,& Ignjatović, V.. (2024). Assessment of Factor VIII Activity and D-Dimer Levels in the Post-COVID Period. in Hämostaseologie
Georg Thieme Verlag KG..
https://doi.org/10.1055/a-2238-4744

Kovac M, Balint MT, Milenković M, Basaric D, Tomić B, Balint B, Ignjatović V. Assessment of Factor VIII Activity and D-Dimer Levels in the Post-COVID Period. in Hämostaseologie. 2024;.
doi:10.1055/a-2238-4744 .

Kovac, Mirjana, Balint, Milena Todorovic, Milenković, Marija, Basaric, Dušica, Tomić, Branko, Balint, Bela, Ignjatović, Vera, "Assessment of Factor VIII Activity and D-Dimer Levels in the Post-COVID Period" in Hämostaseologie (2024),
https://doi.org/10.1055/a-2238-4744 . .