TY  - JOUR
AU  - Obradović, Jasmina
AU  - Đorđević, Nataša
AU  - Tošić, Nataša
AU  - Mrdjanović, Jasminka
AU  - Stanković, Biljana
AU  - Stanić, Jelena
AU  - Zarić, Bojan
AU  - Perin, Branislav
AU  - Pavlović, Sonja
AU  - Jurisić, Vladimir
PY  - 2016
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/902
AB  - The purpose of this study was to determine the frequencies of EGFR -216G  gt  T, -191C  gt  A, and 181946C  gt  T in Serbian non-small cell lung cancer (NSCLC) patients, as well as to compare it with healthy individuals, in order to assess their potential importance for lung cancer in Serbia. The study involved 56 NSCLC patients and 53 unrelated healthy volunteers, and genotyping was performed on DNA samples obtained from formalin-fixed paraffin-embedded lung tumor tissue and blood, respectively. This was the first time to show genotype frequencies of those single nucleotide polymorphisms for this study group from the territory of the Republic of Serbia. There was very strong evidence of association between age and death due to lung cancer (Pearson chi-square = 43.439, df = 2, p  lt  0,001), as well as between ever smoking and death due to lung cancer (Pearson chi-square = 31.727, df = 1, p  lt  0.001). When dominant genetic model (GG vs. GT+TT) was used for -216G  gt  T, we have found significant association (p = 0.012) between -216GG genotype and NSCLC patients within smokers' subgroup. So, carriers of -216GG genotype had higher risk (OR = 4.33, 95 % CI = 1.324-14.179) than noncarriers (GT and TT) for developing non-small cell lung cancer in our patients.
PB  - Sage Publications Ltd, London
T2  - Tumor Biology
T1  - Frequencies of EGFR single nucleotide polymorphisms in non-small cell lung cancer patients and healthy individuals in the Republic of Serbia: a preliminary study
EP  - 10486
IS  - 8
SP  - 10479
VL  - 37
DO  - 10.1007/s13277-016-4930-4
ER  - 

@article{
author = "Obradović, Jasmina and Đorđević, Nataša and Tošić, Nataša and Mrdjanović, Jasminka and Stanković, Biljana and Stanić, Jelena and Zarić, Bojan and Perin, Branislav and Pavlović, Sonja and Jurisić, Vladimir",
year = "2016",
abstract = "The purpose of this study was to determine the frequencies of EGFR -216G  gt  T, -191C  gt  A, and 181946C  gt  T in Serbian non-small cell lung cancer (NSCLC) patients, as well as to compare it with healthy individuals, in order to assess their potential importance for lung cancer in Serbia. The study involved 56 NSCLC patients and 53 unrelated healthy volunteers, and genotyping was performed on DNA samples obtained from formalin-fixed paraffin-embedded lung tumor tissue and blood, respectively. This was the first time to show genotype frequencies of those single nucleotide polymorphisms for this study group from the territory of the Republic of Serbia. There was very strong evidence of association between age and death due to lung cancer (Pearson chi-square = 43.439, df = 2, p  lt  0,001), as well as between ever smoking and death due to lung cancer (Pearson chi-square = 31.727, df = 1, p  lt  0.001). When dominant genetic model (GG vs. GT+TT) was used for -216G  gt  T, we have found significant association (p = 0.012) between -216GG genotype and NSCLC patients within smokers' subgroup. So, carriers of -216GG genotype had higher risk (OR = 4.33, 95 % CI = 1.324-14.179) than noncarriers (GT and TT) for developing non-small cell lung cancer in our patients.",
publisher = "Sage Publications Ltd, London",
journal = "Tumor Biology",
title = "Frequencies of EGFR single nucleotide polymorphisms in non-small cell lung cancer patients and healthy individuals in the Republic of Serbia: a preliminary study",
pages = "10486-10479",
number = "8",
volume = "37",
doi = "10.1007/s13277-016-4930-4"
}

Obradović, J., Đorđević, N., Tošić, N., Mrdjanović, J., Stanković, B., Stanić, J., Zarić, B., Perin, B., Pavlović, S.,& Jurisić, V.. (2016). Frequencies of EGFR single nucleotide polymorphisms in non-small cell lung cancer patients and healthy individuals in the Republic of Serbia: a preliminary study. in Tumor Biology
Sage Publications Ltd, London., 37(8), 10479-10486.
https://doi.org/10.1007/s13277-016-4930-4

Obradović J, Đorđević N, Tošić N, Mrdjanović J, Stanković B, Stanić J, Zarić B, Perin B, Pavlović S, Jurisić V. Frequencies of EGFR single nucleotide polymorphisms in non-small cell lung cancer patients and healthy individuals in the Republic of Serbia: a preliminary study. in Tumor Biology. 2016;37(8):10479-10486.
doi:10.1007/s13277-016-4930-4 .

Obradović, Jasmina, Đorđević, Nataša, Tošić, Nataša, Mrdjanović, Jasminka, Stanković, Biljana, Stanić, Jelena, Zarić, Bojan, Perin, Branislav, Pavlović, Sonja, Jurisić, Vladimir, "Frequencies of EGFR single nucleotide polymorphisms in non-small cell lung cancer patients and healthy individuals in the Republic of Serbia: a preliminary study" in Tumor Biology, 37, no. 8 (2016):10479-10486,
https://doi.org/10.1007/s13277-016-4930-4 . .