TY  - JOUR
AU  - Đorđević, Ivana
AU  - Garai, Nemanja
AU  - Perić, Stojan
AU  - Karanović, Jelena
AU  - Pešović, Jovan
AU  - Brkusanin, Milos
AU  - Lavrnic, Dragana
AU  - Apostolski, Slobodan
AU  - Savić-Pavicević, Dusanka
AU  - Basta, Ivana
PY  - 2024
UR  - https://doi.org/10.1007/s12035-024-04183-8
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2346
AB  - Genome-wide association studies (GWAS) have provided strong evidence that early- and late-onset MG have different genetic backgrounds. Recent in silico analysis based on GWAS results revealed rs231735 and rs231770 variants within CTLA-4 locus as possible MG causative genetic factors. We aimed to explore the association of rs231735 and rs231770 with MG in a representative cohort of Serbian patients. We conducted an age-, sex-, and ethnicity-matched case–control study. Using TaqMan allele discrimination assays, the frequency of rs231735 and rs231770 genetic variants was examined in 447 AChR-MG patients and 447 matched controls. There was no significant association of rs231735 and rs231770 with the entire MG cohort (P > 0.05). Nevertheless, when stratifying patients into early-onset (n = 183) and late-onset MG (n = 264), we found early-onset patients had a significantly lower frequency of the rs231735 allele T compared to controls (OR = 0.734, 95% CI = 0.575–0.938, p10e6 permutation < 0.05), and rs231735 genotype TT and rs231770 genotype TT had a protective effect on early-onset MG (OR = 0.548, 95% CI = 0.339–0.888, and OR = 0.563, 95% CI = 0.314–1.011, p10e6 permutation < 0.05). Consequently, we found that individuals with the rs231735-rs231770 haplotype GC had a higher risk for developing early-onset MG (OR = 1.360, P = 0.027, p10e6 permutation < 0.05). Our results suggest that CTLA-4 rs231735 and rs231770 may be risk factors only for patients with early-onset MG in Serbian population.
PB  - Springer
T2  - Molecular Neurobiology
T2  - Molecular NeurobiologyMol Neurobiol
T1  - Association between Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4) Locus and Early-Onset Anti-acetylcholine Receptor-Positive Myasthenia Gravis in Serbian Patients
DO  - 10.1007/s12035-024-04183-8
ER  - 

@article{
author = "Đorđević, Ivana and Garai, Nemanja and Perić, Stojan and Karanović, Jelena and Pešović, Jovan and Brkusanin, Milos and Lavrnic, Dragana and Apostolski, Slobodan and Savić-Pavicević, Dusanka and Basta, Ivana",
year = "2024",
abstract = "Genome-wide association studies (GWAS) have provided strong evidence that early- and late-onset MG have different genetic backgrounds. Recent in silico analysis based on GWAS results revealed rs231735 and rs231770 variants within CTLA-4 locus as possible MG causative genetic factors. We aimed to explore the association of rs231735 and rs231770 with MG in a representative cohort of Serbian patients. We conducted an age-, sex-, and ethnicity-matched case–control study. Using TaqMan allele discrimination assays, the frequency of rs231735 and rs231770 genetic variants was examined in 447 AChR-MG patients and 447 matched controls. There was no significant association of rs231735 and rs231770 with the entire MG cohort (P > 0.05). Nevertheless, when stratifying patients into early-onset (n = 183) and late-onset MG (n = 264), we found early-onset patients had a significantly lower frequency of the rs231735 allele T compared to controls (OR = 0.734, 95% CI = 0.575–0.938, p10e6 permutation < 0.05), and rs231735 genotype TT and rs231770 genotype TT had a protective effect on early-onset MG (OR = 0.548, 95% CI = 0.339–0.888, and OR = 0.563, 95% CI = 0.314–1.011, p10e6 permutation < 0.05). Consequently, we found that individuals with the rs231735-rs231770 haplotype GC had a higher risk for developing early-onset MG (OR = 1.360, P = 0.027, p10e6 permutation < 0.05). Our results suggest that CTLA-4 rs231735 and rs231770 may be risk factors only for patients with early-onset MG in Serbian population.",
publisher = "Springer",
journal = "Molecular Neurobiology, Molecular NeurobiologyMol Neurobiol",
title = "Association between Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4) Locus and Early-Onset Anti-acetylcholine Receptor-Positive Myasthenia Gravis in Serbian Patients",
doi = "10.1007/s12035-024-04183-8"
}

Đorđević, I., Garai, N., Perić, S., Karanović, J., Pešović, J., Brkusanin, M., Lavrnic, D., Apostolski, S., Savić-Pavicević, D.,& Basta, I.. (2024). Association between Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4) Locus and Early-Onset Anti-acetylcholine Receptor-Positive Myasthenia Gravis in Serbian Patients. in Molecular Neurobiology
Springer..
https://doi.org/10.1007/s12035-024-04183-8

Đorđević I, Garai N, Perić S, Karanović J, Pešović J, Brkusanin M, Lavrnic D, Apostolski S, Savić-Pavicević D, Basta I. Association between Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4) Locus and Early-Onset Anti-acetylcholine Receptor-Positive Myasthenia Gravis in Serbian Patients. in Molecular Neurobiology. 2024;.
doi:10.1007/s12035-024-04183-8 .

Đorđević, Ivana, Garai, Nemanja, Perić, Stojan, Karanović, Jelena, Pešović, Jovan, Brkusanin, Milos, Lavrnic, Dragana, Apostolski, Slobodan, Savić-Pavicević, Dusanka, Basta, Ivana, "Association between Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4) Locus and Early-Onset Anti-acetylcholine Receptor-Positive Myasthenia Gravis in Serbian Patients" in Molecular Neurobiology (2024),
https://doi.org/10.1007/s12035-024-04183-8 . .