TY  - JOUR
AU  - Duarah, Rituparna
AU  - Aleksić, Ivana
AU  - Milivojević, Dušan
AU  - Rameshkumar, Saranya
AU  - Nikodinović-Runić, Jasmina
AU  - Padamati, Ramesh Babu
PY  - 2023
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2079
AB  - Novel bio-based, biodegradable packaging material was developed with multi-functional properties of good mechanical strength, potent biocompatibility, and antifungal attributes, predominantly against fungi vital in food spoilage. Biodegradable polymer composites were prepared with a natural antifungal agent, nystatin (Nyst), by melt processing technique for the first time. Initially, Polycaprolactone (PCL) was melt-mixed with various percentages of nystatin to produce nystatin-encapsulated PCL composites (PCL/Nyst). The as-prepared PCL/Nyst composites were melt-mixed with polylactic acid (PLA) to produce nystatin PLA/PCL blend composites. Subsequently, the prepared composites were compression molded in the form of films (1 mm) for further characterization. The composite's structural properties were evaluated by SEM, FTIR, mechanical and thermal studies. In addition, the composites were tested in vitro against a panel of pathogenic fungi and for antibiofilm attributes, specifically against three Candida species (C. albicans ATCC10231, C. parapsilosis ATCC22019, and C. glabrata ATCC2001), and foodborne Penicillium sp. All the composites containing 2 to 20 wt% nystatin displayed good activity and sustained nystatin release for up to 4 days. Thus, the overall study demonstrates the potential application of natural antifungal agents in biodegradable polymers to produce novel composite films for antimicrobial packaging without inducing any toxicity, judged from the toxicity assay using nematode Caenorhabditis elegans.
PB  - Wiley
T2  - Journal of Applied Polymer Science
T1  - Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach
SP  - e54663
DO  - 10.1002/app.54663
ER  - 

@article{
author = "Duarah, Rituparna and Aleksić, Ivana and Milivojević, Dušan and Rameshkumar, Saranya and Nikodinović-Runić, Jasmina and Padamati, Ramesh Babu",
year = "2023",
abstract = "Novel bio-based, biodegradable packaging material was developed with multi-functional properties of good mechanical strength, potent biocompatibility, and antifungal attributes, predominantly against fungi vital in food spoilage. Biodegradable polymer composites were prepared with a natural antifungal agent, nystatin (Nyst), by melt processing technique for the first time. Initially, Polycaprolactone (PCL) was melt-mixed with various percentages of nystatin to produce nystatin-encapsulated PCL composites (PCL/Nyst). The as-prepared PCL/Nyst composites were melt-mixed with polylactic acid (PLA) to produce nystatin PLA/PCL blend composites. Subsequently, the prepared composites were compression molded in the form of films (1 mm) for further characterization. The composite's structural properties were evaluated by SEM, FTIR, mechanical and thermal studies. In addition, the composites were tested in vitro against a panel of pathogenic fungi and for antibiofilm attributes, specifically against three Candida species (C. albicans ATCC10231, C. parapsilosis ATCC22019, and C. glabrata ATCC2001), and foodborne Penicillium sp. All the composites containing 2 to 20 wt% nystatin displayed good activity and sustained nystatin release for up to 4 days. Thus, the overall study demonstrates the potential application of natural antifungal agents in biodegradable polymers to produce novel composite films for antimicrobial packaging without inducing any toxicity, judged from the toxicity assay using nematode Caenorhabditis elegans.",
publisher = "Wiley",
journal = "Journal of Applied Polymer Science",
title = "Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach",
pages = "e54663",
doi = "10.1002/app.54663"
}

Duarah, R., Aleksić, I., Milivojević, D., Rameshkumar, S., Nikodinović-Runić, J.,& Padamati, R. B.. (2023). Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach. in Journal of Applied Polymer Science
Wiley., e54663.
https://doi.org/10.1002/app.54663

Duarah R, Aleksić I, Milivojević D, Rameshkumar S, Nikodinović-Runić J, Padamati RB. Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach. in Journal of Applied Polymer Science. 2023;:e54663.
doi:10.1002/app.54663 .

Duarah, Rituparna, Aleksić, Ivana, Milivojević, Dušan, Rameshkumar, Saranya, Nikodinović-Runić, Jasmina, Padamati, Ramesh Babu, "Development of nystatin-based antifungal, biodegradable polymer composite materials for food packaging via. melt processing approach" in Journal of Applied Polymer Science (2023):e54663,
https://doi.org/10.1002/app.54663 . .