TY  - JOUR
AU  - Gazouli, Maria
AU  - Wouters, Mira M.
AU  - Kapur-Pojskić, Lejla
AU  - Bengtson, May-Bente
AU  - Friedman, Eitan
AU  - Nikčević, Gordana
AU  - Demetriou, Christiana A.
AU  - Mulak, Agata
AU  - Santos, Javier
AU  - Niesler, Beate
PY  - 2016
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/977
AB  - IBS is the most prevalent functional gastrointestinal disorder and phenotypically characterized by chronic abdominal discomfort, pain and altered defecation patterns. The pathophysiology of IBS is multifactorial, albeit with a substantial genetic component. To date, studies using various methodologies, ranging from family and twin studies to candidate gene approaches and genome-wide association studies, have identified several genetic variants in the context of IBS. Yet, despite enlarged sample sizes, increased statistical power and meta-analyses in the past 7 years, positive associations are still scarce and/or have not been reproduced. In addition, epigenetic and pharmacogenetic approaches remain in their infancy. A major hurdle is the lack of large homogenized case-control cohorts recruited according to standardized and harmonized criteria. The COST Action BM1106 GENIEUR (GENes in Irritable Bowel Syndrome Research Network EURope) has been established to address these obstacles. In this Review, the (epi)genetic working group of GENIEUR reports on the current state-of-the-art in the field, highlights fundamental flaws and pitfalls in current IBS (epi) genetic research and provides a vision on how to address and improve (epi) genetic approaches in this complex disorder in the future.
PB  - Nature Portfolio, Berlin
T2  - Nature Reviews Gastroenterology & Hepatology
T1  - Lessons learned - resolving the enigma of genetic factors in IBS
EP  - 87
IS  - 2
SP  - 77
VL  - 13
DO  - 10.1038/nrgastro.2015.206
ER  - 

@article{
author = "Gazouli, Maria and Wouters, Mira M. and Kapur-Pojskić, Lejla and Bengtson, May-Bente and Friedman, Eitan and Nikčević, Gordana and Demetriou, Christiana A. and Mulak, Agata and Santos, Javier and Niesler, Beate",
year = "2016",
abstract = "IBS is the most prevalent functional gastrointestinal disorder and phenotypically characterized by chronic abdominal discomfort, pain and altered defecation patterns. The pathophysiology of IBS is multifactorial, albeit with a substantial genetic component. To date, studies using various methodologies, ranging from family and twin studies to candidate gene approaches and genome-wide association studies, have identified several genetic variants in the context of IBS. Yet, despite enlarged sample sizes, increased statistical power and meta-analyses in the past 7 years, positive associations are still scarce and/or have not been reproduced. In addition, epigenetic and pharmacogenetic approaches remain in their infancy. A major hurdle is the lack of large homogenized case-control cohorts recruited according to standardized and harmonized criteria. The COST Action BM1106 GENIEUR (GENes in Irritable Bowel Syndrome Research Network EURope) has been established to address these obstacles. In this Review, the (epi)genetic working group of GENIEUR reports on the current state-of-the-art in the field, highlights fundamental flaws and pitfalls in current IBS (epi) genetic research and provides a vision on how to address and improve (epi) genetic approaches in this complex disorder in the future.",
publisher = "Nature Portfolio, Berlin",
journal = "Nature Reviews Gastroenterology & Hepatology",
title = "Lessons learned - resolving the enigma of genetic factors in IBS",
pages = "87-77",
number = "2",
volume = "13",
doi = "10.1038/nrgastro.2015.206"
}

Gazouli, M., Wouters, M. M., Kapur-Pojskić, L., Bengtson, M., Friedman, E., Nikčević, G., Demetriou, C. A., Mulak, A., Santos, J.,& Niesler, B.. (2016). Lessons learned - resolving the enigma of genetic factors in IBS. in Nature Reviews Gastroenterology & Hepatology
Nature Portfolio, Berlin., 13(2), 77-87.
https://doi.org/10.1038/nrgastro.2015.206

Gazouli M, Wouters MM, Kapur-Pojskić L, Bengtson M, Friedman E, Nikčević G, Demetriou CA, Mulak A, Santos J, Niesler B. Lessons learned - resolving the enigma of genetic factors in IBS. in Nature Reviews Gastroenterology & Hepatology. 2016;13(2):77-87.
doi:10.1038/nrgastro.2015.206 .

Gazouli, Maria, Wouters, Mira M., Kapur-Pojskić, Lejla, Bengtson, May-Bente, Friedman, Eitan, Nikčević, Gordana, Demetriou, Christiana A., Mulak, Agata, Santos, Javier, Niesler, Beate, "Lessons learned - resolving the enigma of genetic factors in IBS" in Nature Reviews Gastroenterology & Hepatology, 13, no. 2 (2016):77-87,
https://doi.org/10.1038/nrgastro.2015.206 . .

TY  - JOUR
AU  - Gazouli, Maria
AU  - Wouters, Mira M.
AU  - Kapur-Pojskić, Lejla
AU  - Bengtson, May-Bente
AU  - Friedman, Eitan
AU  - Nikčević, Gordana
AU  - Demetriou, Christiana A.
AU  - Mulak, Agata
AU  - Santos, Javier
AU  - Niesler, Beate
PY  - 2016
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1625
AB  - IBS is the most prevalent functional gastrointestinal disorder and phenotypically characterized by chronic abdominal discomfort, pain and altered defecation patterns. The pathophysiology of IBS is multifactorial, albeit with a substantial genetic component. To date, studies using various methodologies, ranging from family and twin studies to candidate gene approaches and genome-wide association studies, have identified several genetic variants in the context of IBS. Yet, despite enlarged sample sizes, increased statistical power and meta-analyses in the past 7 years, positive associations are still scarce and/or have not been reproduced. In addition, epigenetic and pharmacogenetic approaches remain in their infancy. A major hurdle is the lack of large homogenized case-control cohorts recruited according to standardized and harmonized criteria. The COST Action BM1106 GENIEUR (GENes in Irritable Bowel Syndrome Research Network EURope) has been established to address these obstacles. In this Review, the (epi)genetic working group of GENIEUR reports on the current state-of-the-art in the field, highlights fundamental flaws and pitfalls in current IBS (epi) genetic research and provides a vision on how to address and improve (epi) genetic approaches in this complex disorder in the future.
PB  - Nature Portfolio, Berlin
T2  - Nature Reviews Gastroenterology & Hepatology
T1  - Lessons learned - resolving the enigma of genetic factors in IBS
EP  - 87
IS  - 2
SP  - 77
VL  - 13
DO  - 10.1038/nrgastro.2015.206
ER  - 

@article{
author = "Gazouli, Maria and Wouters, Mira M. and Kapur-Pojskić, Lejla and Bengtson, May-Bente and Friedman, Eitan and Nikčević, Gordana and Demetriou, Christiana A. and Mulak, Agata and Santos, Javier and Niesler, Beate",
year = "2016",
abstract = "IBS is the most prevalent functional gastrointestinal disorder and phenotypically characterized by chronic abdominal discomfort, pain and altered defecation patterns. The pathophysiology of IBS is multifactorial, albeit with a substantial genetic component. To date, studies using various methodologies, ranging from family and twin studies to candidate gene approaches and genome-wide association studies, have identified several genetic variants in the context of IBS. Yet, despite enlarged sample sizes, increased statistical power and meta-analyses in the past 7 years, positive associations are still scarce and/or have not been reproduced. In addition, epigenetic and pharmacogenetic approaches remain in their infancy. A major hurdle is the lack of large homogenized case-control cohorts recruited according to standardized and harmonized criteria. The COST Action BM1106 GENIEUR (GENes in Irritable Bowel Syndrome Research Network EURope) has been established to address these obstacles. In this Review, the (epi)genetic working group of GENIEUR reports on the current state-of-the-art in the field, highlights fundamental flaws and pitfalls in current IBS (epi) genetic research and provides a vision on how to address and improve (epi) genetic approaches in this complex disorder in the future.",
publisher = "Nature Portfolio, Berlin",
journal = "Nature Reviews Gastroenterology & Hepatology",
title = "Lessons learned - resolving the enigma of genetic factors in IBS",
pages = "87-77",
number = "2",
volume = "13",
doi = "10.1038/nrgastro.2015.206"
}

Gazouli, M., Wouters, M. M., Kapur-Pojskić, L., Bengtson, M., Friedman, E., Nikčević, G., Demetriou, C. A., Mulak, A., Santos, J.,& Niesler, B.. (2016). Lessons learned - resolving the enigma of genetic factors in IBS. in Nature Reviews Gastroenterology & Hepatology
Nature Portfolio, Berlin., 13(2), 77-87.
https://doi.org/10.1038/nrgastro.2015.206

Gazouli M, Wouters MM, Kapur-Pojskić L, Bengtson M, Friedman E, Nikčević G, Demetriou CA, Mulak A, Santos J, Niesler B. Lessons learned - resolving the enigma of genetic factors in IBS. in Nature Reviews Gastroenterology & Hepatology. 2016;13(2):77-87.
doi:10.1038/nrgastro.2015.206 .

Gazouli, Maria, Wouters, Mira M., Kapur-Pojskić, Lejla, Bengtson, May-Bente, Friedman, Eitan, Nikčević, Gordana, Demetriou, Christiana A., Mulak, Agata, Santos, Javier, Niesler, Beate, "Lessons learned - resolving the enigma of genetic factors in IBS" in Nature Reviews Gastroenterology & Hepatology, 13, no. 2 (2016):77-87,
https://doi.org/10.1038/nrgastro.2015.206 . .