TY  - JOUR
AU  - Dinić, Miroslav
AU  - Herholz, Marija
AU  - Kacarević, Uros
AU  - Radojević, Dušan
AU  - Novović, Katarina
AU  - Đokić, Jelena
AU  - Trifunović, Aleksandra
AU  - Golić, Nataša
PY  - 2021
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1431
AB  - Gut homeostasis is maintained by the close interaction between commensal intestinal microbiota and the host, affecting the most complex physiological processes, such as aging. Some commensal bacteria with the potential to promote healthy aging arise as attractive candidates for the development of pro-longevity probiotics. Here, we showed that heat-inactivated human commensal Lactobacillus fermentum BGHV110 (BGHV110) extends the lifespan of Caenorhabditis elegans and improves age-related physiological features, including locomotor function and lipid metabolism. Mechanistically, we found that BGHV110 promotes HLH30/TFEB-dependent autophagy to delay aging, as longevity assurance was completely abolished in the mutant lacking HLH-30, a major autophagy regulator in C. elegans. Moreover, we observed that BGHV110 partially decreased the content of lipid droplets in an HLH-30-dependent manner and, at the same time, slightly increased mitochondrial activity. In summary, this study demonstrates that specific factors from commensal bacteria can be used to exploit HLH-30/TFEB-mediated autophagy in order to promote longevity and fitness of the host.
PB  - Impact Journals LLC
T2  - Aging
T1  - Host-commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy
EP  - 8054
IS  - 6
SP  - 8040
VL  - 13
DO  - 10.18632/aging.202885
ER  - 

@article{
author = "Dinić, Miroslav and Herholz, Marija and Kacarević, Uros and Radojević, Dušan and Novović, Katarina and Đokić, Jelena and Trifunović, Aleksandra and Golić, Nataša",
year = "2021",
abstract = "Gut homeostasis is maintained by the close interaction between commensal intestinal microbiota and the host, affecting the most complex physiological processes, such as aging. Some commensal bacteria with the potential to promote healthy aging arise as attractive candidates for the development of pro-longevity probiotics. Here, we showed that heat-inactivated human commensal Lactobacillus fermentum BGHV110 (BGHV110) extends the lifespan of Caenorhabditis elegans and improves age-related physiological features, including locomotor function and lipid metabolism. Mechanistically, we found that BGHV110 promotes HLH30/TFEB-dependent autophagy to delay aging, as longevity assurance was completely abolished in the mutant lacking HLH-30, a major autophagy regulator in C. elegans. Moreover, we observed that BGHV110 partially decreased the content of lipid droplets in an HLH-30-dependent manner and, at the same time, slightly increased mitochondrial activity. In summary, this study demonstrates that specific factors from commensal bacteria can be used to exploit HLH-30/TFEB-mediated autophagy in order to promote longevity and fitness of the host.",
publisher = "Impact Journals LLC",
journal = "Aging",
title = "Host-commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy",
pages = "8054-8040",
number = "6",
volume = "13",
doi = "10.18632/aging.202885"
}

Dinić, M., Herholz, M., Kacarević, U., Radojević, D., Novović, K., Đokić, J., Trifunović, A.,& Golić, N.. (2021). Host-commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy. in Aging
Impact Journals LLC., 13(6), 8040-8054.
https://doi.org/10.18632/aging.202885

Dinić M, Herholz M, Kacarević U, Radojević D, Novović K, Đokić J, Trifunović A, Golić N. Host-commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy. in Aging. 2021;13(6):8040-8054.
doi:10.18632/aging.202885 .

Dinić, Miroslav, Herholz, Marija, Kacarević, Uros, Radojević, Dušan, Novović, Katarina, Đokić, Jelena, Trifunović, Aleksandra, Golić, Nataša, "Host-commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy" in Aging, 13, no. 6 (2021):8040-8054,
https://doi.org/10.18632/aging.202885 . .