TY  - JOUR
AU  - Talty, Aaron
AU  - Deegan, Shane
AU  - Ljujić, Mila
AU  - Mnich, Katarzyna
AU  - Naicker, Serika D.
AU  - Quandt, Dagmar
AU  - Zeng, Qingping
AU  - Patterson, John B.
AU  - Gorman, Adrienne M.
AU  - Griffin, Matthew D.
AU  - Samali, Afshin
AU  - Logue, Susan E.
PY  - 2020
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1379
PB  - Nature Publishing Group, London
T2  - Cell Death & Disease
T1  - Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta (vol 77, pg 568, 2019)
IS  - 1
VL  - 11
DO  - 10.1038/s41419-019-2189-6
ER  - 

@article{
author = "Talty, Aaron and Deegan, Shane and Ljujić, Mila and Mnich, Katarzyna and Naicker, Serika D. and Quandt, Dagmar and Zeng, Qingping and Patterson, John B. and Gorman, Adrienne M. and Griffin, Matthew D. and Samali, Afshin and Logue, Susan E.",
year = "2020",
publisher = "Nature Publishing Group, London",
journal = "Cell Death & Disease",
title = "Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta (vol 77, pg 568, 2019)",
number = "1",
volume = "11",
doi = "10.1038/s41419-019-2189-6"
}

Talty, A., Deegan, S., Ljujić, M., Mnich, K., Naicker, S. D., Quandt, D., Zeng, Q., Patterson, J. B., Gorman, A. M., Griffin, M. D., Samali, A.,& Logue, S. E.. (2020). Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta (vol 77, pg 568, 2019). in Cell Death & Disease
Nature Publishing Group, London., 11(1).
https://doi.org/10.1038/s41419-019-2189-6

Talty A, Deegan S, Ljujić M, Mnich K, Naicker SD, Quandt D, Zeng Q, Patterson JB, Gorman AM, Griffin MD, Samali A, Logue SE. Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta (vol 77, pg 568, 2019). in Cell Death & Disease. 2020;11(1).
doi:10.1038/s41419-019-2189-6 .

Talty, Aaron, Deegan, Shane, Ljujić, Mila, Mnich, Katarzyna, Naicker, Serika D., Quandt, Dagmar, Zeng, Qingping, Patterson, John B., Gorman, Adrienne M., Griffin, Matthew D., Samali, Afshin, Logue, Susan E., "Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta (vol 77, pg 568, 2019)" in Cell Death & Disease, 11, no. 1 (2020),
https://doi.org/10.1038/s41419-019-2189-6 . .

TY  - JOUR
AU  - Talty, Aaron
AU  - Deegan, Shane
AU  - Ljujić, Mila
AU  - Mnich, Katarzyna
AU  - Naicker, Serika D.
AU  - Quandt, Dagmar
AU  - Zeng, Qingping
AU  - Patterson, John B.
AU  - Gorman, Adrienne M.
AU  - Griffin, Matthew D.
AU  - Samali, Afshin
AU  - Logue, Susan E.
PY  - 2019
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1201
AB  - The inflammasome is a multiprotein complex assembled in response to Pathogen Associated Molecular Patterns (PAMPs) and Danger Associated Molecular Patterns (DAMPS). Inflammasome activation occurs through a two-step mechanism, with the first signal facilitating priming of inflammasome components while the second signal triggers complex assembly. Once assembled, the inflammasome recruits and activates pro-caspase-1, which in turn processes pro-interleukin (IL)-18 and pro-IL-1 beta into their bio-active forms. Owing to its key role in the regulation of innate immune responses, the inflammasome has emerged as a therapeutic target for the treatment of inflammatory conditions. In this study we demonstrate that IRE1 alpha, a key component of the Unfolded Protein Response, contributes to assembly of the NLRP3 inflammasome. Blockade of IRE1 alpha RNase signaling lowered NLRP3 inflammasome assembly, caspase-1 activation and pro-IL-1 beta processing. These results underscore both the importance and potential therapeutic relevance of targeting IRE1 alpha signaling in conditions of excessive inflammasome formation.
PB  - Nature Publishing Group, London
T2  - Cell Death & Disease
T1  - Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta
VL  - 10
DO  - 10.1038/s41419-019-1847-z
ER  - 

@article{
author = "Talty, Aaron and Deegan, Shane and Ljujić, Mila and Mnich, Katarzyna and Naicker, Serika D. and Quandt, Dagmar and Zeng, Qingping and Patterson, John B. and Gorman, Adrienne M. and Griffin, Matthew D. and Samali, Afshin and Logue, Susan E.",
year = "2019",
abstract = "The inflammasome is a multiprotein complex assembled in response to Pathogen Associated Molecular Patterns (PAMPs) and Danger Associated Molecular Patterns (DAMPS). Inflammasome activation occurs through a two-step mechanism, with the first signal facilitating priming of inflammasome components while the second signal triggers complex assembly. Once assembled, the inflammasome recruits and activates pro-caspase-1, which in turn processes pro-interleukin (IL)-18 and pro-IL-1 beta into their bio-active forms. Owing to its key role in the regulation of innate immune responses, the inflammasome has emerged as a therapeutic target for the treatment of inflammatory conditions. In this study we demonstrate that IRE1 alpha, a key component of the Unfolded Protein Response, contributes to assembly of the NLRP3 inflammasome. Blockade of IRE1 alpha RNase signaling lowered NLRP3 inflammasome assembly, caspase-1 activation and pro-IL-1 beta processing. These results underscore both the importance and potential therapeutic relevance of targeting IRE1 alpha signaling in conditions of excessive inflammasome formation.",
publisher = "Nature Publishing Group, London",
journal = "Cell Death & Disease",
title = "Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta",
volume = "10",
doi = "10.1038/s41419-019-1847-z"
}

Talty, A., Deegan, S., Ljujić, M., Mnich, K., Naicker, S. D., Quandt, D., Zeng, Q., Patterson, J. B., Gorman, A. M., Griffin, M. D., Samali, A.,& Logue, S. E.. (2019). Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta. in Cell Death & Disease
Nature Publishing Group, London., 10.
https://doi.org/10.1038/s41419-019-1847-z

Talty A, Deegan S, Ljujić M, Mnich K, Naicker SD, Quandt D, Zeng Q, Patterson JB, Gorman AM, Griffin MD, Samali A, Logue SE. Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta. in Cell Death & Disease. 2019;10.
doi:10.1038/s41419-019-1847-z .

Talty, Aaron, Deegan, Shane, Ljujić, Mila, Mnich, Katarzyna, Naicker, Serika D., Quandt, Dagmar, Zeng, Qingping, Patterson, John B., Gorman, Adrienne M., Griffin, Matthew D., Samali, Afshin, Logue, Susan E., "Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta" in Cell Death & Disease, 10 (2019),
https://doi.org/10.1038/s41419-019-1847-z . .