TY  - JOUR
AU  - Dimić, Dusan S.
AU  - Marković, Zoran S.
AU  - Saso, Luciano
AU  - Avdović, Edina H.
AU  - Dorović, Jelena R.
AU  - Petrović, Isidora
AU  - Stanisavljević Ninković, Danijela
AU  - Stevanović, Milena
AU  - Potocnak, Ivan
AU  - Samol'ova, Erika
AU  - Trifunović, Srecko R.
AU  - Marković, Jasmina M. Dimitric
PY  - 2019
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1295
AB  - The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyDamino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography. It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure. The compound was tested in vitro against different cell lines, healthy human keratinocyte HaCaT, cervical squamous cell carcinoma SiHa, breast carcinoma MCF7, and hepatocellular carcinoma HepG2. Compared to control, the new derivate showed a stronger effect on both healthy and carcinoma cell lines, with the most prominent effect on the breast carcinoma MCF7 cell line. The molecular docking study, obtained for ten different conformations of the new compound, showed its inhibitory nature against CDKS protein. Lower inhibition constant, relative to one of 4-OH-coumarine, proved stronger and more numerous interactions with CDKS protein. These interactions were carefully examined for both parent molecule and derivative and explained from a structural point of view.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine and Cellular Longevity
T1  - Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent
VL  - 2019
DO  - 10.1155/2019/2069250
ER  - 

@article{
author = "Dimić, Dusan S. and Marković, Zoran S. and Saso, Luciano and Avdović, Edina H. and Dorović, Jelena R. and Petrović, Isidora and Stanisavljević Ninković, Danijela and Stevanović, Milena and Potocnak, Ivan and Samol'ova, Erika and Trifunović, Srecko R. and Marković, Jasmina M. Dimitric",
year = "2019",
abstract = "The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyDamino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography. It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure. The compound was tested in vitro against different cell lines, healthy human keratinocyte HaCaT, cervical squamous cell carcinoma SiHa, breast carcinoma MCF7, and hepatocellular carcinoma HepG2. Compared to control, the new derivate showed a stronger effect on both healthy and carcinoma cell lines, with the most prominent effect on the breast carcinoma MCF7 cell line. The molecular docking study, obtained for ten different conformations of the new compound, showed its inhibitory nature against CDKS protein. Lower inhibition constant, relative to one of 4-OH-coumarine, proved stronger and more numerous interactions with CDKS protein. These interactions were carefully examined for both parent molecule and derivative and explained from a structural point of view.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent",
volume = "2019",
doi = "10.1155/2019/2069250"
}

Dimić, D. S., Marković, Z. S., Saso, L., Avdović, E. H., Dorović, J. R., Petrović, I., Stanisavljević Ninković, D., Stevanović, M., Potocnak, I., Samol'ova, E., Trifunović, S. R.,& Marković, J. M. D.. (2019). Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. in Oxidative Medicine and Cellular Longevity
Hindawi Ltd, London., 2019.
https://doi.org/10.1155/2019/2069250

Dimić DS, Marković ZS, Saso L, Avdović EH, Dorović JR, Petrović I, Stanisavljević Ninković D, Stevanović M, Potocnak I, Samol'ova E, Trifunović SR, Marković JMD. Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. in Oxidative Medicine and Cellular Longevity. 2019;2019.
doi:10.1155/2019/2069250 .

Dimić, Dusan S., Marković, Zoran S., Saso, Luciano, Avdović, Edina H., Dorović, Jelena R., Petrović, Isidora, Stanisavljević Ninković, Danijela, Stevanović, Milena, Potocnak, Ivan, Samol'ova, Erika, Trifunović, Srecko R., Marković, Jasmina M. Dimitric, "Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent" in Oxidative Medicine and Cellular Longevity, 2019 (2019),
https://doi.org/10.1155/2019/2069250 . .