TY  - JOUR
AU  - Buha, I.
AU  - Škodrić-Trifunović, V.
AU  - Anđelković, Marina
AU  - Pavlović, Sonja
AU  - Vreća, M.
AU  - Stjepanović, M.
AU  - Milin-Lazović, Jelena
AU  - Simić, M.
AU  - Antonijević, G.
AU  - Spasovski, Vesna
PY  - 2022
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1542
AB  - Introduction: Tuberculosis (TB) continues to be a significant public health problem. The role of small non-coding RNAs, such as microRNAs (miRNAs), was investigated extensively in Mycobacterium tuberculosis (MTB) infection as well as in a variety of other pathophysiological processes in recent years. It was found that miRNAs act as regulators of both early reaction to MTB infection and in process of adaptation of the host immune cells during latent course of the disease. Molecule miRNA-146a is expressed exclusively in immune cells and it has the most prominent role in modulation of innate immunity. Methodology: We investigated the level of expression of miRNA-146a using an RT-qPCR technique in peripheral blood mononuclear cells of 44 patients with active pulmonary TB and 17 healthy individuals. We also analyzed the significance of miRNA-146a rs2910164 SNV for expression profile of miRNA-146a, in order to investigate potential usage of miRNA-146a as a biomarker for TB. Results: There was statistically significant decrease of expression of miRNA-146a in TB group compared to control group. When gender cohorts were analyzed, the expression levels in TB male and TB female subgroup were significantly lower than the expression levels in the same gender control subgroups. Conclusions: Our results indicate that miRNA-146a plays a significant role in the pathogenesis of TB, suggesting that miRNA-146a could be used as a biomarker for active pulmonary TB.
PB  - Journal of Infection in Developing Countries
T2  - Journal of Infection in Developing Countries
T1  - Association between active pulmonary tuberculosis and miRNA-146a: A preliminary study from Serbia
EP  - 1332
IS  - 8
SP  - 1317
VL  - 16
DO  - 10.3855/jidc.16721
ER  - 

@article{
author = "Buha, I. and Škodrić-Trifunović, V. and Anđelković, Marina and Pavlović, Sonja and Vreća, M. and Stjepanović, M. and Milin-Lazović, Jelena and Simić, M. and Antonijević, G. and Spasovski, Vesna",
year = "2022",
abstract = "Introduction: Tuberculosis (TB) continues to be a significant public health problem. The role of small non-coding RNAs, such as microRNAs (miRNAs), was investigated extensively in Mycobacterium tuberculosis (MTB) infection as well as in a variety of other pathophysiological processes in recent years. It was found that miRNAs act as regulators of both early reaction to MTB infection and in process of adaptation of the host immune cells during latent course of the disease. Molecule miRNA-146a is expressed exclusively in immune cells and it has the most prominent role in modulation of innate immunity. Methodology: We investigated the level of expression of miRNA-146a using an RT-qPCR technique in peripheral blood mononuclear cells of 44 patients with active pulmonary TB and 17 healthy individuals. We also analyzed the significance of miRNA-146a rs2910164 SNV for expression profile of miRNA-146a, in order to investigate potential usage of miRNA-146a as a biomarker for TB. Results: There was statistically significant decrease of expression of miRNA-146a in TB group compared to control group. When gender cohorts were analyzed, the expression levels in TB male and TB female subgroup were significantly lower than the expression levels in the same gender control subgroups. Conclusions: Our results indicate that miRNA-146a plays a significant role in the pathogenesis of TB, suggesting that miRNA-146a could be used as a biomarker for active pulmonary TB.",
publisher = "Journal of Infection in Developing Countries",
journal = "Journal of Infection in Developing Countries",
title = "Association between active pulmonary tuberculosis and miRNA-146a: A preliminary study from Serbia",
pages = "1332-1317",
number = "8",
volume = "16",
doi = "10.3855/jidc.16721"
}

Buha, I., Škodrić-Trifunović, V., Anđelković, M., Pavlović, S., Vreća, M., Stjepanović, M., Milin-Lazović, J., Simić, M., Antonijević, G.,& Spasovski, V.. (2022). Association between active pulmonary tuberculosis and miRNA-146a: A preliminary study from Serbia. in Journal of Infection in Developing Countries
Journal of Infection in Developing Countries., 16(8), 1317-1332.
https://doi.org/10.3855/jidc.16721

Buha I, Škodrić-Trifunović V, Anđelković M, Pavlović S, Vreća M, Stjepanović M, Milin-Lazović J, Simić M, Antonijević G, Spasovski V. Association between active pulmonary tuberculosis and miRNA-146a: A preliminary study from Serbia. in Journal of Infection in Developing Countries. 2022;16(8):1317-1332.
doi:10.3855/jidc.16721 .

Buha, I., Škodrić-Trifunović, V., Anđelković, Marina, Pavlović, Sonja, Vreća, M., Stjepanović, M., Milin-Lazović, Jelena, Simić, M., Antonijević, G., Spasovski, Vesna, "Association between active pulmonary tuberculosis and miRNA-146a: A preliminary study from Serbia" in Journal of Infection in Developing Countries, 16, no. 8 (2022):1317-1332,
https://doi.org/10.3855/jidc.16721 . .