TY  - JOUR
AU  - Huvet, M.
AU  - Toni, T.
AU  - Sheng, X.
AU  - Thorne, T.
AU  - Jovanović, Goran
AU  - Engl, C.
AU  - Buck, M.
AU  - Pinney, J. W.
AU  - Stumpf, M. P. H.
PY  - 2011
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/483
AB  - Here, we use a systematic analysis of the genes that make up and regulate the Psp system in E. coli in order to elucidate the evolutionary history of the system. We compare gene sharing, sequence evolution, and conservation of protein-coding as well as noncoding DNA sequences and link these to comparative analyses of genome/operon organization across 698 bacterial genomes. Finally, we evaluate experimentally the biological advantage/disadvantage of a simplified version of the Psp system under different oxygen-related environments. Our results suggest that the Psp system evolved around a core response mechanism by gradually co-opting genes into the system to provide more nuanced sensory, signaling, and effector functionalities. We find that recruitment of new genes into the response machinery is closely linked to incorporation of these genes into a psp operon as is seen in E. coli, which contains the bulk of genes involved in the response. The organization of this operon allows for surprising levels of additional transcriptional control and flexibility. The results discussed here suggest that the components of such signaling systems will only be evolutionarily conserved if the overall functionality of the system can be maintained.
PB  - Oxford Univ Press, Oxford
T2  - Molecular Biology and Evolution
T1  - The Evolution of the Phage Shock Protein Response System: Interplay between Protein Function, Genomic Organization, and System Function
EP  - 1155
IS  - 3
SP  - 1141
VL  - 28
DO  - 10.1093/molbev/msq301
ER  - 

@article{
author = "Huvet, M. and Toni, T. and Sheng, X. and Thorne, T. and Jovanović, Goran and Engl, C. and Buck, M. and Pinney, J. W. and Stumpf, M. P. H.",
year = "2011",
abstract = "Here, we use a systematic analysis of the genes that make up and regulate the Psp system in E. coli in order to elucidate the evolutionary history of the system. We compare gene sharing, sequence evolution, and conservation of protein-coding as well as noncoding DNA sequences and link these to comparative analyses of genome/operon organization across 698 bacterial genomes. Finally, we evaluate experimentally the biological advantage/disadvantage of a simplified version of the Psp system under different oxygen-related environments. Our results suggest that the Psp system evolved around a core response mechanism by gradually co-opting genes into the system to provide more nuanced sensory, signaling, and effector functionalities. We find that recruitment of new genes into the response machinery is closely linked to incorporation of these genes into a psp operon as is seen in E. coli, which contains the bulk of genes involved in the response. The organization of this operon allows for surprising levels of additional transcriptional control and flexibility. The results discussed here suggest that the components of such signaling systems will only be evolutionarily conserved if the overall functionality of the system can be maintained.",
publisher = "Oxford Univ Press, Oxford",
journal = "Molecular Biology and Evolution",
title = "The Evolution of the Phage Shock Protein Response System: Interplay between Protein Function, Genomic Organization, and System Function",
pages = "1155-1141",
number = "3",
volume = "28",
doi = "10.1093/molbev/msq301"
}

Huvet, M., Toni, T., Sheng, X., Thorne, T., Jovanović, G., Engl, C., Buck, M., Pinney, J. W.,& Stumpf, M. P. H.. (2011). The Evolution of the Phage Shock Protein Response System: Interplay between Protein Function, Genomic Organization, and System Function. in Molecular Biology and Evolution
Oxford Univ Press, Oxford., 28(3), 1141-1155.
https://doi.org/10.1093/molbev/msq301

Huvet M, Toni T, Sheng X, Thorne T, Jovanović G, Engl C, Buck M, Pinney JW, Stumpf MPH. The Evolution of the Phage Shock Protein Response System: Interplay between Protein Function, Genomic Organization, and System Function. in Molecular Biology and Evolution. 2011;28(3):1141-1155.
doi:10.1093/molbev/msq301 .

Huvet, M., Toni, T., Sheng, X., Thorne, T., Jovanović, Goran, Engl, C., Buck, M., Pinney, J. W., Stumpf, M. P. H., "The Evolution of the Phage Shock Protein Response System: Interplay between Protein Function, Genomic Organization, and System Function" in Molecular Biology and Evolution, 28, no. 3 (2011):1141-1155,
https://doi.org/10.1093/molbev/msq301 . .