TY  - JOUR
AU  - Đedović, Neda
AU  - Jevtić, Bojan
AU  - Jose Mansilla, M.
AU  - Petković, Filip
AU  - Blazevski, Jana
AU  - Timotijević, Gordana
AU  - Navarro-Barriuso, Juan
AU  - Martinez-Caceres, Eva
AU  - Mostarica Stojkovide, Marija
AU  - Miljković, Đorđe
PY  - 2019
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1252
AB  - Dendritic cells (DC) are responsible for the initiation and shaping of the adaptive immune response and are in the focus of autoimmunity research. We were interested in comparison of DC obtained from autoimmunity-prone Dark Agouti (DA) rats and autoimmunity-resistant Albino Oxford (AO) rats. DC were generated from bone marrow precursors and matured (mDC) by lipopolysaccharide. Tolerogenic DC (tolDC) obtained by vitamin D3 treatment were studied in parallel. Profile of cytokine production was different in AO and DA mDC and tolDC. Expression of MHC class II molecules and CD86 were higher in DA DC, while vitamin D3 reduced their expression in dendritic cells of both strains. Allogeneic proliferation of CD4(+) T cells was reduced by AO tolDC, but not with DA tolDC in comparison to respective mDC. Finally, expression of various genes identified as differentially expressed in human mDC and tolDC was also analyzed in AO and DA DC. Again, AO and DA DC differed in the expression of the analyzed genes. To conclude, AO and DA DC differ in production of cytokines, expression of antigen presentation-related molecules and in regulation of CD4(+) T proliferation. The difference is valuable for understanding the divergence of the strains in their susceptibility to autoimmunity.
PB  - Elsevier Gmbh, Munich
T2  - Immunobiology
T1  - Comparison of dendritic cells obtained from autoimmunty-prone and resistant rats
EP  - 476
IS  - 3
SP  - 470
VL  - 224
DO  - 10.1016/j.imbio.2019.01.001
ER  - 

@article{
author = "Đedović, Neda and Jevtić, Bojan and Jose Mansilla, M. and Petković, Filip and Blazevski, Jana and Timotijević, Gordana and Navarro-Barriuso, Juan and Martinez-Caceres, Eva and Mostarica Stojkovide, Marija and Miljković, Đorđe",
year = "2019",
abstract = "Dendritic cells (DC) are responsible for the initiation and shaping of the adaptive immune response and are in the focus of autoimmunity research. We were interested in comparison of DC obtained from autoimmunity-prone Dark Agouti (DA) rats and autoimmunity-resistant Albino Oxford (AO) rats. DC were generated from bone marrow precursors and matured (mDC) by lipopolysaccharide. Tolerogenic DC (tolDC) obtained by vitamin D3 treatment were studied in parallel. Profile of cytokine production was different in AO and DA mDC and tolDC. Expression of MHC class II molecules and CD86 were higher in DA DC, while vitamin D3 reduced their expression in dendritic cells of both strains. Allogeneic proliferation of CD4(+) T cells was reduced by AO tolDC, but not with DA tolDC in comparison to respective mDC. Finally, expression of various genes identified as differentially expressed in human mDC and tolDC was also analyzed in AO and DA DC. Again, AO and DA DC differed in the expression of the analyzed genes. To conclude, AO and DA DC differ in production of cytokines, expression of antigen presentation-related molecules and in regulation of CD4(+) T proliferation. The difference is valuable for understanding the divergence of the strains in their susceptibility to autoimmunity.",
publisher = "Elsevier Gmbh, Munich",
journal = "Immunobiology",
title = "Comparison of dendritic cells obtained from autoimmunty-prone and resistant rats",
pages = "476-470",
number = "3",
volume = "224",
doi = "10.1016/j.imbio.2019.01.001"
}

Đedović, N., Jevtić, B., Jose Mansilla, M., Petković, F., Blazevski, J., Timotijević, G., Navarro-Barriuso, J., Martinez-Caceres, E., Mostarica Stojkovide, M.,& Miljković, Đ.. (2019). Comparison of dendritic cells obtained from autoimmunty-prone and resistant rats. in Immunobiology
Elsevier Gmbh, Munich., 224(3), 470-476.
https://doi.org/10.1016/j.imbio.2019.01.001

Đedović N, Jevtić B, Jose Mansilla M, Petković F, Blazevski J, Timotijević G, Navarro-Barriuso J, Martinez-Caceres E, Mostarica Stojkovide M, Miljković Đ. Comparison of dendritic cells obtained from autoimmunty-prone and resistant rats. in Immunobiology. 2019;224(3):470-476.
doi:10.1016/j.imbio.2019.01.001 .

Đedović, Neda, Jevtić, Bojan, Jose Mansilla, M., Petković, Filip, Blazevski, Jana, Timotijević, Gordana, Navarro-Barriuso, Juan, Martinez-Caceres, Eva, Mostarica Stojkovide, Marija, Miljković, Đorđe, "Comparison of dendritic cells obtained from autoimmunty-prone and resistant rats" in Immunobiology, 224, no. 3 (2019):470-476,
https://doi.org/10.1016/j.imbio.2019.01.001 . .