TY  - JOUR
AU  - Jevtovic-Stoimenov, Tatjana
AU  - Kocić, Gordana
AU  - Pavlović, Dušica
AU  - Macukanović-Golubović, Lana
AU  - Marjanović, Goran
AU  - Đorđević, Vidosava
AU  - Tošić, Nataša
AU  - Pavlović, Sonja
PY  - 2008
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/317
AB  - Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) have been shown to play an important role in the pathogenesis of limphoproliferative disease. Both cytokines regulate cell-survival and cell-death in leukemic cells. TNF-alpha and LT-alpha are highly produced in chronic lymphotic leukemia (CLL) and non-Hodgkin lymphoma (NHL) patients. Genetic polymorphism within regulatory regions of these cytokine genes can alter their expression levels. This study investigates an influence of TNF-alpha - 308 and LT-alpha + 250 polymorphisms on the activity of alkaline DNase in mononuclear cells of both patient groups as a potent biochemical marker of DNA fragmentation in the terminal phase of apoptosis. Study was performed on mononuclear cells of CLL and NHL patients. SNP were obtained by PCR-RFLP method. The activity of alkaline DNase was measured by spectrophotometric method. The study provided evidence of the influence of TNFG/A genotype and A alleles in the susceptibility to NHL, since the association of LT-alpha G/G genotype with CLL was observed. High-producing TNF-alpha - 308/LT-alpha + 250 heterozygous haplotype is associated with high NHL incidence. The investigated SNP influence the activity of alkaline DNase in CLL and NHL patients. The observed polymorphisms may modulate susceptibility of leukemic cells to apoptosis by way of DNase activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Leukemia & Lymphoma
T1  - Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells
EP  - 2180
IS  - 11
SP  - 2174
VL  - 49
DO  - 10.1080/10428190802381220
ER  - 

@article{
author = "Jevtovic-Stoimenov, Tatjana and Kocić, Gordana and Pavlović, Dušica and Macukanović-Golubović, Lana and Marjanović, Goran and Đorđević, Vidosava and Tošić, Nataša and Pavlović, Sonja",
year = "2008",
abstract = "Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) have been shown to play an important role in the pathogenesis of limphoproliferative disease. Both cytokines regulate cell-survival and cell-death in leukemic cells. TNF-alpha and LT-alpha are highly produced in chronic lymphotic leukemia (CLL) and non-Hodgkin lymphoma (NHL) patients. Genetic polymorphism within regulatory regions of these cytokine genes can alter their expression levels. This study investigates an influence of TNF-alpha - 308 and LT-alpha + 250 polymorphisms on the activity of alkaline DNase in mononuclear cells of both patient groups as a potent biochemical marker of DNA fragmentation in the terminal phase of apoptosis. Study was performed on mononuclear cells of CLL and NHL patients. SNP were obtained by PCR-RFLP method. The activity of alkaline DNase was measured by spectrophotometric method. The study provided evidence of the influence of TNFG/A genotype and A alleles in the susceptibility to NHL, since the association of LT-alpha G/G genotype with CLL was observed. High-producing TNF-alpha - 308/LT-alpha + 250 heterozygous haplotype is associated with high NHL incidence. The investigated SNP influence the activity of alkaline DNase in CLL and NHL patients. The observed polymorphisms may modulate susceptibility of leukemic cells to apoptosis by way of DNase activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Leukemia & Lymphoma",
title = "Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells",
pages = "2180-2174",
number = "11",
volume = "49",
doi = "10.1080/10428190802381220"
}

Jevtovic-Stoimenov, T., Kocić, G., Pavlović, D., Macukanović-Golubović, L., Marjanović, G., Đorđević, V., Tošić, N.,& Pavlović, S.. (2008). Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells. in Leukemia & Lymphoma
Taylor & Francis Ltd, Abingdon., 49(11), 2174-2180.
https://doi.org/10.1080/10428190802381220

Jevtovic-Stoimenov T, Kocić G, Pavlović D, Macukanović-Golubović L, Marjanović G, Đorđević V, Tošić N, Pavlović S. Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells. in Leukemia & Lymphoma. 2008;49(11):2174-2180.
doi:10.1080/10428190802381220 .

Jevtovic-Stoimenov, Tatjana, Kocić, Gordana, Pavlović, Dušica, Macukanović-Golubović, Lana, Marjanović, Goran, Đorđević, Vidosava, Tošić, Nataša, Pavlović, Sonja, "Polymorphisms of tumor-necrosis factor-alpha-7308 and lymphotoxin-alpha+250: Possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells" in Leukemia & Lymphoma, 49, no. 11 (2008):2174-2180,
https://doi.org/10.1080/10428190802381220 . .