TY  - JOUR
AU  - Rodić, Predrag
AU  - Pavlović, Sonja
AU  - Kostić, Tatjana
AU  - Suvajdžić-Vuković, Nada
AU  - Đorđević, Maja
AU  - Sumarac, Zorica
AU  - Dajak, Marijana
AU  - Bonaci-Nikolić, Branka
AU  - Janić, Dragana
PY  - 2013
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/621
AB  - Introduction: We evaluated a novel approach for investigation of lymphocyte dysregulation in Gaucher patients by including determination of IgH and TCR gene rearrangements together with levels of immunoglobulins, natural autoantibodies as well as presence of monoclonal protein. Materials and methods: Measurement of serum immunoglobulins, monoclonal immunoglobulins, selected autoantibodies, as well as analysis of immunoglobulin heavy chain and T cell receptor gene rearrangements. Results: Immunoglobulin disorder was detected in 29.6% patients, 40.7% demonstrated presence of B cell clonality and 44.4% demonstrated presence of autoantibodies. In five patients in our series, the presence of IgH gene rearrangement was the only detectable indicator of B cell dysfunction. TCR gene rearrangements were not found in any of the patients. Conclusion: Based on our results, we propose IgH gene rearrangements as a new biomarker for investigation of B cell dysfunction occurring as a complication of Gaucher disease.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Blood Cells Molecules and Diseases
T1  - Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease
EP  - 225
IS  - 3
SP  - 222
VL  - 50
DO  - 10.1016/j.bcmd.2012.11.012
ER  - 

@article{
author = "Rodić, Predrag and Pavlović, Sonja and Kostić, Tatjana and Suvajdžić-Vuković, Nada and Đorđević, Maja and Sumarac, Zorica and Dajak, Marijana and Bonaci-Nikolić, Branka and Janić, Dragana",
year = "2013",
abstract = "Introduction: We evaluated a novel approach for investigation of lymphocyte dysregulation in Gaucher patients by including determination of IgH and TCR gene rearrangements together with levels of immunoglobulins, natural autoantibodies as well as presence of monoclonal protein. Materials and methods: Measurement of serum immunoglobulins, monoclonal immunoglobulins, selected autoantibodies, as well as analysis of immunoglobulin heavy chain and T cell receptor gene rearrangements. Results: Immunoglobulin disorder was detected in 29.6% patients, 40.7% demonstrated presence of B cell clonality and 44.4% demonstrated presence of autoantibodies. In five patients in our series, the presence of IgH gene rearrangement was the only detectable indicator of B cell dysfunction. TCR gene rearrangements were not found in any of the patients. Conclusion: Based on our results, we propose IgH gene rearrangements as a new biomarker for investigation of B cell dysfunction occurring as a complication of Gaucher disease.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Blood Cells Molecules and Diseases",
title = "Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease",
pages = "225-222",
number = "3",
volume = "50",
doi = "10.1016/j.bcmd.2012.11.012"
}

Rodić, P., Pavlović, S., Kostić, T., Suvajdžić-Vuković, N., Đorđević, M., Sumarac, Z., Dajak, M., Bonaci-Nikolić, B.,& Janić, D.. (2013). Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease. in Blood Cells Molecules and Diseases
Academic Press Inc Elsevier Science, San Diego., 50(3), 222-225.
https://doi.org/10.1016/j.bcmd.2012.11.012

Rodić P, Pavlović S, Kostić T, Suvajdžić-Vuković N, Đorđević M, Sumarac Z, Dajak M, Bonaci-Nikolić B, Janić D. Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease. in Blood Cells Molecules and Diseases. 2013;50(3):222-225.
doi:10.1016/j.bcmd.2012.11.012 .

Rodić, Predrag, Pavlović, Sonja, Kostić, Tatjana, Suvajdžić-Vuković, Nada, Đorđević, Maja, Sumarac, Zorica, Dajak, Marijana, Bonaci-Nikolić, Branka, Janić, Dragana, "Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease" in Blood Cells Molecules and Diseases, 50, no. 3 (2013):222-225,
https://doi.org/10.1016/j.bcmd.2012.11.012 . .