TY  - JOUR
AU  - Georgitsi, Marianthi
AU  - Zukić, Branka
AU  - Pavlović, Sonja
AU  - Patrinos, George P.
PY  - 2011
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/510
AB  - Interindividual variable drug response is correlated with sequence alterations in genes encoding drug-metabolizing enzymes and transporters, affecting drug absorption, distribution, metabolism and excretion. This variable drug response may have an impact on disease therapeutic outcomes, tolerance to adverse drug reactions and even survival. Sequence alterations may occur not only within the coding region of a gene, but in its regulatory elements too, affecting gene transcription and gene-expression levels. Here, we provide a compilation of the current knowledge of pharmacogenomics related to transcription, with a focus on the effect of SNPs and short tandem repeats residing in cis-regulatory elements of 11 genes encoding for drug-metabolizing enzymes and drug transporters. In addition, we comment on two genes encoding enzymes that are drug targets themselves. Finally, we briefly discuss the currently available methodologies for clinically assessing pharmacogenomic profiles, which could potentially in the future facilitate drug treatment-individualization via the identification of molecular signatures in specific patient groups.
PB  - Future Medicine Ltd, London
T2  - Pharmacogenomics
T1  - Transcriptional regulation and pharmacogenomics
EP  - 673
IS  - 5
SP  - 655
VL  - 12
DO  - 10.2217/PGS.10.215
ER  - 

@article{
author = "Georgitsi, Marianthi and Zukić, Branka and Pavlović, Sonja and Patrinos, George P.",
year = "2011",
abstract = "Interindividual variable drug response is correlated with sequence alterations in genes encoding drug-metabolizing enzymes and transporters, affecting drug absorption, distribution, metabolism and excretion. This variable drug response may have an impact on disease therapeutic outcomes, tolerance to adverse drug reactions and even survival. Sequence alterations may occur not only within the coding region of a gene, but in its regulatory elements too, affecting gene transcription and gene-expression levels. Here, we provide a compilation of the current knowledge of pharmacogenomics related to transcription, with a focus on the effect of SNPs and short tandem repeats residing in cis-regulatory elements of 11 genes encoding for drug-metabolizing enzymes and drug transporters. In addition, we comment on two genes encoding enzymes that are drug targets themselves. Finally, we briefly discuss the currently available methodologies for clinically assessing pharmacogenomic profiles, which could potentially in the future facilitate drug treatment-individualization via the identification of molecular signatures in specific patient groups.",
publisher = "Future Medicine Ltd, London",
journal = "Pharmacogenomics",
title = "Transcriptional regulation and pharmacogenomics",
pages = "673-655",
number = "5",
volume = "12",
doi = "10.2217/PGS.10.215"
}

Georgitsi, M., Zukić, B., Pavlović, S.,& Patrinos, G. P.. (2011). Transcriptional regulation and pharmacogenomics. in Pharmacogenomics
Future Medicine Ltd, London., 12(5), 655-673.
https://doi.org/10.2217/PGS.10.215

Georgitsi M, Zukić B, Pavlović S, Patrinos GP. Transcriptional regulation and pharmacogenomics. in Pharmacogenomics. 2011;12(5):655-673.
doi:10.2217/PGS.10.215 .

Georgitsi, Marianthi, Zukić, Branka, Pavlović, Sonja, Patrinos, George P., "Transcriptional regulation and pharmacogenomics" in Pharmacogenomics, 12, no. 5 (2011):655-673,
https://doi.org/10.2217/PGS.10.215 . .