TY  - JOUR
AU  - Thomadaki, Hellinida
AU  - Floros, Konstantinos V.
AU  - Pavlović, Sonja
AU  - Tošić, Nataša
AU  - Gourgiotis, Dimitrios
AU  - Colović, Milica
AU  - Scorilas, Andreas
PY  - 2012
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/611
AB  - Objectives: BCL2L12 is a recently discovered and cloned gene from members of our research team. It is a novel member of the BCL2 gene family, members of which are implicated in different hematological malignancies. In the present study, we investigated and studied the expression profile of BCL2L12 in acute myeloid leukemia (AML). Design and methods: Total RNA was isolated from peripheral blood of 67 AML patients and healthy donors. The expression profile of BCL2L12 was studied using real-time PCR methodology (SYBR Green chemistry). We also evaluated the association of the BCL2L12 mRNA expression level with clinical and pathological disease parameters, as well with disease-free survival (DFS) and overall survival (OS), using the chi-square (chi(2)) test or the Fisher's exact test, where appropriate. Results: Leukemia patients expressing high level of BCL2L12 were 3 times more likely to relapse (p=0.004) or die (p=0.007) than patients with low level of BCL2L12 expression. Additionally, statistically significant relationships were revealed between BCL2L12 expression level and CD117 expression, the presence of splenomegaly and chemotherapy response. Conclusions: Our results suggest that BCL2L12 can be considered as a new independent prognostic and chemotherapy response marker in AML
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia
EP  - 1367
IS  - 16-17
SP  - 1362
VL  - 45
DO  - 10.1016/j.clinbiochem.2012.06.012
ER  - 

@article{
author = "Thomadaki, Hellinida and Floros, Konstantinos V. and Pavlović, Sonja and Tošić, Nataša and Gourgiotis, Dimitrios and Colović, Milica and Scorilas, Andreas",
year = "2012",
abstract = "Objectives: BCL2L12 is a recently discovered and cloned gene from members of our research team. It is a novel member of the BCL2 gene family, members of which are implicated in different hematological malignancies. In the present study, we investigated and studied the expression profile of BCL2L12 in acute myeloid leukemia (AML). Design and methods: Total RNA was isolated from peripheral blood of 67 AML patients and healthy donors. The expression profile of BCL2L12 was studied using real-time PCR methodology (SYBR Green chemistry). We also evaluated the association of the BCL2L12 mRNA expression level with clinical and pathological disease parameters, as well with disease-free survival (DFS) and overall survival (OS), using the chi-square (chi(2)) test or the Fisher's exact test, where appropriate. Results: Leukemia patients expressing high level of BCL2L12 were 3 times more likely to relapse (p=0.004) or die (p=0.007) than patients with low level of BCL2L12 expression. Additionally, statistically significant relationships were revealed between BCL2L12 expression level and CD117 expression, the presence of splenomegaly and chemotherapy response. Conclusions: Our results suggest that BCL2L12 can be considered as a new independent prognostic and chemotherapy response marker in AML",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia",
pages = "1367-1362",
number = "16-17",
volume = "45",
doi = "10.1016/j.clinbiochem.2012.06.012"
}

Thomadaki, H., Floros, K. V., Pavlović, S., Tošić, N., Gourgiotis, D., Colović, M.,& Scorilas, A.. (2012). Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 45(16-17), 1362-1367.
https://doi.org/10.1016/j.clinbiochem.2012.06.012

Thomadaki H, Floros KV, Pavlović S, Tošić N, Gourgiotis D, Colović M, Scorilas A. Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia. in Clinical Biochemistry. 2012;45(16-17):1362-1367.
doi:10.1016/j.clinbiochem.2012.06.012 .

Thomadaki, Hellinida, Floros, Konstantinos V., Pavlović, Sonja, Tošić, Nataša, Gourgiotis, Dimitrios, Colović, Milica, Scorilas, Andreas, "Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia" in Clinical Biochemistry, 45, no. 16-17 (2012):1362-1367,
https://doi.org/10.1016/j.clinbiochem.2012.06.012 . .