TY  - JOUR
AU  - Divac Rankov, Aleksandra
AU  - Nikolić, Aleksandra
AU  - Mitić-Milikić, M.
AU  - Nagorni-Obradović, L.
AU  - Petrović-Stanojević, Nataša
AU  - Dopudja-Pantić, V.
AU  - Nadaskić, R.
AU  - Savić, A.
AU  - Radojković, Dragica
PY  - 2004
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/199
AB  - We performed the complete screening of the CFTR gene in a group of 31 patients with COPD in order to investigate the impact of mutations and polymorphisms in the CFTR gene. The cumulative frequency of CFTR mutations (17.74%) was significantly higher than in our general population (P  lt 0.0001). The R75Q was significantly overrepresented in COPD patients (8.06%; P =0.002). In all patients carrying the R75Q chronic bronchitis was a dominant symptom of COPD, and all were homozygous for the V470 allele. These findings suggest that R75Q mutation could be characteristic CFTR variant for COPD patients.
PB  - Elsevier
T2  - Journal of Cystic Fibrosis
T1  - High frequency of the R75Q CFTR variation in patients with chronic obstructive pulmonary disease
EP  - 191
IS  - 3
SP  - 189
VL  - 3
DO  - 10.1016/j.jcf.2004.05.049
ER  - 

@article{
author = "Divac Rankov, Aleksandra and Nikolić, Aleksandra and Mitić-Milikić, M. and Nagorni-Obradović, L. and Petrović-Stanojević, Nataša and Dopudja-Pantić, V. and Nadaskić, R. and Savić, A. and Radojković, Dragica",
year = "2004",
abstract = "We performed the complete screening of the CFTR gene in a group of 31 patients with COPD in order to investigate the impact of mutations and polymorphisms in the CFTR gene. The cumulative frequency of CFTR mutations (17.74%) was significantly higher than in our general population (P  lt 0.0001). The R75Q was significantly overrepresented in COPD patients (8.06%; P =0.002). In all patients carrying the R75Q chronic bronchitis was a dominant symptom of COPD, and all were homozygous for the V470 allele. These findings suggest that R75Q mutation could be characteristic CFTR variant for COPD patients.",
publisher = "Elsevier",
journal = "Journal of Cystic Fibrosis",
title = "High frequency of the R75Q CFTR variation in patients with chronic obstructive pulmonary disease",
pages = "191-189",
number = "3",
volume = "3",
doi = "10.1016/j.jcf.2004.05.049"
}

Divac Rankov, A., Nikolić, A., Mitić-Milikić, M., Nagorni-Obradović, L., Petrović-Stanojević, N., Dopudja-Pantić, V., Nadaskić, R., Savić, A.,& Radojković, D.. (2004). High frequency of the R75Q CFTR variation in patients with chronic obstructive pulmonary disease. in Journal of Cystic Fibrosis
Elsevier., 3(3), 189-191.
https://doi.org/10.1016/j.jcf.2004.05.049

Divac Rankov A, Nikolić A, Mitić-Milikić M, Nagorni-Obradović L, Petrović-Stanojević N, Dopudja-Pantić V, Nadaskić R, Savić A, Radojković D. High frequency of the R75Q CFTR variation in patients with chronic obstructive pulmonary disease. in Journal of Cystic Fibrosis. 2004;3(3):189-191.
doi:10.1016/j.jcf.2004.05.049 .

Divac Rankov, Aleksandra, Nikolić, Aleksandra, Mitić-Milikić, M., Nagorni-Obradović, L., Petrović-Stanojević, Nataša, Dopudja-Pantić, V., Nadaskić, R., Savić, A., Radojković, Dragica, "High frequency of the R75Q CFTR variation in patients with chronic obstructive pulmonary disease" in Journal of Cystic Fibrosis, 3, no. 3 (2004):189-191,
https://doi.org/10.1016/j.jcf.2004.05.049 . .