Prehrambeni proizvodi za grupe potrošača sa specijalnim zahtevima i potrebama

Link to this page

http://imagine.imgge.bg.ac.rs/APP/faces/project.xhtml?project_id=info%3Aeu-repo%2FgrantAgreement%2FMESTD%2FMPN2006-2010%2F20068%2FRS%2F%2F&item_offset=0&author_offset=0&sort_by=dc.date.issued

info:eu-repo/grantAgreement/MESTD/MPN2006-2010/20068/RS//

Prehrambeni proizvodi za grupe potrošača sa specijalnim zahtevima i potrebama (en)
Прехрамбени производи за групе потрошача са специјалним захтевима и потребама (sr)
Prehrambeni proizvodi za grupe potrošača sa specijalnim zahtevima i potrebama (sr_RS)
Authors

Publications

Prothrombin 3’ end gene variants in isolated pulmonary embolism – The first report of FIIc.*64_*66del and FIIc.*303T gt C variants

Gvozdenov, Maja; Pruner, Iva; Tomić, Branko; Aradjanski, Marijana; Antonijević, Nebojša; Radojković, Dragica; Đorđević, Valentina

(Acta Cardiologica, 2015) 

TY  - JOUR
AU  - Gvozdenov, Maja
AU  - Pruner, Iva
AU  - Tomić, Branko
AU  - Aradjanski, Marijana
AU  - Antonijević, Nebojša
AU  - Radojković, Dragica
AU  - Đorđević, Valentina
PY  - 2015
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/871
AB  - Objective Pulmonary embolism is usually considered as a complication of deep vein thrombosis, but there are still a number of cases of isolated pulmonary embolism. We aimed to investigate whether prothrombin 3’ end gene variants might play a signifi cant role in the pathogenesis of isolated pulmonary embolism. Methods and results In this study 100 patients with isolated pulmonary embolism and 100 controls were screened by DNA sequencing. Screening included last intron, last exon, 3’UTR and part of the 3’FR region of the prothrombin gene. Our results have shown that heterozygous carriers of the FII G20210A variant have a signifi cantly higher risk of isolated pulmonary embolism (OR 4.83; 95%CI 1.33-17.52; P = 0.02). Carriers of the FII 19911GG genotype (OR 1.41; 95%CI 0.72-2.73; P = 0.31) and FII 20068CT genotype (OR 3.06; 95%CI 0.31-29.95; P = 0.34) were more frequent in patients with isolated pulmonary embolism compared to controls. We also detected the novel gene variants, FIIc.*64_*66del and FII c.*303T gt C, in two patients. Conclusions Our results suggest that FII G20210A represents a signifi cant risk factor for isolated pulmonary embolism. The FII G19911A and FII C20068T are potentially associated with an increased risk for the occurrence of isolated pulmonary embolism, but the results did not reach statistical signifi cance. This is the fi rst study in which the two novel 3’ end prothrombin gene variants, FIIc.*64_*66del and FII c.*303T gt C, were reported.
PB  - Acta Cardiologica
T2  - Acta Cardiologica
T1  - Prothrombin 3’ end gene variants in isolated pulmonary embolism – The first report of FIIc.*64_*66del and FIIc.*303T gt C variants
EP  - 182
IS  - 2
SP  - 177
VL  - 70
DO  - 10.2143/AC.70.2.3073509
ER  - 
@article{
author = "Gvozdenov, Maja and Pruner, Iva and Tomić, Branko and Aradjanski, Marijana and Antonijević, Nebojša and Radojković, Dragica and Đorđević, Valentina",
year = "2015",
abstract = "Objective Pulmonary embolism is usually considered as a complication of deep vein thrombosis, but there are still a number of cases of isolated pulmonary embolism. We aimed to investigate whether prothrombin 3’ end gene variants might play a signifi cant role in the pathogenesis of isolated pulmonary embolism. Methods and results In this study 100 patients with isolated pulmonary embolism and 100 controls were screened by DNA sequencing. Screening included last intron, last exon, 3’UTR and part of the 3’FR region of the prothrombin gene. Our results have shown that heterozygous carriers of the FII G20210A variant have a signifi cantly higher risk of isolated pulmonary embolism (OR 4.83; 95%CI 1.33-17.52; P = 0.02). Carriers of the FII 19911GG genotype (OR 1.41; 95%CI 0.72-2.73; P = 0.31) and FII 20068CT genotype (OR 3.06; 95%CI 0.31-29.95; P = 0.34) were more frequent in patients with isolated pulmonary embolism compared to controls. We also detected the novel gene variants, FIIc.*64_*66del and FII c.*303T gt C, in two patients. Conclusions Our results suggest that FII G20210A represents a signifi cant risk factor for isolated pulmonary embolism. The FII G19911A and FII C20068T are potentially associated with an increased risk for the occurrence of isolated pulmonary embolism, but the results did not reach statistical signifi cance. This is the fi rst study in which the two novel 3’ end prothrombin gene variants, FIIc.*64_*66del and FII c.*303T gt C, were reported.",
publisher = "Acta Cardiologica",
journal = "Acta Cardiologica",
title = "Prothrombin 3’ end gene variants in isolated pulmonary embolism – The first report of FIIc.*64_*66del and FIIc.*303T gt C variants",
pages = "182-177",
number = "2",
volume = "70",
doi = "10.2143/AC.70.2.3073509"
}
Gvozdenov, M., Pruner, I., Tomić, B., Aradjanski, M., Antonijević, N., Radojković, D.,& Đorđević, V.. (2015). Prothrombin 3’ end gene variants in isolated pulmonary embolism – The first report of FIIc.*64_*66del and FIIc.*303T gt C variants. in Acta Cardiologica
Acta Cardiologica., 70(2), 177-182.
https://doi.org/10.2143/AC.70.2.3073509
Gvozdenov M, Pruner I, Tomić B, Aradjanski M, Antonijević N, Radojković D, Đorđević V. Prothrombin 3’ end gene variants in isolated pulmonary embolism – The first report of FIIc.*64_*66del and FIIc.*303T gt C variants. in Acta Cardiologica. 2015;70(2):177-182.
doi:10.2143/AC.70.2.3073509 .
Gvozdenov, Maja, Pruner, Iva, Tomić, Branko, Aradjanski, Marijana, Antonijević, Nebojša, Radojković, Dragica, Đorđević, Valentina, "Prothrombin 3’ end gene variants in isolated pulmonary embolism – The first report of FIIc.*64_*66del and FIIc.*303T gt C variants" in Acta Cardiologica, 70, no. 2 (2015):177-182,
https://doi.org/10.2143/AC.70.2.3073509 . .
1
2