@article{
author = "Stodulkova, Eva and Kuzma, Marek and Hench, Ivana Bratic and Cerny, Jan and Kralova, Jarmila and Novak, Petr and Chudickova, Milada and Savić, Miloje and Đokić, Lidija and Vasiljević, Branka and Flieger, Miroslav",
year = "2011",
abstract = "A new polyene macrolide family, closely related to the pentaene macrolide antibiotic roflamycoin, was isolated from the both fermentation broth and biomass of Streptomyces durmitorensis wild-type strain MS405. The main compound was identified by NMR and Fourier transform ion cyclotron resonance mass spectrometry as 32,33-didehydroroflamycoin (1; DDHR). Additional four structurally related compounds were determined solely by MS analysis. DDHR induces cell death by apoptosis in various cancer cell lines as demonstrated by DNA fragmentation. Striking feature of DDHR is its internal fluorescence allowing visualization of labeled plasma membranes and internal membrane structures. The Journal of Antibiotics (2011) 64, 717-722; doi:10.1038/ja.2011.81; published online 14 September 2011",
publisher = "Nature Publishing Group, London",
journal = "Journal of Antibiotics",
title = "New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis",
pages = "722-717",
number = "11",
volume = "64",
doi = "10.1038/ja.2011.81"
}