TY  - JOUR
AU  - Djikić Rom, Aleksandra
AU  - Dragičević, Sandra
AU  - Janković, Radmila
AU  - Radojević Skodric, Sanja
AU  - Sabljak, Predrag
AU  - Marković, Velimir
AU  - Stojković, Jovana Rosic
AU  - Barišić, Goran
AU  - Nikolić, Aleksandra
PY  - 2024
UR  - https://www.mdpi.com/2075-4418/14/14/1512
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/2483
AB  - Approximately 20% of patients with colorectal cancer (CRC) are diagnosed with a mucinous subtype of this tumor, have a worse prognosis, and often show resistance to available therapies. Molecules from the mucin family are involved in the regulation of epithelial–mesenchymal transition (EMT), which significantly determines the cancer aggressiveness. This study aimed to examine the diagnostic and prognostic significance of mucinous histology and EMT markers in patients with early-onset CRC and their association with disease severity and tumor characteristics. This study included tumor tissue samples from 106 patients diagnosed with CRC before the age of 45, 53 with mucinous and 53 with non-mucinous tumors. The EMT status was determined by immunohistochemical analysis of E-cadherin and Vimentin in tissue sections. Mucinous tumors had significantly higher Mucin-1 (p < 0.001) and cytoplasmic E-cadherin (p = 0.043) scores; they were significantly less differentiated (p = 0.007), more advanced (p = 0.027), and predominately affected right the colon (p = 0.039) compared to non-mucinous tumors. Epithelial tumors were significantly better differentiated (p = 0.034) and with less prominent tumor budding (p < 0.001) than mesenchymal tumors. Mucin-1 and Vimentin were independent predictors of tumor differentiation (p = 0.006) and budding (p = 0.001), respectively. Mucinous histology and EMT markers are significant predictors of disease severity and tumor characteristics in early-onset colorectal cancer.
PB  - MDPI
T2  - Diagnostics
T1  - Markers of Epithelial–Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer
IS  - 14
SP  - 1512
VL  - 14
DO  - 10.3390/diagnostics14141512
ER  - 

@article{
author = "Djikić Rom, Aleksandra and Dragičević, Sandra and Janković, Radmila and Radojević Skodric, Sanja and Sabljak, Predrag and Marković, Velimir and Stojković, Jovana Rosic and Barišić, Goran and Nikolić, Aleksandra",
year = "2024",
abstract = "Approximately 20% of patients with colorectal cancer (CRC) are diagnosed with a mucinous subtype of this tumor, have a worse prognosis, and often show resistance to available therapies. Molecules from the mucin family are involved in the regulation of epithelial–mesenchymal transition (EMT), which significantly determines the cancer aggressiveness. This study aimed to examine the diagnostic and prognostic significance of mucinous histology and EMT markers in patients with early-onset CRC and their association with disease severity and tumor characteristics. This study included tumor tissue samples from 106 patients diagnosed with CRC before the age of 45, 53 with mucinous and 53 with non-mucinous tumors. The EMT status was determined by immunohistochemical analysis of E-cadherin and Vimentin in tissue sections. Mucinous tumors had significantly higher Mucin-1 (p < 0.001) and cytoplasmic E-cadherin (p = 0.043) scores; they were significantly less differentiated (p = 0.007), more advanced (p = 0.027), and predominately affected right the colon (p = 0.039) compared to non-mucinous tumors. Epithelial tumors were significantly better differentiated (p = 0.034) and with less prominent tumor budding (p < 0.001) than mesenchymal tumors. Mucin-1 and Vimentin were independent predictors of tumor differentiation (p = 0.006) and budding (p = 0.001), respectively. Mucinous histology and EMT markers are significant predictors of disease severity and tumor characteristics in early-onset colorectal cancer.",
publisher = "MDPI",
journal = "Diagnostics",
title = "Markers of Epithelial–Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer",
number = "14",
pages = "1512",
volume = "14",
doi = "10.3390/diagnostics14141512"
}

Djikić Rom, A., Dragičević, S., Janković, R., Radojević Skodric, S., Sabljak, P., Marković, V., Stojković, J. R., Barišić, G.,& Nikolić, A.. (2024). Markers of Epithelial–Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer. in Diagnostics
MDPI., 14(14), 1512.
https://doi.org/10.3390/diagnostics14141512

Djikić Rom A, Dragičević S, Janković R, Radojević Skodric S, Sabljak P, Marković V, Stojković JR, Barišić G, Nikolić A. Markers of Epithelial–Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer. in Diagnostics. 2024;14(14):1512.
doi:10.3390/diagnostics14141512 .

Djikić Rom, Aleksandra, Dragičević, Sandra, Janković, Radmila, Radojević Skodric, Sanja, Sabljak, Predrag, Marković, Velimir, Stojković, Jovana Rosic, Barišić, Goran, Nikolić, Aleksandra, "Markers of Epithelial–Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer" in Diagnostics, 14, no. 14 (2024):1512,
https://doi.org/10.3390/diagnostics14141512 . .