TY  - JOUR
AU  - Mounier, Joelle
AU  - Boncompain, Gaelle
AU  - Šenerović, Lidija
AU  - Lagache, Thibault
AU  - Chretien, Fabrice
AU  - Perez, Franck
AU  - Kolbe, Michael
AU  - Olivo-Marin, Jean-Christophe
AU  - Sansonetti, Philippe J.
AU  - Sauvonnet, Nathalie
PY  - 2012
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/588
AB  - Shigella infection causes destruction of the human colonic epithelial barrier. The Golgi network and recycling endosomes are essential for maintaining epithelial barrier function. Here we show that Shigella epithelial invasion induces fragmentation of the Golgi complex with consequent inhibition of both secretion and retrograde transport in the infected host cell. Shigella induces tubulation of the Rab11-positive compartment, thereby affecting cell surface receptor recycling. The molecular process underlying the observed damage to the Golgi complex and receptor recycling is a massive redistribution of plasma membrane cholesterol to the sites of Shigella entry. IpaB, a virulence factor of Shigella that is known to bind cholesterol, is necessary and sufficient to induce Golgi fragmentation and reorganization of the recycling compartment. Shigella infection-induced Golgi disorganization was also observed in vivo, suggesting that this mechanism affecting the sorting of cell surface molecules likely contributes to host epithelial barrier disruption associated with Shigella pathogenesis.
PB  - Cell Press, Cambridge
T2  - Cell Host & Microbe
T1  - Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion
EP  - 389
IS  - 3
SP  - 381
VL  - 12
DO  - 10.1016/j.chom.2012.07.010
ER  - 

@article{
author = "Mounier, Joelle and Boncompain, Gaelle and Šenerović, Lidija and Lagache, Thibault and Chretien, Fabrice and Perez, Franck and Kolbe, Michael and Olivo-Marin, Jean-Christophe and Sansonetti, Philippe J. and Sauvonnet, Nathalie",
year = "2012",
abstract = "Shigella infection causes destruction of the human colonic epithelial barrier. The Golgi network and recycling endosomes are essential for maintaining epithelial barrier function. Here we show that Shigella epithelial invasion induces fragmentation of the Golgi complex with consequent inhibition of both secretion and retrograde transport in the infected host cell. Shigella induces tubulation of the Rab11-positive compartment, thereby affecting cell surface receptor recycling. The molecular process underlying the observed damage to the Golgi complex and receptor recycling is a massive redistribution of plasma membrane cholesterol to the sites of Shigella entry. IpaB, a virulence factor of Shigella that is known to bind cholesterol, is necessary and sufficient to induce Golgi fragmentation and reorganization of the recycling compartment. Shigella infection-induced Golgi disorganization was also observed in vivo, suggesting that this mechanism affecting the sorting of cell surface molecules likely contributes to host epithelial barrier disruption associated with Shigella pathogenesis.",
publisher = "Cell Press, Cambridge",
journal = "Cell Host & Microbe",
title = "Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion",
pages = "389-381",
number = "3",
volume = "12",
doi = "10.1016/j.chom.2012.07.010"
}

Mounier, J., Boncompain, G., Šenerović, L., Lagache, T., Chretien, F., Perez, F., Kolbe, M., Olivo-Marin, J., Sansonetti, P. J.,& Sauvonnet, N.. (2012). Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion. in Cell Host & Microbe
Cell Press, Cambridge., 12(3), 381-389.
https://doi.org/10.1016/j.chom.2012.07.010

Mounier J, Boncompain G, Šenerović L, Lagache T, Chretien F, Perez F, Kolbe M, Olivo-Marin J, Sansonetti PJ, Sauvonnet N. Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion. in Cell Host & Microbe. 2012;12(3):381-389.
doi:10.1016/j.chom.2012.07.010 .

Mounier, Joelle, Boncompain, Gaelle, Šenerović, Lidija, Lagache, Thibault, Chretien, Fabrice, Perez, Franck, Kolbe, Michael, Olivo-Marin, Jean-Christophe, Sansonetti, Philippe J., Sauvonnet, Nathalie, "Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion" in Cell Host & Microbe, 12, no. 3 (2012):381-389,
https://doi.org/10.1016/j.chom.2012.07.010 . .