Characterization and application of fungal metabolites and assessment of new biofungicides potential

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Characterization and application of fungal metabolites and assessment of new biofungicides potential (en)
Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (sr)
Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (sr_RS)
Authors

Publications

Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma

Petrović, Jovana; Glamoclija, Jasmina; Ilić-Tomić, Tatjana; Soković, Marina; Robajac, Dragana; Nedić, Olgica; Pavić, Aleksandar

(Elsevier, Amsterdam, 2020)

TY  - JOUR
AU  - Petrović, Jovana
AU  - Glamoclija, Jasmina
AU  - Ilić-Tomić, Tatjana
AU  - Soković, Marina
AU  - Robajac, Dragana
AU  - Nedić, Olgica
AU  - Pavić, Aleksandar
PY  - 2020
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1383
AB  - In spite of extensive usage of Laetiporus sulphureus (sulphur polypore) in traditional European and Asian ethnomedicine for centuries, its anticancer therapeutic potential and toxicity profile remained explored in animal models. Herein, using zebrafish (Danio rerio), as a preclinical animal model, we demonstrated that L sulphureus lectin (LSL) and ethanol extract (LSE) are non-toxic at high doses up to 400-500 mu g/mL, while they effectively inhibited angiogenesis and cancer development at much lower doses. Lectin showed 74-fold higher antiangiogenic potency than the extract, and even 378-fold higher therapeutic potential than sunitinib-malate, cardiotoxic and myelosupressive anti-angiogenic drug of clinical relevance. Using wound healing and MTT assays, we proved LSL's strong anti-migratory effect and selective endothelial cytotoxidty in relation to lung fibro-blasts. In addition, employing the zebrafish xenograft models, we demonstrated that LSL almost completely reduced growth, neovascularization and metastasis of human colorectal carcinoma and mouse melanoma. Even more, LSL exerted 8-fold higher potency towards colorectal carcinoma than melanoma, showing markedly higher activity than cisplatin, while LSE failed to express any anticancer activity. Accompanied with non-toxic response, including neutropenia and inflammation, the results of this study strongly imply that LSL could be used as safe adjuvant in chemotherapy against colorectal carcinoma and melanoma.
PB  - Elsevier, Amsterdam
T2  - International Journal of Biological Macromolecules
T1  - Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma
EP  - 139
SP  - 129
VL  - 148
DO  - 10.1016/j.ijbiomac.2020.01.033
ER  - 
@article{
author = "Petrović, Jovana and Glamoclija, Jasmina and Ilić-Tomić, Tatjana and Soković, Marina and Robajac, Dragana and Nedić, Olgica and Pavić, Aleksandar",
year = "2020",
abstract = "In spite of extensive usage of Laetiporus sulphureus (sulphur polypore) in traditional European and Asian ethnomedicine for centuries, its anticancer therapeutic potential and toxicity profile remained explored in animal models. Herein, using zebrafish (Danio rerio), as a preclinical animal model, we demonstrated that L sulphureus lectin (LSL) and ethanol extract (LSE) are non-toxic at high doses up to 400-500 mu g/mL, while they effectively inhibited angiogenesis and cancer development at much lower doses. Lectin showed 74-fold higher antiangiogenic potency than the extract, and even 378-fold higher therapeutic potential than sunitinib-malate, cardiotoxic and myelosupressive anti-angiogenic drug of clinical relevance. Using wound healing and MTT assays, we proved LSL's strong anti-migratory effect and selective endothelial cytotoxidty in relation to lung fibro-blasts. In addition, employing the zebrafish xenograft models, we demonstrated that LSL almost completely reduced growth, neovascularization and metastasis of human colorectal carcinoma and mouse melanoma. Even more, LSL exerted 8-fold higher potency towards colorectal carcinoma than melanoma, showing markedly higher activity than cisplatin, while LSE failed to express any anticancer activity. Accompanied with non-toxic response, including neutropenia and inflammation, the results of this study strongly imply that LSL could be used as safe adjuvant in chemotherapy against colorectal carcinoma and melanoma.",
publisher = "Elsevier, Amsterdam",
journal = "International Journal of Biological Macromolecules",
title = "Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma",
pages = "139-129",
volume = "148",
doi = "10.1016/j.ijbiomac.2020.01.033"
}
Petrović, J., Glamoclija, J., Ilić-Tomić, T., Soković, M., Robajac, D., Nedić, O.,& Pavić, A.. (2020). Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma. in International Journal of Biological Macromolecules
Elsevier, Amsterdam., 148, 129-139.
https://doi.org/10.1016/j.ijbiomac.2020.01.033
Petrović J, Glamoclija J, Ilić-Tomić T, Soković M, Robajac D, Nedić O, Pavić A. Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma. in International Journal of Biological Macromolecules. 2020;148:129-139.
doi:10.1016/j.ijbiomac.2020.01.033 .
Petrović, Jovana, Glamoclija, Jasmina, Ilić-Tomić, Tatjana, Soković, Marina, Robajac, Dragana, Nedić, Olgica, Pavić, Aleksandar, "Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma" in International Journal of Biological Macromolecules, 148 (2020):129-139,
https://doi.org/10.1016/j.ijbiomac.2020.01.033 . .
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Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract

Stojković, Dejan S.; Kovačević Grujičić, Nataša; Reis, Filipa S.; Davidović, Slobodan; Barros, Lillian; Popović, Jelena; Petrović, Isidora; Pavić, Aleksandar; Glamoclija, Jasmina; Cirić, Ana; Stevanović, Milena; Ferreira, Isabel C. F. R.; Soković, Marina

(Elsevier Science Bv, Amsterdam, 2017)

TY  - JOUR
AU  - Stojković, Dejan S.
AU  - Kovačević Grujičić, Nataša
AU  - Reis, Filipa S.
AU  - Davidović, Slobodan
AU  - Barros, Lillian
AU  - Popović, Jelena
AU  - Petrović, Isidora
AU  - Pavić, Aleksandar
AU  - Glamoclija, Jasmina
AU  - Cirić, Ana
AU  - Stevanović, Milena
AU  - Ferreira, Isabel C. F. R.
AU  - Soković, Marina
PY  - 2017
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1051
AB  - Wild Meripilus giganteus Karst belongs to the order Polyporales, in which some members are known to possess a wide range of pharmacological properties. M. giganteus showed to be rich in carbohydrates (74.49 g/100 g) and proteins (15.94 g/100 g), presenting low fat content (1.51 g/100 g). Chemical composition was determined by using chromatographic techniques. Also, various bioactive compounds were detected including all four tocopherol isoforms with delta- and gamma-tocopherols being predominant (123.35 and 77.80 mu g/100 g, respectively); five organic acids (oxalic, malic, quinic, citric and fumaric acids) with predominant malic acid (3.17 g/100 g); and three phenolic acids and related compounds (p-hydroxybenzoic, p-coumaric and cinnamic acids; 1010, 2420 and 340 mu g/100 g, respectively). M. giganteus methanolic extract exhibited antioxidant activity tested by five different assays with the strongest potential in TBARS assay (EC50 0.31 mg/mL); and antimicrobial activities (MIC/MBC 0.0125-5 mg/mL; MIC/MFC 0.025-0.4 mg/mL). Furthermore, treatment of cervical carcinoma cell line (HeLa) led to reduction in cell's viability in MTT assay (lC(50) 0.41 mg/mL after 48 h), induced process of apoptosis and inhibited cell's migration in vitro. The analysed extract was not toxic for zebrafish embryos (at 0.5 mg/mL), indicating its biosafety and potential application as a dietary supplement in chemoprevention.
PB  - Elsevier Science Bv, Amsterdam
T2  - Lwt-Food Science and Technology
T1  - Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract
EP  - 462
SP  - 454
VL  - 79
DO  - 10.1016/j.lwt.2017.01.045
ER  - 
@article{
author = "Stojković, Dejan S. and Kovačević Grujičić, Nataša and Reis, Filipa S. and Davidović, Slobodan and Barros, Lillian and Popović, Jelena and Petrović, Isidora and Pavić, Aleksandar and Glamoclija, Jasmina and Cirić, Ana and Stevanović, Milena and Ferreira, Isabel C. F. R. and Soković, Marina",
year = "2017",
abstract = "Wild Meripilus giganteus Karst belongs to the order Polyporales, in which some members are known to possess a wide range of pharmacological properties. M. giganteus showed to be rich in carbohydrates (74.49 g/100 g) and proteins (15.94 g/100 g), presenting low fat content (1.51 g/100 g). Chemical composition was determined by using chromatographic techniques. Also, various bioactive compounds were detected including all four tocopherol isoforms with delta- and gamma-tocopherols being predominant (123.35 and 77.80 mu g/100 g, respectively); five organic acids (oxalic, malic, quinic, citric and fumaric acids) with predominant malic acid (3.17 g/100 g); and three phenolic acids and related compounds (p-hydroxybenzoic, p-coumaric and cinnamic acids; 1010, 2420 and 340 mu g/100 g, respectively). M. giganteus methanolic extract exhibited antioxidant activity tested by five different assays with the strongest potential in TBARS assay (EC50 0.31 mg/mL); and antimicrobial activities (MIC/MBC 0.0125-5 mg/mL; MIC/MFC 0.025-0.4 mg/mL). Furthermore, treatment of cervical carcinoma cell line (HeLa) led to reduction in cell's viability in MTT assay (lC(50) 0.41 mg/mL after 48 h), induced process of apoptosis and inhibited cell's migration in vitro. The analysed extract was not toxic for zebrafish embryos (at 0.5 mg/mL), indicating its biosafety and potential application as a dietary supplement in chemoprevention.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Lwt-Food Science and Technology",
title = "Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract",
pages = "462-454",
volume = "79",
doi = "10.1016/j.lwt.2017.01.045"
}
Stojković, D. S., Kovačević Grujičić, N., Reis, F. S., Davidović, S., Barros, L., Popović, J., Petrović, I., Pavić, A., Glamoclija, J., Cirić, A., Stevanović, M., Ferreira, I. C. F. R.,& Soković, M.. (2017). Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract. in Lwt-Food Science and Technology
Elsevier Science Bv, Amsterdam., 79, 454-462.
https://doi.org/10.1016/j.lwt.2017.01.045
Stojković DS, Kovačević Grujičić N, Reis FS, Davidović S, Barros L, Popović J, Petrović I, Pavić A, Glamoclija J, Cirić A, Stevanović M, Ferreira ICFR, Soković M. Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract. in Lwt-Food Science and Technology. 2017;79:454-462.
doi:10.1016/j.lwt.2017.01.045 .
Stojković, Dejan S., Kovačević Grujičić, Nataša, Reis, Filipa S., Davidović, Slobodan, Barros, Lillian, Popović, Jelena, Petrović, Isidora, Pavić, Aleksandar, Glamoclija, Jasmina, Cirić, Ana, Stevanović, Milena, Ferreira, Isabel C. F. R., Soković, Marina, "Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract" in Lwt-Food Science and Technology, 79 (2017):454-462,
https://doi.org/10.1016/j.lwt.2017.01.045 . .
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Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions

Smiljković, Marija; Stanisavljević Ninković, Danijela; Stojković, Dejan; Petrović, Isidora; Vicentić, Jelena Marjanovic; Popović, Jelena; Grdadolnik, Simona Golic; Marković, Dejan; Sanković-Babić, Snežana; Glamoclija, Jasmina; Stevanović, Milena; Soković, Marina

(EXCLI Journal Managing Office, Dortmund, 2017)

TY  - JOUR
AU  - Smiljković, Marija
AU  - Stanisavljević Ninković, Danijela
AU  - Stojković, Dejan
AU  - Petrović, Isidora
AU  - Vicentić, Jelena Marjanovic
AU  - Popović, Jelena
AU  - Grdadolnik, Simona Golic
AU  - Marković, Dejan
AU  - Sanković-Babić, Snežana
AU  - Glamoclija, Jasmina
AU  - Stevanović, Milena
AU  - Soković, Marina
PY  - 2017
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1014
AB  - Bioactive potential of apigenin derivative apigenin-7-O-glucoside related to its antifungal activity on Candida spp. and cytotoxic effect on colon cancer cells was studied and compared with bioactive potential of apigenin. Antifungal activity was tested on 14 different isolates of Candida spp. using membrane permeability assay, measuring inhibition of reactive oxidative species and inhibition of CYP51 C. albicans enzyme. Cytotoxic potential of apigenin- 7-O-glucoside was tested on colon cancer HCT116 cells by measuring cell viability, apoptosis rate and apoptosis- and colon cancer-related gene expression. Obtained results indicated considerable antifungal activity of apigenin-7-O-glucoside towards all Candida isolates. Breakdown of C. albicans plasma membrane was achieved upon treatment with apigenin-7-O-glucoside for shorter period of time then with apigenin. Reduction of intra-and extracellular reactive oxidative species was achieved with minimum inhibitory concentrations of both compounds, suggesting that reactive oxidative species inhibition could be a mechanism of antifungal action. None of the compounds exhibited binding affinity to C. albicans CYP51 protein. Besides, apigenin-7-O-glucoside was more effective compared to apigenin in reduction of cell's viability and induction of cell death of HCT116 cells. Treatment with both compounds resulted in chromatin condensation, apoptotic bodies formation and apoptotic genes expression in HCT116 cells, but the apigenin-7-O-glucoside required a lower concentration to achieve the same effect. Compounds apigenin-7-O-glucoside and apigenin displayed prominent antifungal potential and cytotoxic effect on HCT116 cells. However, our results showed that apigenin-7-O-glucoside has more potent activity compared to apigenin in all assays that we used.
PB  - EXCLI Journal Managing Office, Dortmund
T2  - EXCLI Journal
T1  - Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions
EP  - 807
SP  - 795
VL  - 16
DO  - 10.17179/excli2017-300
ER  - 
@article{
author = "Smiljković, Marija and Stanisavljević Ninković, Danijela and Stojković, Dejan and Petrović, Isidora and Vicentić, Jelena Marjanovic and Popović, Jelena and Grdadolnik, Simona Golic and Marković, Dejan and Sanković-Babić, Snežana and Glamoclija, Jasmina and Stevanović, Milena and Soković, Marina",
year = "2017",
abstract = "Bioactive potential of apigenin derivative apigenin-7-O-glucoside related to its antifungal activity on Candida spp. and cytotoxic effect on colon cancer cells was studied and compared with bioactive potential of apigenin. Antifungal activity was tested on 14 different isolates of Candida spp. using membrane permeability assay, measuring inhibition of reactive oxidative species and inhibition of CYP51 C. albicans enzyme. Cytotoxic potential of apigenin- 7-O-glucoside was tested on colon cancer HCT116 cells by measuring cell viability, apoptosis rate and apoptosis- and colon cancer-related gene expression. Obtained results indicated considerable antifungal activity of apigenin-7-O-glucoside towards all Candida isolates. Breakdown of C. albicans plasma membrane was achieved upon treatment with apigenin-7-O-glucoside for shorter period of time then with apigenin. Reduction of intra-and extracellular reactive oxidative species was achieved with minimum inhibitory concentrations of both compounds, suggesting that reactive oxidative species inhibition could be a mechanism of antifungal action. None of the compounds exhibited binding affinity to C. albicans CYP51 protein. Besides, apigenin-7-O-glucoside was more effective compared to apigenin in reduction of cell's viability and induction of cell death of HCT116 cells. Treatment with both compounds resulted in chromatin condensation, apoptotic bodies formation and apoptotic genes expression in HCT116 cells, but the apigenin-7-O-glucoside required a lower concentration to achieve the same effect. Compounds apigenin-7-O-glucoside and apigenin displayed prominent antifungal potential and cytotoxic effect on HCT116 cells. However, our results showed that apigenin-7-O-glucoside has more potent activity compared to apigenin in all assays that we used.",
publisher = "EXCLI Journal Managing Office, Dortmund",
journal = "EXCLI Journal",
title = "Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions",
pages = "807-795",
volume = "16",
doi = "10.17179/excli2017-300"
}
Smiljković, M., Stanisavljević Ninković, D., Stojković, D., Petrović, I., Vicentić, J. M., Popović, J., Grdadolnik, S. G., Marković, D., Sanković-Babić, S., Glamoclija, J., Stevanović, M.,& Soković, M.. (2017). Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions. in EXCLI Journal
EXCLI Journal Managing Office, Dortmund., 16, 795-807.
https://doi.org/10.17179/excli2017-300
Smiljković M, Stanisavljević Ninković D, Stojković D, Petrović I, Vicentić JM, Popović J, Grdadolnik SG, Marković D, Sanković-Babić S, Glamoclija J, Stevanović M, Soković M. Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions. in EXCLI Journal. 2017;16:795-807.
doi:10.17179/excli2017-300 .
Smiljković, Marija, Stanisavljević Ninković, Danijela, Stojković, Dejan, Petrović, Isidora, Vicentić, Jelena Marjanovic, Popović, Jelena, Grdadolnik, Simona Golic, Marković, Dejan, Sanković-Babić, Snežana, Glamoclija, Jasmina, Stevanović, Milena, Soković, Marina, "Apigenin-7-o-glucoside versus apigenin: insight into the modes of anticandidal and cytotoxic actions" in EXCLI Journal, 16 (2017):795-807,
https://doi.org/10.17179/excli2017-300 . .
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Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid

Stojković, Dejan S.; Davidović, Slobodan; Zivković, Jelena; Glamoclija, Jasmina; Cirić, Ana; Stevanović, Milena; Ferreira, Isabel C. F. R.; Soković, Marina

(Taylor & Francis Ltd, Abingdon, 2013)

TY  - JOUR
AU  - Stojković, Dejan S.
AU  - Davidović, Slobodan
AU  - Zivković, Jelena
AU  - Glamoclija, Jasmina
AU  - Cirić, Ana
AU  - Stevanović, Milena
AU  - Ferreira, Isabel C. F. R.
AU  - Soković, Marina
PY  - 2013
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/658
AB  - Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his(+) revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound - protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Frontiers in Life Science
T1  - Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
EP  - 223
IS  - 3-4
SP  - 218
VL  - 7
DO  - 10.1080/21553769.2014.901925
ER  - 
@article{
author = "Stojković, Dejan S. and Davidović, Slobodan and Zivković, Jelena and Glamoclija, Jasmina and Cirić, Ana and Stevanović, Milena and Ferreira, Isabel C. F. R. and Soković, Marina",
year = "2013",
abstract = "Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his(+) revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound - protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Frontiers in Life Science",
title = "Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid",
pages = "223-218",
number = "3-4",
volume = "7",
doi = "10.1080/21553769.2014.901925"
}
Stojković, D. S., Davidović, S., Zivković, J., Glamoclija, J., Cirić, A., Stevanović, M., Ferreira, I. C. F. R.,& Soković, M.. (2013). Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. in Frontiers in Life Science
Taylor & Francis Ltd, Abingdon., 7(3-4), 218-223.
https://doi.org/10.1080/21553769.2014.901925
Stojković DS, Davidović S, Zivković J, Glamoclija J, Cirić A, Stevanović M, Ferreira ICFR, Soković M. Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. in Frontiers in Life Science. 2013;7(3-4):218-223.
doi:10.1080/21553769.2014.901925 .
Stojković, Dejan S., Davidović, Slobodan, Zivković, Jelena, Glamoclija, Jasmina, Cirić, Ana, Stevanović, Milena, Ferreira, Isabel C. F. R., Soković, Marina, "Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid" in Frontiers in Life Science, 7, no. 3-4 (2013):218-223,
https://doi.org/10.1080/21553769.2014.901925 . .
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Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action

Popović, Visnja; Zivković, Jelena; Davidović, Slobodan; Stevanović, Milena; Stojković, Dejan

(Bentham Science Publ Ltd, Sharjah, 2013)

TY  - JOUR
AU  - Popović, Visnja
AU  - Zivković, Jelena
AU  - Davidović, Slobodan
AU  - Stevanović, Milena
AU  - Stojković, Dejan
PY  - 2013
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/664
AB  - Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, beta-glucans, alpha-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Topics in Medicinal Chemistry
T1  - Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action
EP  - 2806
IS  - 21
SP  - 2791
VL  - 13
DO  - 10.2174/15680266113136660198
ER  - 
@article{
author = "Popović, Visnja and Zivković, Jelena and Davidović, Slobodan and Stevanović, Milena and Stojković, Dejan",
year = "2013",
abstract = "Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, beta-glucans, alpha-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Topics in Medicinal Chemistry",
title = "Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action",
pages = "2806-2791",
number = "21",
volume = "13",
doi = "10.2174/15680266113136660198"
}
Popović, V., Zivković, J., Davidović, S., Stevanović, M.,& Stojković, D.. (2013). Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action. in Current Topics in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 13(21), 2791-2806.
https://doi.org/10.2174/15680266113136660198
Popović V, Zivković J, Davidović S, Stevanović M, Stojković D. Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action. in Current Topics in Medicinal Chemistry. 2013;13(21):2791-2806.
doi:10.2174/15680266113136660198 .
Popović, Visnja, Zivković, Jelena, Davidović, Slobodan, Stevanović, Milena, Stojković, Dejan, "Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action" in Current Topics in Medicinal Chemistry, 13, no. 21 (2013):2791-2806,
https://doi.org/10.2174/15680266113136660198 . .
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