TY  - JOUR
AU  - Pakos-Zebrucka, Karolina
AU  - Koryga, Izabela
AU  - Mnich, Katarzyna
AU  - Ljujić, Mila
AU  - Samali, Afshin
AU  - Gorman, Adrienne M.
PY  - 2016
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/927
AB  - In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) by one of four members of the eIF2 alpha kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. The gene expression program activated by the ISR optimizes the cellular response to stress and is dependent on the cellular context, as well as on the nature and intensity of the stress stimuli. Although the ISR is primarily a pro-survival, homeostatic program, exposure to severe stress can drive signaling toward cell death. Here, we review current understanding of the ISR signaling and how it regulates cell fate under diverse types of stress.
PB  - Wiley, Hoboken
T2  - EMBO Reports
T1  - The integrated stress response
EP  - 1395
IS  - 10
SP  - 1374
VL  - 17
DO  - 10.15252/embr.201642195
ER  - 

@article{
author = "Pakos-Zebrucka, Karolina and Koryga, Izabela and Mnich, Katarzyna and Ljujić, Mila and Samali, Afshin and Gorman, Adrienne M.",
year = "2016",
abstract = "In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) by one of four members of the eIF2 alpha kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. The gene expression program activated by the ISR optimizes the cellular response to stress and is dependent on the cellular context, as well as on the nature and intensity of the stress stimuli. Although the ISR is primarily a pro-survival, homeostatic program, exposure to severe stress can drive signaling toward cell death. Here, we review current understanding of the ISR signaling and how it regulates cell fate under diverse types of stress.",
publisher = "Wiley, Hoboken",
journal = "EMBO Reports",
title = "The integrated stress response",
pages = "1395-1374",
number = "10",
volume = "17",
doi = "10.15252/embr.201642195"
}

Pakos-Zebrucka, K., Koryga, I., Mnich, K., Ljujić, M., Samali, A.,& Gorman, A. M.. (2016). The integrated stress response. in EMBO Reports
Wiley, Hoboken., 17(10), 1374-1395.
https://doi.org/10.15252/embr.201642195

Pakos-Zebrucka K, Koryga I, Mnich K, Ljujić M, Samali A, Gorman AM. The integrated stress response. in EMBO Reports. 2016;17(10):1374-1395.
doi:10.15252/embr.201642195 .

Pakos-Zebrucka, Karolina, Koryga, Izabela, Mnich, Katarzyna, Ljujić, Mila, Samali, Afshin, Gorman, Adrienne M., "The integrated stress response" in EMBO Reports, 17, no. 10 (2016):1374-1395,
https://doi.org/10.15252/embr.201642195 . .