TY  - CONF
AU  - Stevanović, Nevena
AU  - Aleksic, Ivana
AU  - Kljun, Jakob
AU  - Ašanin, Darko
AU  - Andrejević, Tina
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
AU  - Djuran, Miloš
AU  - Glišić, Biljana
PY  - 2020
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1641
AB  - Over the last few decades, invasive fungal infections represent a serious problem for modern-day healthcare. Aspergillus, Candida and Cryptococcus species are the most common pathogens causing life-threatening infections. Therapeutic options for the treatment of fungal infections are presently limited to only four classes of compounds and each of these drug classes has significant therapeutic limitations, including serious toxic-side effects, resistance development and limited routes of administration. In order to overcome resistance of the clinically used antifungal triazole agents, we synthesized zinc(II) and copper(II) complexes with fluconazole (flz), {[ZnCl2(flz)2]·2C2H5OH}n (1) and {[CuCl2(flz)2].5H2O}n (2). These complexes were obtained from the reactions between ZnCl2 or CuCl2·2H2O with this antifungal agent in 1 : 2 molar ratio in ethanol at room temperature. The compounds were characterized by elemental analysis, NMR, IR and UV-Vis spectroscopy and mass spectrometry. The crystal structure of complex 1 was determined by a single-crystal X-ray diffraction analysis. The antimicrobial effect of both complexes and fluconazole was evaluated against different Candida species as well as Gram-positive and Gram-negative bacteria by means of minimal inhibitory concentrations (MICs). The obtained results have shown that, in most cases, the coordination of fluconazole to Zn(II) and Cu(II) ions leads to the enhancement of its antifungal activity. Both complexes showed strong inhibitory activity against C. albicans biofilm formation at concentrations lower than MIC values, as well as strong inhibition of C. albicans filamentation.
C3  - Electronic Conference on Medicinal Chemistry
T1  - Improvement of antifungal activity and therapeutic profile of fluconazole by its complexation with copper(II) and zinc(II) ions. Complex characterization and antimicrobial activity studies
DO  - 10.3390/ECMC2020-07373
ER  - 

@conference{
author = "Stevanović, Nevena and Aleksic, Ivana and Kljun, Jakob and Ašanin, Darko and Andrejević, Tina and Nikodinović-Runić, Jasmina and Turel, Iztok and Djuran, Miloš and Glišić, Biljana",
year = "2020",
abstract = "Over the last few decades, invasive fungal infections represent a serious problem for modern-day healthcare. Aspergillus, Candida and Cryptococcus species are the most common pathogens causing life-threatening infections. Therapeutic options for the treatment of fungal infections are presently limited to only four classes of compounds and each of these drug classes has significant therapeutic limitations, including serious toxic-side effects, resistance development and limited routes of administration. In order to overcome resistance of the clinically used antifungal triazole agents, we synthesized zinc(II) and copper(II) complexes with fluconazole (flz), {[ZnCl2(flz)2]·2C2H5OH}n (1) and {[CuCl2(flz)2].5H2O}n (2). These complexes were obtained from the reactions between ZnCl2 or CuCl2·2H2O with this antifungal agent in 1 : 2 molar ratio in ethanol at room temperature. The compounds were characterized by elemental analysis, NMR, IR and UV-Vis spectroscopy and mass spectrometry. The crystal structure of complex 1 was determined by a single-crystal X-ray diffraction analysis. The antimicrobial effect of both complexes and fluconazole was evaluated against different Candida species as well as Gram-positive and Gram-negative bacteria by means of minimal inhibitory concentrations (MICs). The obtained results have shown that, in most cases, the coordination of fluconazole to Zn(II) and Cu(II) ions leads to the enhancement of its antifungal activity. Both complexes showed strong inhibitory activity against C. albicans biofilm formation at concentrations lower than MIC values, as well as strong inhibition of C. albicans filamentation.",
journal = "Electronic Conference on Medicinal Chemistry",
title = "Improvement of antifungal activity and therapeutic profile of fluconazole by its complexation with copper(II) and zinc(II) ions. Complex characterization and antimicrobial activity studies",
doi = "10.3390/ECMC2020-07373"
}

Stevanović, N., Aleksic, I., Kljun, J., Ašanin, D., Andrejević, T., Nikodinović-Runić, J., Turel, I., Djuran, M.,& Glišić, B.. (2020). Improvement of antifungal activity and therapeutic profile of fluconazole by its complexation with copper(II) and zinc(II) ions. Complex characterization and antimicrobial activity studies. in Electronic Conference on Medicinal Chemistry.
https://doi.org/10.3390/ECMC2020-07373

Stevanović N, Aleksic I, Kljun J, Ašanin D, Andrejević T, Nikodinović-Runić J, Turel I, Djuran M, Glišić B. Improvement of antifungal activity and therapeutic profile of fluconazole by its complexation with copper(II) and zinc(II) ions. Complex characterization and antimicrobial activity studies. in Electronic Conference on Medicinal Chemistry. 2020;.
doi:10.3390/ECMC2020-07373 .

Stevanović, Nevena, Aleksic, Ivana, Kljun, Jakob, Ašanin, Darko, Andrejević, Tina, Nikodinović-Runić, Jasmina, Turel, Iztok, Djuran, Miloš, Glišić, Biljana, "Improvement of antifungal activity and therapeutic profile of fluconazole by its complexation with copper(II) and zinc(II) ions. Complex characterization and antimicrobial activity studies" in Electronic Conference on Medicinal Chemistry (2020),
https://doi.org/10.3390/ECMC2020-07373 . .

TY  - CONF
AU  - Asanin, Darko
AU  - Andrejević, Tina
AU  - Škaro Bogojević, Sanja
AU  - Perdih, Franc
AU  - Turel, Iztok
AU  - Nikodinović-Runić, Jasmina
AU  - Djuran, Miloš
AU  - Glišić, Biljana
PY  - 2020
UR  - https://imagine.imgge.bg.ac.rs/handle/123456789/1634
AB  - Silver(I) compounds are well known for their pharmacological applications as antibiotics and have been also evaluated as potential anticancer agents. The use of simple silver(I) salts, such as AgNO3, as an antimicrobial agent, has been limited due to the formation of AgCl precipitate under the physiological conditions, preventing a major part of Ag(I) ions to reach the infected site. On the other hand, a slow and maintainable release of Ag(I) ion into the infected cell or tissue could be achieved by its administration in the form of complexes. Among different classes of ligands used for the synthesis of biologically active silver(I) complexes, a special attention was devoted to the aromatic nitrogen-containing heterocycles. Considering this, in the present study, we have synthesized two new silver(I) complexes with 1,8-naphthyridine (1,8-naph), polynuclear [Ag(CF3SO3)(1,8-naph)]n (Ag1) and dinuclear [Ag(1,8-naph)(H2O)]2(PF6)2 (Ag2), and evaluated their antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as Candida spp. The obtained results revealed that these silver(I) complexes showed significant activity toward the Gram-positive Staphylococcus aureus and Candida spp. The values of binding constants of Ag1 and Ag2 to BSA are high enough to indicate their interaction to this biomolecule, but not so strong to prevent their release upon arrival to the target site. The partition coefficient (logP) values for Ag1 and Ag2 are -0.14 and 0.37, respectively, what is in accordance with those for pharmacophores in the Comprehensive Medicinal Chemistry database. Тhe investigated silver(I) complexes inside the cell could interact with DNA through the non-intercalative (electrostatic) mode.
C3  - Electronic Conference on Medicinal Chemistry
T1  - Antimicrobial activity and DNA/BSA binding study of new silver(I) complexes with 1,8-naphthyridine
DO  - 10.3390/ECMC2020-07372
ER  - 

@conference{
author = "Asanin, Darko and Andrejević, Tina and Škaro Bogojević, Sanja and Perdih, Franc and Turel, Iztok and Nikodinović-Runić, Jasmina and Djuran, Miloš and Glišić, Biljana",
year = "2020",
abstract = "Silver(I) compounds are well known for their pharmacological applications as antibiotics and have been also evaluated as potential anticancer agents. The use of simple silver(I) salts, such as AgNO3, as an antimicrobial agent, has been limited due to the formation of AgCl precipitate under the physiological conditions, preventing a major part of Ag(I) ions to reach the infected site. On the other hand, a slow and maintainable release of Ag(I) ion into the infected cell or tissue could be achieved by its administration in the form of complexes. Among different classes of ligands used for the synthesis of biologically active silver(I) complexes, a special attention was devoted to the aromatic nitrogen-containing heterocycles. Considering this, in the present study, we have synthesized two new silver(I) complexes with 1,8-naphthyridine (1,8-naph), polynuclear [Ag(CF3SO3)(1,8-naph)]n (Ag1) and dinuclear [Ag(1,8-naph)(H2O)]2(PF6)2 (Ag2), and evaluated their antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as Candida spp. The obtained results revealed that these silver(I) complexes showed significant activity toward the Gram-positive Staphylococcus aureus and Candida spp. The values of binding constants of Ag1 and Ag2 to BSA are high enough to indicate their interaction to this biomolecule, but not so strong to prevent their release upon arrival to the target site. The partition coefficient (logP) values for Ag1 and Ag2 are -0.14 and 0.37, respectively, what is in accordance with those for pharmacophores in the Comprehensive Medicinal Chemistry database. Тhe investigated silver(I) complexes inside the cell could interact with DNA through the non-intercalative (electrostatic) mode.",
journal = "Electronic Conference on Medicinal Chemistry",
title = "Antimicrobial activity and DNA/BSA binding study of new silver(I) complexes with 1,8-naphthyridine",
doi = "10.3390/ECMC2020-07372"
}

Asanin, D., Andrejević, T., Škaro Bogojević, S., Perdih, F., Turel, I., Nikodinović-Runić, J., Djuran, M.,& Glišić, B.. (2020). Antimicrobial activity and DNA/BSA binding study of new silver(I) complexes with 1,8-naphthyridine. in Electronic Conference on Medicinal Chemistry.
https://doi.org/10.3390/ECMC2020-07372

Asanin D, Andrejević T, Škaro Bogojević S, Perdih F, Turel I, Nikodinović-Runić J, Djuran M, Glišić B. Antimicrobial activity and DNA/BSA binding study of new silver(I) complexes with 1,8-naphthyridine. in Electronic Conference on Medicinal Chemistry. 2020;.
doi:10.3390/ECMC2020-07372 .

Asanin, Darko, Andrejević, Tina, Škaro Bogojević, Sanja, Perdih, Franc, Turel, Iztok, Nikodinović-Runić, Jasmina, Djuran, Miloš, Glišić, Biljana, "Antimicrobial activity and DNA/BSA binding study of new silver(I) complexes with 1,8-naphthyridine" in Electronic Conference on Medicinal Chemistry (2020),
https://doi.org/10.3390/ECMC2020-07372 . .