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Outcome of a Serbian pilot initiative: Spinal muscular atrophy newborn screening over a 16-month period
(International Journal of Medical Genetic, 2023)
Background: Spinal muscular atrophy
(SMA) is the prevalent genetic cause of childhood
mortality. Pioneering treatments yield utmost advantages
only within the presymptomatic phase,
underlining the significance of newborn ...
Investigation of the role of the glucose-6-phosphate translocase in the activation of autophagy and glycogen-selective autophagy in glycogen storage disease type IB patients
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Glycogen storage disease type Ib (GSD-Ib) is characterized by a deficiency of glucose-6-
phosphate translocase (G6PT) encoded by the SLC37A4 gene, affecting glucose homeostasis and disrupting autophagy. ...
Violacein enhances the cytotoxic effect of commonly used chemotherapeutics on rhabdomyosarcoma cells
(Belgrade : Serbian Association on for Cancer Research, 2023)
Investigati on of natural compounds showing specific toxicity to tumor cells aims to improve the efficacy
of available therapies. Our previous research demonstrated the cytotoxic acti vity of the bacterial pigment ...
The story of the SOX genes: for better or for worse…
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
The SOX genes encode a group of transcription factors showing diverse expression patterns during de- velopment and acting as key regulators of diverse cellular processes. SOX transcription factors are in- volved in multiple ...
Application of Next-Generation Sequencing Technology and Establishment of Biobanks
(Karger, Basel, 2018)
Institute of Molecular Genetics and Genetic Engineering has
become widely recognized as an expert centre for rare diseases
(RD). It is the first institution is Serbia that applied NGS methodology in research and diagnostics ...
Precision medicine and COVID-19: Importance of host genome profiling
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: The clinical picture and the course of the disease in COVID-19 patients, caused by coronavirus SARS-CoV-2, vary from asymptomatic to fatal outcome. As the same agent cause the disease, the
individual genomic ...
THE IMPACT OF NEXT-GENERATION SEQUENCING ON DIAGNOSIS AND TREATMENT OF RARE DISEASES
(Macedonian Academy of Sciences and Arts, 2023)
Introduction: Rare diseases are heterogeneous group of diseases, with one common characteristics, a
prevalence less than 1 in 2000 people. Vast majority of them are monogenic and finding pathogenic genetic
variants is ...
Prothrombin influences proliferation and migration of colon cancer in vitro
(Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 2023)
Introduction: Thrombin, crucial member of the coagulation cascade, can influence growth and development of different types of cancer. Prothrombin, thrombin precursor, although predominantly secreted
from the liver into ...
Food waste as a nutrient source for the production of biopigment in Streptomyces sp. BV365
(Beograd : Srpsko hemijsko društvo, 2023)
The genus Streptomyces has been studied for the vast secondary metabolite
production, biological activity of crude extracts, as well as colouring properties on textile
materials [1, 2]. Streptomyces sp. BV365 is a potent ...
High herbicide concentration tolerant bacteria in plant growth promotion
(CEESME Central and Eastern Europe Symposium on Microbial Ecology, 2023)
organisms, including microorganisms. In the global effort to increase agriculture sustainability, there
is an emerging need for herbicide-resilient plant growth-promoting (PGP) bacteria that improve
essential crops yield. ...