Copper(II) complexes with different diamines as inhibitors of bacterial quorum sensing activity
Authors
Stanojević, Ivana M.Aleksić, Ivana
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Drasković, Nenad S.
Glišić, Biljana
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Vojnović, Sandra
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Nikodinović-Runić, Jasmina
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Article (Published version)
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Three copper(II) complexes, trans-[Cu(1,3-pd)(2)Cl-2]center dot H2O (Cu1; 1,3-pd is 1,3-propanediamine), trans-[Cu(2,2-diMe-1,3-pd)(2)Cl-2] (Cu2; 2,2-diMe-1,3-pd is 2,2-dimethyl-1,3-propanediamine) and trans-[Cu(1,3-pnd)(2)Cl-2]center dot H2O (Cu3; 1,3-pnd is (+/-)-1,3-pentanediamine), were synthesized and structurally characterized by elemental microanalyses, IR, electronic absorption and reflectance spectroscopy and molar conductivity measurements. The antimicrobial efficiency of the complexes against four clinically relevant microorganisms and their antiproliferative effect on the normal human lung fibroblast cell line MRC-5 were evaluated. Since in many bacteria, pathogenicity is regulated by an intercellular communication process called quorum sensing (QS), the effect of the copper(II) complexes Cu1-3 on bacterial QS was examined. The obtained results showed that these complexes inhibited violacein production in Chromobacterium violaceum CV026, indicating their anti-QS activity vi...a the homoserine lactone (HSL) pathway. Two biosensor strains were used to determine which pathway, C4-HSL (N-butanoylhomoserine lactone) or 3OC12-HSL (N-(3-oxododecanoyl) homoserine lactone), was affected by the copper(II) complexes. The biological activities of the copper(II) complexes were compared with those for the nickel(II) complexes of the general formula trans-[Ni(L)(2)(H2O)(2)]Cl-2 (L = 1,3-pd, 2,2-diMe-1,3-pd and 1,3-pnd).
Keywords:
nitrogen-donor ligands / metal complexes / interbacterial communication / cytotoxicity / antimicrobial activitySource:
Journal of the Serbian Chemical Society, 2017, 82, 12, 1357-1367Publisher:
- Srpsko hemijsko društvo, Beograd
Funding / projects:
- SupraMedChem"Balkans.Net SCOPES Institutional Partnership [IZ74Z0_160515]
- Synthesis of new metal complexes and investigation of their reactions with peptides (RS-MESTD-Basic Research (BR or ON)-172036)
- Microbial diversity study and characterization of beneficial environmental microorganisms (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.2298/JSC170706087S
ISSN: 0352-5139
WoS: 000419391700003
Scopus: 2-s2.0-85040027639
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Stanojević, Ivana M. AU - Aleksić, Ivana AU - Drasković, Nenad S. AU - Glišić, Biljana AU - Vojnović, Sandra AU - Nikodinović-Runić, Jasmina PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1021 AB - Three copper(II) complexes, trans-[Cu(1,3-pd)(2)Cl-2]center dot H2O (Cu1; 1,3-pd is 1,3-propanediamine), trans-[Cu(2,2-diMe-1,3-pd)(2)Cl-2] (Cu2; 2,2-diMe-1,3-pd is 2,2-dimethyl-1,3-propanediamine) and trans-[Cu(1,3-pnd)(2)Cl-2]center dot H2O (Cu3; 1,3-pnd is (+/-)-1,3-pentanediamine), were synthesized and structurally characterized by elemental microanalyses, IR, electronic absorption and reflectance spectroscopy and molar conductivity measurements. The antimicrobial efficiency of the complexes against four clinically relevant microorganisms and their antiproliferative effect on the normal human lung fibroblast cell line MRC-5 were evaluated. Since in many bacteria, pathogenicity is regulated by an intercellular communication process called quorum sensing (QS), the effect of the copper(II) complexes Cu1-3 on bacterial QS was examined. The obtained results showed that these complexes inhibited violacein production in Chromobacterium violaceum CV026, indicating their anti-QS activity via the homoserine lactone (HSL) pathway. Two biosensor strains were used to determine which pathway, C4-HSL (N-butanoylhomoserine lactone) or 3OC12-HSL (N-(3-oxododecanoyl) homoserine lactone), was affected by the copper(II) complexes. The biological activities of the copper(II) complexes were compared with those for the nickel(II) complexes of the general formula trans-[Ni(L)(2)(H2O)(2)]Cl-2 (L = 1,3-pd, 2,2-diMe-1,3-pd and 1,3-pnd). PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Copper(II) complexes with different diamines as inhibitors of bacterial quorum sensing activity EP - 1367 IS - 12 SP - 1357 VL - 82 DO - 10.2298/JSC170706087S ER -
@article{ author = "Stanojević, Ivana M. and Aleksić, Ivana and Drasković, Nenad S. and Glišić, Biljana and Vojnović, Sandra and Nikodinović-Runić, Jasmina", year = "2017", abstract = "Three copper(II) complexes, trans-[Cu(1,3-pd)(2)Cl-2]center dot H2O (Cu1; 1,3-pd is 1,3-propanediamine), trans-[Cu(2,2-diMe-1,3-pd)(2)Cl-2] (Cu2; 2,2-diMe-1,3-pd is 2,2-dimethyl-1,3-propanediamine) and trans-[Cu(1,3-pnd)(2)Cl-2]center dot H2O (Cu3; 1,3-pnd is (+/-)-1,3-pentanediamine), were synthesized and structurally characterized by elemental microanalyses, IR, electronic absorption and reflectance spectroscopy and molar conductivity measurements. The antimicrobial efficiency of the complexes against four clinically relevant microorganisms and their antiproliferative effect on the normal human lung fibroblast cell line MRC-5 were evaluated. Since in many bacteria, pathogenicity is regulated by an intercellular communication process called quorum sensing (QS), the effect of the copper(II) complexes Cu1-3 on bacterial QS was examined. The obtained results showed that these complexes inhibited violacein production in Chromobacterium violaceum CV026, indicating their anti-QS activity via the homoserine lactone (HSL) pathway. Two biosensor strains were used to determine which pathway, C4-HSL (N-butanoylhomoserine lactone) or 3OC12-HSL (N-(3-oxododecanoyl) homoserine lactone), was affected by the copper(II) complexes. The biological activities of the copper(II) complexes were compared with those for the nickel(II) complexes of the general formula trans-[Ni(L)(2)(H2O)(2)]Cl-2 (L = 1,3-pd, 2,2-diMe-1,3-pd and 1,3-pnd).", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Copper(II) complexes with different diamines as inhibitors of bacterial quorum sensing activity", pages = "1367-1357", number = "12", volume = "82", doi = "10.2298/JSC170706087S" }
Stanojević, I. M., Aleksić, I., Drasković, N. S., Glišić, B., Vojnović, S.,& Nikodinović-Runić, J.. (2017). Copper(II) complexes with different diamines as inhibitors of bacterial quorum sensing activity. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 82(12), 1357-1367. https://doi.org/10.2298/JSC170706087S
Stanojević IM, Aleksić I, Drasković NS, Glišić B, Vojnović S, Nikodinović-Runić J. Copper(II) complexes with different diamines as inhibitors of bacterial quorum sensing activity. in Journal of the Serbian Chemical Society. 2017;82(12):1357-1367. doi:10.2298/JSC170706087S .
Stanojević, Ivana M., Aleksić, Ivana, Drasković, Nenad S., Glišić, Biljana, Vojnović, Sandra, Nikodinović-Runić, Jasmina, "Copper(II) complexes with different diamines as inhibitors of bacterial quorum sensing activity" in Journal of the Serbian Chemical Society, 82, no. 12 (2017):1357-1367, https://doi.org/10.2298/JSC170706087S . .