Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis
Апстракт
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder affecting upper and lower motoneurons. The two types, sporadic and familial differ in the aetiopathogenesis but have a similar neuropathology characterized by oxidative stress, excitotoxicity and inflammation. The disease is also characterized by a non-cell autonomous mechanism with astrocytes playing a central role by affecting synaptic glutamate, the blood-brain barrier, and metabolic and trophic support. Two types of therapeutic approaches focusing on astrocytes are presented: a) emerging molecular targets (potassium inward rectifier channels and aquaporins at the astrocyte end-feet, and IP3 receptor signaling pathway), and b) cell therapy with stem cell - generated and transplanted astrocytes.
Кључне речи:
stem cells / Kir4.1 / IP3 receptor pathway / endfeet / cell transplantation / Blood-brain barrier / astrocyte / AQP4Извор:
Current Pharmaceutical Design, 2017, 23, 33, 5037-5044Издавач:
- Bentham Science Publ Ltd, Sharjah
Финансирање / пројекти:
- Биомаркери у неуродегенеративним и малигним процесима (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41005)
- grant YoungBrain (EU ESF)
- Croatian Science Foundation [IP-2016-06-9451]
- billateral Croatian-Serbian grant [2016/17]
DOI: 10.2174/1381612823666170615110446
ISSN: 1381-6128
PubMed: 28619002
WoS: 000419735900011
Scopus: 2-s2.0-85027852958
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Perić, Mina AU - Mitrecić, Dinko AU - Andjus, Pavle R. PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1023 AB - Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder affecting upper and lower motoneurons. The two types, sporadic and familial differ in the aetiopathogenesis but have a similar neuropathology characterized by oxidative stress, excitotoxicity and inflammation. The disease is also characterized by a non-cell autonomous mechanism with astrocytes playing a central role by affecting synaptic glutamate, the blood-brain barrier, and metabolic and trophic support. Two types of therapeutic approaches focusing on astrocytes are presented: a) emerging molecular targets (potassium inward rectifier channels and aquaporins at the astrocyte end-feet, and IP3 receptor signaling pathway), and b) cell therapy with stem cell - generated and transplanted astrocytes. PB - Bentham Science Publ Ltd, Sharjah T2 - Current Pharmaceutical Design T1 - Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis EP - 5044 IS - 33 SP - 5037 VL - 23 DO - 10.2174/1381612823666170615110446 ER -
@article{ author = "Perić, Mina and Mitrecić, Dinko and Andjus, Pavle R.", year = "2017", abstract = "Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder affecting upper and lower motoneurons. The two types, sporadic and familial differ in the aetiopathogenesis but have a similar neuropathology characterized by oxidative stress, excitotoxicity and inflammation. The disease is also characterized by a non-cell autonomous mechanism with astrocytes playing a central role by affecting synaptic glutamate, the blood-brain barrier, and metabolic and trophic support. Two types of therapeutic approaches focusing on astrocytes are presented: a) emerging molecular targets (potassium inward rectifier channels and aquaporins at the astrocyte end-feet, and IP3 receptor signaling pathway), and b) cell therapy with stem cell - generated and transplanted astrocytes.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Current Pharmaceutical Design", title = "Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis", pages = "5044-5037", number = "33", volume = "23", doi = "10.2174/1381612823666170615110446" }
Perić, M., Mitrecić, D.,& Andjus, P. R.. (2017). Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis. in Current Pharmaceutical Design Bentham Science Publ Ltd, Sharjah., 23(33), 5037-5044. https://doi.org/10.2174/1381612823666170615110446
Perić M, Mitrecić D, Andjus PR. Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis. in Current Pharmaceutical Design. 2017;23(33):5037-5044. doi:10.2174/1381612823666170615110446 .
Perić, Mina, Mitrecić, Dinko, Andjus, Pavle R., "Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis" in Current Pharmaceutical Design, 23, no. 33 (2017):5037-5044, https://doi.org/10.2174/1381612823666170615110446 . .