Are Prothrombotic Mutations a Time-to-Event Risk Factor?
2017
Authors
Tomić, BrankoGvozdenov, Maja
Pruner, Iva
Simić, Jelena M.
Kovač, Mirjana
Radojković, Dragica
Đorđević, Valentina
Article (Published version)
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Background: Deep vein thrombosis (DVT) represents a common disorder involving genetic and acquired risk factors. It has been proposed that acquired risk factors are more important with aging than genetic factors, indicating different prevalence of prothrombotic mutations throughout the lifespan. Objective: To determine the role of the most frequent prothrombotic genetic risk factors (Factor V [FV] Leiden and Factor II [FII] G20210A mutations) in first-time DVT etiology in patients of different ages. Method: This retrospective study included 701 patients living in Serbia with diagnosed DVT as a first-time thrombotic event. Results: Risk assessment for mutations as age-related markers showed no statistical difference (FV Leiden mutation-OR, 1.027; 95% confidence interval [CI],.87-1.22; P=.76 and FII G20210A mutation-OR, 0.940, 95% CI,.74-1.19; P=.61). Our results show similar mutation prevalence regardless of how old the patients were at the time of the first DVT occurrence. Conclusion: ...Our results indicate that these 2 mutations cannot be used as prognostic marker for time-to-event first DVT in the Serbian population; however, further studies are required.
Keywords:
thrombophilia / prognostic marker / FV Leiden / FII G20210A / deep venous thrombosis / agingSource:
Laboratory Medicine, 2017, 48, 4, 326-331Publisher:
- Oxford Univ Press, Oxford
Funding / projects:
- Complex diseases as a model system for phenotype modulation- structural and functional analysis of molecular biomarkers (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.1093/labmed/lmx046
ISSN: 0007-5027
PubMed: 29036518
WoS: 000424018900007
Scopus: 2-s2.0-85044136244
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Tomić, Branko AU - Gvozdenov, Maja AU - Pruner, Iva AU - Simić, Jelena M. AU - Kovač, Mirjana AU - Radojković, Dragica AU - Đorđević, Valentina PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1025 AB - Background: Deep vein thrombosis (DVT) represents a common disorder involving genetic and acquired risk factors. It has been proposed that acquired risk factors are more important with aging than genetic factors, indicating different prevalence of prothrombotic mutations throughout the lifespan. Objective: To determine the role of the most frequent prothrombotic genetic risk factors (Factor V [FV] Leiden and Factor II [FII] G20210A mutations) in first-time DVT etiology in patients of different ages. Method: This retrospective study included 701 patients living in Serbia with diagnosed DVT as a first-time thrombotic event. Results: Risk assessment for mutations as age-related markers showed no statistical difference (FV Leiden mutation-OR, 1.027; 95% confidence interval [CI],.87-1.22; P=.76 and FII G20210A mutation-OR, 0.940, 95% CI,.74-1.19; P=.61). Our results show similar mutation prevalence regardless of how old the patients were at the time of the first DVT occurrence. Conclusion: Our results indicate that these 2 mutations cannot be used as prognostic marker for time-to-event first DVT in the Serbian population; however, further studies are required. PB - Oxford Univ Press, Oxford T2 - Laboratory Medicine T1 - Are Prothrombotic Mutations a Time-to-Event Risk Factor? EP - 331 IS - 4 SP - 326 VL - 48 DO - 10.1093/labmed/lmx046 ER -
@article{ author = "Tomić, Branko and Gvozdenov, Maja and Pruner, Iva and Simić, Jelena M. and Kovač, Mirjana and Radojković, Dragica and Đorđević, Valentina", year = "2017", abstract = "Background: Deep vein thrombosis (DVT) represents a common disorder involving genetic and acquired risk factors. It has been proposed that acquired risk factors are more important with aging than genetic factors, indicating different prevalence of prothrombotic mutations throughout the lifespan. Objective: To determine the role of the most frequent prothrombotic genetic risk factors (Factor V [FV] Leiden and Factor II [FII] G20210A mutations) in first-time DVT etiology in patients of different ages. Method: This retrospective study included 701 patients living in Serbia with diagnosed DVT as a first-time thrombotic event. Results: Risk assessment for mutations as age-related markers showed no statistical difference (FV Leiden mutation-OR, 1.027; 95% confidence interval [CI],.87-1.22; P=.76 and FII G20210A mutation-OR, 0.940, 95% CI,.74-1.19; P=.61). Our results show similar mutation prevalence regardless of how old the patients were at the time of the first DVT occurrence. Conclusion: Our results indicate that these 2 mutations cannot be used as prognostic marker for time-to-event first DVT in the Serbian population; however, further studies are required.", publisher = "Oxford Univ Press, Oxford", journal = "Laboratory Medicine", title = "Are Prothrombotic Mutations a Time-to-Event Risk Factor?", pages = "331-326", number = "4", volume = "48", doi = "10.1093/labmed/lmx046" }
Tomić, B., Gvozdenov, M., Pruner, I., Simić, J. M., Kovač, M., Radojković, D.,& Đorđević, V.. (2017). Are Prothrombotic Mutations a Time-to-Event Risk Factor?. in Laboratory Medicine Oxford Univ Press, Oxford., 48(4), 326-331. https://doi.org/10.1093/labmed/lmx046
Tomić B, Gvozdenov M, Pruner I, Simić JM, Kovač M, Radojković D, Đorđević V. Are Prothrombotic Mutations a Time-to-Event Risk Factor?. in Laboratory Medicine. 2017;48(4):326-331. doi:10.1093/labmed/lmx046 .
Tomić, Branko, Gvozdenov, Maja, Pruner, Iva, Simić, Jelena M., Kovač, Mirjana, Radojković, Dragica , Đorđević, Valentina, "Are Prothrombotic Mutations a Time-to-Event Risk Factor?" in Laboratory Medicine, 48, no. 4 (2017):326-331, https://doi.org/10.1093/labmed/lmx046 . .