The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome
Нема приказа
Аутори
Cuturilo, GoranDrakulić, Danijela
Jovanović, Ida
Ilić, Slobodan
Kalanj, Jasna
Vulicević, Irena
Raus, Misela
Skorić, Dejan
Mijović, Marija
Medjo, Biljana
Rsovac, Snežana
Stevanović, Milena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
22q11.2 microdeletion is the most common microdeletion in humans. The purpose of this study was to evaluate postoperative outcome in children with 22q11.2 microdeletion who had undergone complete surgical correction of a congenital heart defect. The study included 34 patients who underwent complete correction of conotruncal heart defects. Of these, 17 patients diagnosed with 22q11.2 microdeletion represent the investigated group. Another 17 patients without 22q11.2 microdeletion represent the control group. Investigated and control groups differ significantly for total length of stay in the hospital (average 37.35 and 14.12 days, respectively); length of postoperative stay in the intensive care unit (average 10.82 and 6.76 days, respectively); sepsis (eight and two patients, respectively); administration of antibiotics (15 and seven patients, respectively); duration of antibiotic therapy (average 17.65 and 14.59 days, respectively); occurrence of hypocalcemia (16 and 0 patients, respec...tively); and initiation of peroral nutrition during the postoperative course (average 10.29 and 3.88 days, respectively). No difference was found for duration of ventilatory support (average 6.12 and 4.24 days, respectively), administration of total parenteral nutrition, and postoperative mortality rate. The study results suggest that genotype of 22q11.2 microdeletion affects postoperative outcome after cardiac surgery. Possible targets for intervention in postoperative intensive care management are prevention and treatment of systemic infections, monitoring, and treatment of hypocalcemias, rational administration of antibiotics and careful planning of nutrition. Consequently, this could shorten patients' intensive care stay and overall duration of hospitalization.
Кључне речи:
Postoperative care / Pediatrics / Intensive care / Congenital heart defect / 22q11.2 deletion syndromeИзвор:
Pediatric Cardiology, 2017, 38, 8, 1680-1685Издавач:
- Springer, New York
Финансирање / пројекти:
- Проучавање сигналних путева и епигенетичких механизама укључених у контролу експресије хуманих SOX гена: даље расветљавање њихове улоге у одређивању судбине и диференцијацији ћелија (RS-MESTD-Basic Research (BR or ON)-173051)
DOI: 10.1007/s00246-017-1713-7
ISSN: 0172-0643
PubMed: 28940032
WoS: 000415580300021
Scopus: 2-s2.0-85029740131
Институција/група
Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Cuturilo, Goran AU - Drakulić, Danijela AU - Jovanović, Ida AU - Ilić, Slobodan AU - Kalanj, Jasna AU - Vulicević, Irena AU - Raus, Misela AU - Skorić, Dejan AU - Mijović, Marija AU - Medjo, Biljana AU - Rsovac, Snežana AU - Stevanović, Milena PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1035 AB - 22q11.2 microdeletion is the most common microdeletion in humans. The purpose of this study was to evaluate postoperative outcome in children with 22q11.2 microdeletion who had undergone complete surgical correction of a congenital heart defect. The study included 34 patients who underwent complete correction of conotruncal heart defects. Of these, 17 patients diagnosed with 22q11.2 microdeletion represent the investigated group. Another 17 patients without 22q11.2 microdeletion represent the control group. Investigated and control groups differ significantly for total length of stay in the hospital (average 37.35 and 14.12 days, respectively); length of postoperative stay in the intensive care unit (average 10.82 and 6.76 days, respectively); sepsis (eight and two patients, respectively); administration of antibiotics (15 and seven patients, respectively); duration of antibiotic therapy (average 17.65 and 14.59 days, respectively); occurrence of hypocalcemia (16 and 0 patients, respectively); and initiation of peroral nutrition during the postoperative course (average 10.29 and 3.88 days, respectively). No difference was found for duration of ventilatory support (average 6.12 and 4.24 days, respectively), administration of total parenteral nutrition, and postoperative mortality rate. The study results suggest that genotype of 22q11.2 microdeletion affects postoperative outcome after cardiac surgery. Possible targets for intervention in postoperative intensive care management are prevention and treatment of systemic infections, monitoring, and treatment of hypocalcemias, rational administration of antibiotics and careful planning of nutrition. Consequently, this could shorten patients' intensive care stay and overall duration of hospitalization. PB - Springer, New York T2 - Pediatric Cardiology T1 - The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome EP - 1685 IS - 8 SP - 1680 VL - 38 DO - 10.1007/s00246-017-1713-7 ER -
@article{ author = "Cuturilo, Goran and Drakulić, Danijela and Jovanović, Ida and Ilić, Slobodan and Kalanj, Jasna and Vulicević, Irena and Raus, Misela and Skorić, Dejan and Mijović, Marija and Medjo, Biljana and Rsovac, Snežana and Stevanović, Milena", year = "2017", abstract = "22q11.2 microdeletion is the most common microdeletion in humans. The purpose of this study was to evaluate postoperative outcome in children with 22q11.2 microdeletion who had undergone complete surgical correction of a congenital heart defect. The study included 34 patients who underwent complete correction of conotruncal heart defects. Of these, 17 patients diagnosed with 22q11.2 microdeletion represent the investigated group. Another 17 patients without 22q11.2 microdeletion represent the control group. Investigated and control groups differ significantly for total length of stay in the hospital (average 37.35 and 14.12 days, respectively); length of postoperative stay in the intensive care unit (average 10.82 and 6.76 days, respectively); sepsis (eight and two patients, respectively); administration of antibiotics (15 and seven patients, respectively); duration of antibiotic therapy (average 17.65 and 14.59 days, respectively); occurrence of hypocalcemia (16 and 0 patients, respectively); and initiation of peroral nutrition during the postoperative course (average 10.29 and 3.88 days, respectively). No difference was found for duration of ventilatory support (average 6.12 and 4.24 days, respectively), administration of total parenteral nutrition, and postoperative mortality rate. The study results suggest that genotype of 22q11.2 microdeletion affects postoperative outcome after cardiac surgery. Possible targets for intervention in postoperative intensive care management are prevention and treatment of systemic infections, monitoring, and treatment of hypocalcemias, rational administration of antibiotics and careful planning of nutrition. Consequently, this could shorten patients' intensive care stay and overall duration of hospitalization.", publisher = "Springer, New York", journal = "Pediatric Cardiology", title = "The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome", pages = "1685-1680", number = "8", volume = "38", doi = "10.1007/s00246-017-1713-7" }
Cuturilo, G., Drakulić, D., Jovanović, I., Ilić, S., Kalanj, J., Vulicević, I., Raus, M., Skorić, D., Mijović, M., Medjo, B., Rsovac, S.,& Stevanović, M.. (2017). The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome. in Pediatric Cardiology Springer, New York., 38(8), 1680-1685. https://doi.org/10.1007/s00246-017-1713-7
Cuturilo G, Drakulić D, Jovanović I, Ilić S, Kalanj J, Vulicević I, Raus M, Skorić D, Mijović M, Medjo B, Rsovac S, Stevanović M. The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome. in Pediatric Cardiology. 2017;38(8):1680-1685. doi:10.1007/s00246-017-1713-7 .
Cuturilo, Goran, Drakulić, Danijela, Jovanović, Ida, Ilić, Slobodan, Kalanj, Jasna, Vulicević, Irena, Raus, Misela, Skorić, Dejan, Mijović, Marija, Medjo, Biljana, Rsovac, Snežana, Stevanović, Milena, "The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome" in Pediatric Cardiology, 38, no. 8 (2017):1680-1685, https://doi.org/10.1007/s00246-017-1713-7 . .