Probiotics or pro-healers: the role of beneficial bacteria in tissue repair
Authors
Lukić, JovankaChen, Vivien
Strahinić, Ivana
Begović, Jelena
Lev-Tov, Hadar
Davis, Stephen C.
Tomić-Canić, Marjana
Pastar, Irena
Article (Accepted Version)
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Show full item recordAbstract
Probiotics are beneficial microorganisms, known to exert numerous positive effects on human health, primarily in the battle against pathogens. Probiotics have been associated with improved healing of intestinal ulcers, and healing of infected cutaneous wounds. This article reviews the latest findings on probiotics related to their pro-healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts, and epithelial cells' migration and function. Beneficial immunomodulatory effects of probiotics relate to modulation and activation of intraepithelial lymphocytes, natural killer cells, and macrophages through induced production of cytokines. Systemic effects of beneficial bacteria and link between gut microbiota, immune system, and cutaneous health through gut-brain-skin axes are discus...sed as well. In light of growing antibiotic resistance of pathogens, antibiotic use is becoming less effective in treating cutaneous and systemic infections. This review points to a new perspective and therapeutic potential of beneficial probiotic species as a safe alternative approach for treatment of patients affected by wound healing disorders and cutaneous infections.
Source:
Wound Repair and Regeneration, 2017, 25, 6, 912-922Publisher:
- Wiley, Hoboken
Funding / projects:
- Brian V. Jegasothy Foundation, Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine, Ministry of Education, Science and Technological Development, Republic of Serbia
- National Institute of Health [1R01NR01564]
- Genes and molecular mechanisms promoting probiotic activity of lactic acid bacteria from Western Balkan (RS-MESTD-Basic Research (BR or ON)-173019)
- NATIONAL INSTITUTE OF NURSING RESEARCH [R01NR013881, R01NR015649] Funding Source: NIH RePORTER
Note:
- This is the peer reviewed version of the paper: Lukic, J., Chen, V., Strahinic, I., Begovic, J., Lev-Tov, H., Davis, S. C., Tomic-Canic, M., & Pastar, I. (2017). Probiotics or pro-healers: The role of beneficial bacteria in tissue repair. Wound Repair and Regeneration, 25(6), 912–922. https://doi.org/10.1111/wrr.12607
Related info:
- Version of
https://doi.org/10.1111/wrr.12607
DOI: 10.1111/wrr.12607
ISSN: 1067-1927
PubMed: 29315980
WoS: 000427602100001
Scopus: 2-s2.0-85041548045
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Institut za molekularnu genetiku i genetičko inženjerstvoTY - JOUR AU - Lukić, Jovanka AU - Chen, Vivien AU - Strahinić, Ivana AU - Begović, Jelena AU - Lev-Tov, Hadar AU - Davis, Stephen C. AU - Tomić-Canić, Marjana AU - Pastar, Irena PY - 2017 UR - https://imagine.imgge.bg.ac.rs/handle/123456789/1042 AB - Probiotics are beneficial microorganisms, known to exert numerous positive effects on human health, primarily in the battle against pathogens. Probiotics have been associated with improved healing of intestinal ulcers, and healing of infected cutaneous wounds. This article reviews the latest findings on probiotics related to their pro-healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts, and epithelial cells' migration and function. Beneficial immunomodulatory effects of probiotics relate to modulation and activation of intraepithelial lymphocytes, natural killer cells, and macrophages through induced production of cytokines. Systemic effects of beneficial bacteria and link between gut microbiota, immune system, and cutaneous health through gut-brain-skin axes are discussed as well. In light of growing antibiotic resistance of pathogens, antibiotic use is becoming less effective in treating cutaneous and systemic infections. This review points to a new perspective and therapeutic potential of beneficial probiotic species as a safe alternative approach for treatment of patients affected by wound healing disorders and cutaneous infections. PB - Wiley, Hoboken T2 - Wound Repair and Regeneration T1 - Probiotics or pro-healers: the role of beneficial bacteria in tissue repair EP - 922 IS - 6 SP - 912 VL - 25 DO - 10.1111/wrr.12607 ER -
@article{ author = "Lukić, Jovanka and Chen, Vivien and Strahinić, Ivana and Begović, Jelena and Lev-Tov, Hadar and Davis, Stephen C. and Tomić-Canić, Marjana and Pastar, Irena", year = "2017", abstract = "Probiotics are beneficial microorganisms, known to exert numerous positive effects on human health, primarily in the battle against pathogens. Probiotics have been associated with improved healing of intestinal ulcers, and healing of infected cutaneous wounds. This article reviews the latest findings on probiotics related to their pro-healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts, and epithelial cells' migration and function. Beneficial immunomodulatory effects of probiotics relate to modulation and activation of intraepithelial lymphocytes, natural killer cells, and macrophages through induced production of cytokines. Systemic effects of beneficial bacteria and link between gut microbiota, immune system, and cutaneous health through gut-brain-skin axes are discussed as well. In light of growing antibiotic resistance of pathogens, antibiotic use is becoming less effective in treating cutaneous and systemic infections. This review points to a new perspective and therapeutic potential of beneficial probiotic species as a safe alternative approach for treatment of patients affected by wound healing disorders and cutaneous infections.", publisher = "Wiley, Hoboken", journal = "Wound Repair and Regeneration", title = "Probiotics or pro-healers: the role of beneficial bacteria in tissue repair", pages = "922-912", number = "6", volume = "25", doi = "10.1111/wrr.12607" }
Lukić, J., Chen, V., Strahinić, I., Begović, J., Lev-Tov, H., Davis, S. C., Tomić-Canić, M.,& Pastar, I.. (2017). Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. in Wound Repair and Regeneration Wiley, Hoboken., 25(6), 912-922. https://doi.org/10.1111/wrr.12607
Lukić J, Chen V, Strahinić I, Begović J, Lev-Tov H, Davis SC, Tomić-Canić M, Pastar I. Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. in Wound Repair and Regeneration. 2017;25(6):912-922. doi:10.1111/wrr.12607 .
Lukić, Jovanka, Chen, Vivien, Strahinić, Ivana, Begović, Jelena, Lev-Tov, Hadar, Davis, Stephen C., Tomić-Canić, Marjana, Pastar, Irena, "Probiotics or pro-healers: the role of beneficial bacteria in tissue repair" in Wound Repair and Regeneration, 25, no. 6 (2017):912-922, https://doi.org/10.1111/wrr.12607 . .